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The map label for this gene is hemA [H]

Identifier: 83592088

GI number: 83592088

Start: 877689

End: 879014

Strand: Direct

Name: hemA [H]

Synonym: Rru_A0749

Alternate gene names: 83592088

Gene position: 877689-879014 (Clockwise)

Preceding gene: 83592087

Following gene: 83592089

Centisome position: 20.16

GC content: 70.97

Gene sequence:

>1326_bases
GTGGCGCAGGAGCGGACGGCGGGATGCGGGGTGGACGGCTACGTGATGGTGGGGGTGAACCACCAGACCACGCCGATGGC
CCTGCGCGACCGCCTTGTTCTTGACGACCCCGCCCTGGCCGCCCTTCTGGTGCGGCTGCGCGCCCGCGGCGTGACCGAGG
CTTTGGCGCTATCGACCTGTGATCGCGTGGAGATCTTTGGTCATGGCGGCGATCCCCGCGCCTTGCGCGCCCTGCTGCTG
GCCGAGCTTTGCGCGGTTGGTCCTATCGAACCGGCGGCCCTGGCCGGTCAGATGGTCGATCTGCGCGGCTTGGCGGTTGT
CGCGCATATGTTTCGCATCACCTCGGCCCTGGAGAGCCAGGTTCTGGGCGAGCCCCATATTTTGGGGCAGGTCAAGGCCG
CCCACCGCATCGCCCGCGACGCCGGCACCGTTGGATCGGCGACCGAGGCCCTGATGCAGGCGGCCTATGCCATCGCCAAA
CGCGTGCGCAGCGAGACGCGCATTTCCGAAGGGCCGGTCAGTCTGGCCGCCGTCGCCGCCCAGATCGCCCGCGATCTTCA
CGGCGATCTTGGCGAAACCTGCCTGCTGCTGCTGGGCACCCAGGAGATGGGCGAGTTGATCGCCGAACAGCTTCAGATGG
CCGGTGTCGGCCGGCTGGTGGTCTGCGCCCCCCGGCGGCCGCGCGCCGAGGCGGTGGCGGCGCGGCTGGGGGCGAGTGTC
GGCGATCACGGGGCCTTGCTTGATCTGCTGCCCAATGCCGATATCGTCGTCGTCGGCGTTGGCGGCGGGCTGCTGGCCCT
GGGCGAGGAGGCCATGCGCCGCACCTTGAAGCGCCGCCGCAACCGGCCTGTCTTCATCGTCGACGCCGGGGTGCCGGGCA
ATGTCGAGCCGTCGGTCCAGCGGCTGGAGGCGGCCTTTCTCTACGATCTGGCCGATCTGGAGGCGGTGGCCGAGGAAGGG
CGGGCGGCCCGCGATCAGGCGTCGCGCGAGGCCCACGCCCTGGTGGCCGATGCGGTCGCCGCCTTTGAGCGCCACCGGGC
CGAACGGGCCGCCGTGCCGGCGATCGCCGCCCTGCGCGCCCATTTCGAGGGCGAGCGTCTGCGCGCCCTGGCCGAGGCCC
CCGACGATGCGGAAAAGGCCACCCGGCTGCTGGTCGGACGCCTGCTGCATGGGCCGAGCGAGGCCTTGCGCGATCTGGCG
GCGGGATCGGCCGACAAGGAATTCATGACGGTGCGGGCGGAGATGCTGCTGCGGCGGCTGTTTGACCTGCCCACGAGCAT
CGCCGAAACGGGCGCAACCGACCGGGAGGATGGGTCGAAGGGATGA

Upstream 100 bases:

>100_bases
TCGTGCGCGATCTTGACAGCGGCGAGCAGGAAACCATCGGCCTTGCTGTGCTGGAGGAGTTCCTGGCCCGGTTCCTCTAG
CTTATCGGAGGGGAGAGCGG

Downstream 100 bases:

>100_bases
GTTTGGAAGAGAACCTGAGCCGCGTGGTCGCCCGGCACGATGAATTGCGCGCCCTGCTGTCGACCAGCGCCGGCGGCGGC
GAGGGCTTCGTGCGCATGTC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTCDRVEIFGHGGDPRALRALLL
AELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQVLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAK
RVRSETRISEGPVSLAAVAAQIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASV
GDHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQRLEAAFLYDLADLEAVAEEG
RAARDQASREAHALVADAVAAFERHRAERAAVPAIAALRAHFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLA
AGSADKEFMTVRAEMLLRRLFDLPTSIAETGATDREDGSKG

Sequences:

>Translated_441_residues
MAQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTCDRVEIFGHGGDPRALRALLL
AELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQVLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAK
RVRSETRISEGPVSLAAVAAQIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASV
GDHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQRLEAAFLYDLADLEAVAEEG
RAARDQASREAHALVADAVAAFERHRAERAAVPAIAALRAHFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLA
AGSADKEFMTVRAEMLLRRLFDLPTSIAETGATDREDGSKG
>Mature_440_residues
AQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTCDRVEIFGHGGDPRALRALLLA
ELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQVLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAKR
VRSETRISEGPVSLAAVAAQIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASVG
DHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQRLEAAFLYDLADLEAVAEEGR
AARDQASREAHALVADAVAAFERHRAERAAVPAIAALRAHFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLAA
GSADKEFMTVRAEMLLRRLFDLPTSIAETGATDREDGSKG

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=409, Percent_Identity=32.518337408313, Blast_Score=183, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 46570; Mature: 46439

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTC
CCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCC
DRVEIFGHGGDPRALRALLLAELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQ
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAKRVRSETRISEGPVSLAAVAA
HCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCC
GDHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQ
CCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
RLEAAFLYDLADLEAVAEEGRAARDQASREAHALVADAVAAFERHRAERAAVPAIAALRA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLAAGSADKEFMTVRAEMLLRRL
HCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FDLPTSIAETGATDREDGSKG
HHCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTC
CCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCC
DRVEIFGHGGDPRALRALLLAELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQ
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAKRVRSETRISEGPVSLAAVAA
HCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCC
GDHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQ
CCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
RLEAAFLYDLADLEAVAEEGRAARDQASREAHALVADAVAAFERHRAERAAVPAIAALRA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLAAGSADKEFMTVRAEMLLRRL
HCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FDLPTSIAETGATDREDGSKG
HHCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA