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The map label for this gene is cbs [H]

Identifier: 83592126

GI number: 83592126

Start: 939595

End: 940959

Strand: Reverse

Name: cbs [H]

Synonym: Rru_A0787

Alternate gene names: 83592126

Gene position: 940959-939595 (Counterclockwise)

Preceding gene: 83592131

Following gene: 83592125

Centisome position: 21.62

GC content: 64.54

Gene sequence:

>1365_bases
ATGACAGCCCCCGTCGATCTCCTCGCCCAGATCGGTCACACGCCGATCGTCCGCCTCGATCACCTCGATACCGGGCCCTG
TTCGCTGTTTGTGAAGCTTGAAAGCCAGAACCCCTCGGGTTCGATCAAAGACCGCATCGCCGTGTCGATGATCGATGCCG
CCGAACGCGATGGCCGGTTGAAGCCCAAGGGCAGGATCGTCGAGGCGACGGCGGGCAACACCGGCCTTGCCCTGGCCCTG
GTGGCGGCGCGCCGCGGCTACCATTTGACCCTGGTCATCCCCGATAAGATGAGCCGGGAAAAGATCGCCCATGTGCGGGC
GATGGGGGCCGAGGTGGTGCTGACGCGCTCGGATATCGGCAAGGGCCATCCGGCCTATTACCAGGATCTGGCCCAGCGCA
TCGCCGACGAGACCGGGGCCTTCTTCACCGATCAGTTCAACAATCCCGACAATCCGATCGCCCATGAAACCGGCACCGGC
CCCGAGATCTGGGAGCAGATGGACGGCCGGGTCGACGCCGTGGTCGCCGGCGTCGGATCGGGCGGCACCCTGACCGGGTT
GTCGCGGTTTTTCGCCCGTGTCTCGCCGCAGACCGATATCGTTCTGGCCGATCCCAAGGGCTCGATCCTGGCCGATTACG
TGACATCGGGGCGGATCGGCGCGGCGGGATCCTGGCTGGTCGAAGGCATCGGCGAGGATTTCGTGCCGCCGGTCTCGGAT
CTGTCGCGGGTGACCCACGCCTATACCATTCCCGACGGCGAAAGCTTCGCCACGGCGCGCGGCGTGCTGCGCCAGGAAGG
GCTGCTGATCGGCTCGTCCTCGGGCACCTTGCTGGCCGCGGCCTTGCGCTATTGCCGCGAACAGACCAGCCCGAAGCGGG
TGGTCAGCTTCGTCTGCGACAGTGGCAATAAATACCTATCAAAGATGTATAATGATTTCTGGATGGCCGATCAGGGTCTG
TCCAACCGTCCGCGCTTTGGCGATCTGCGCGACTTGATCGCGCGGCGCCAGGACGAGGGCGCGGTGGTCTCCGTCGCCCC
CGGCGATACCCTGGCCATCGCCTATCAGCGCATGAAGCTTTACGACGTTTCCCAATTGCCCGTTCTCGACGGGACCCGCT
GCGTCGGGTTGATCGACGAATCGGACGTTTTGCTCAGCCTGCGCGAGCGCGGCGGGCTGTTCGACGTCGCCGTCAGCGCG
GCGATGTCGACCGATTTGGAAACCGTTGGTCCCGACGCCGACGCCGACCACCTTGTCGGGCTGTTCGATCGCGGACGCGT
CGCCATCGTTGTCGATGACAGCGGTTTCCTCGGGCTGATCACCCGCATCGATTTCCTGAACCATCTAAGGGGCAAAGCCG
CATGA

Upstream 100 bases:

>100_bases
CACCGTCCATCCCTCAAGGCGCGGATTTAAGACTATTGAGCCTTGACGGCCGCGGTCAAGGGGCATTACCTTTTAGTTGA
TAGATTTTATGGAGTTATAA

Downstream 100 bases:

>100_bases
GCGCGTCCATCATCACCACCACCAAGGGCTTCGCCACCTGGGCCGTCCACGCCGGCCATGGCGCCGATGCGACCACCGGC
GCGGTCATGACGCCGATCTA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTAPVDLLAQIGHTPIVRLDHLDTGPCSLFVKLESQNPSGSIKDRIAVSMIDAAERDGRLKPKGRIVEATAGNTGLALAL
VAARRGYHLTLVIPDKMSREKIAHVRAMGAEVVLTRSDIGKGHPAYYQDLAQRIADETGAFFTDQFNNPDNPIAHETGTG
PEIWEQMDGRVDAVVAGVGSGGTLTGLSRFFARVSPQTDIVLADPKGSILADYVTSGRIGAAGSWLVEGIGEDFVPPVSD
LSRVTHAYTIPDGESFATARGVLRQEGLLIGSSSGTLLAAALRYCREQTSPKRVVSFVCDSGNKYLSKMYNDFWMADQGL
SNRPRFGDLRDLIARRQDEGAVVSVAPGDTLAIAYQRMKLYDVSQLPVLDGTRCVGLIDESDVLLSLRERGGLFDVAVSA
AMSTDLETVGPDADADHLVGLFDRGRVAIVVDDSGFLGLITRIDFLNHLRGKAA

Sequences:

>Translated_454_residues
MTAPVDLLAQIGHTPIVRLDHLDTGPCSLFVKLESQNPSGSIKDRIAVSMIDAAERDGRLKPKGRIVEATAGNTGLALAL
VAARRGYHLTLVIPDKMSREKIAHVRAMGAEVVLTRSDIGKGHPAYYQDLAQRIADETGAFFTDQFNNPDNPIAHETGTG
PEIWEQMDGRVDAVVAGVGSGGTLTGLSRFFARVSPQTDIVLADPKGSILADYVTSGRIGAAGSWLVEGIGEDFVPPVSD
LSRVTHAYTIPDGESFATARGVLRQEGLLIGSSSGTLLAAALRYCREQTSPKRVVSFVCDSGNKYLSKMYNDFWMADQGL
SNRPRFGDLRDLIARRQDEGAVVSVAPGDTLAIAYQRMKLYDVSQLPVLDGTRCVGLIDESDVLLSLRERGGLFDVAVSA
AMSTDLETVGPDADADHLVGLFDRGRVAIVVDDSGFLGLITRIDFLNHLRGKAA
>Mature_453_residues
TAPVDLLAQIGHTPIVRLDHLDTGPCSLFVKLESQNPSGSIKDRIAVSMIDAAERDGRLKPKGRIVEATAGNTGLALALV
AARRGYHLTLVIPDKMSREKIAHVRAMGAEVVLTRSDIGKGHPAYYQDLAQRIADETGAFFTDQFNNPDNPIAHETGTGP
EIWEQMDGRVDAVVAGVGSGGTLTGLSRFFARVSPQTDIVLADPKGSILADYVTSGRIGAAGSWLVEGIGEDFVPPVSDL
SRVTHAYTIPDGESFATARGVLRQEGLLIGSSSGTLLAAALRYCREQTSPKRVVSFVCDSGNKYLSKMYNDFWMADQGLS
NRPRFGDLRDLIARRQDEGAVVSVAPGDTLAIAYQRMKLYDVSQLPVLDGTRCVGLIDESDVLLSLRERGGLFDVAVSAA
MSTDLETVGPDADADHLVGLFDRGRVAIVVDDSGFLGLITRIDFLNHLRGKAA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=394, Percent_Identity=37.3096446700508, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI295821200, Length=394, Percent_Identity=37.3096446700508, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI4557415, Length=394, Percent_Identity=37.3096446700508, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI11345492, Length=294, Percent_Identity=26.8707482993197, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=40.133779264214, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=41.5335463258786, Blast_Score=198, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=325, Percent_Identity=39.6923076923077, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=39.8692810457516, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=39.6666666666667, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=335, Percent_Identity=38.5074626865672, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=37.7300613496933, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=37.0860927152318, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=37.5415282392027, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=222, Percent_Identity=36.4864864864865, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71996324, Length=340, Percent_Identity=28.8235294117647, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=25.8720930232558, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17539640, Length=343, Percent_Identity=23.9067055393586, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=496, Percent_Identity=31.8548387096774, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6321449, Length=345, Percent_Identity=32.463768115942, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643623, Length=372, Percent_Identity=36.0215053763441, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129101, Length=372, Percent_Identity=36.0215053763441, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48692; Mature: 48561

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPVDLLAQIGHTPIVRLDHLDTGPCSLFVKLESQNPSGSIKDRIAVSMIDAAERDGRL
CCCHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
KPKGRIVEATAGNTGLALALVAARRGYHLTLVIPDKMSREKIAHVRAMGAEVVLTRSDIG
CCCCEEEEEECCCCCHHHHEEHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
KGHPAYYQDLAQRIADETGAFFTDQFNNPDNPIAHETGTGPEIWEQMDGRVDAVVAGVGS
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCC
GGTLTGLSRFFARVSPQTDIVLADPKGSILADYVTSGRIGAAGSWLVEGIGEDFVPPVSD
CCHHHHHHHHHHHCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHCCCCCCCCHHH
LSRVTHAYTIPDGESFATARGVLRQEGLLIGSSSGTLLAAALRYCREQTSPKRVVSFVCD
HHHHHEEEECCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHC
SGNKYLSKMYNDFWMADQGLSNRPRFGDLRDLIARRQDEGAVVSVAPGDTLAIAYQRMKL
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHEEHHHHE
YDVSQLPVLDGTRCVGLIDESDVLLSLRERGGLFDVAVSAAMSTDLETVGPDADADHLVG
ECCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEHHHHHHHHHCCCHHCCCCCCHHHHHH
LFDRGRVAIVVDDSGFLGLITRIDFLNHLRGKAA
HCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAPVDLLAQIGHTPIVRLDHLDTGPCSLFVKLESQNPSGSIKDRIAVSMIDAAERDGRL
CCHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
KPKGRIVEATAGNTGLALALVAARRGYHLTLVIPDKMSREKIAHVRAMGAEVVLTRSDIG
CCCCEEEEEECCCCCHHHHEEHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
KGHPAYYQDLAQRIADETGAFFTDQFNNPDNPIAHETGTGPEIWEQMDGRVDAVVAGVGS
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCC
GGTLTGLSRFFARVSPQTDIVLADPKGSILADYVTSGRIGAAGSWLVEGIGEDFVPPVSD
CCHHHHHHHHHHHCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHCCCCCCCCHHH
LSRVTHAYTIPDGESFATARGVLRQEGLLIGSSSGTLLAAALRYCREQTSPKRVVSFVCD
HHHHHEEEECCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHC
SGNKYLSKMYNDFWMADQGLSNRPRFGDLRDLIARRQDEGAVVSVAPGDTLAIAYQRMKL
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHEEHHHHE
YDVSQLPVLDGTRCVGLIDESDVLLSLRERGGLFDVAVSAAMSTDLETVGPDADADHLVG
ECCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEHHHHHHHHHCCCHHCCCCCCHHHHHH
LFDRGRVAIVVDDSGFLGLITRIDFLNHLRGKAA
HCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]