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The map label for this gene is glcD [H]

Identifier: 83591129

GI number: 83591129

Start: 2426773

End: 2428173

Strand: Reverse

Name: glcD [H]

Synonym: Moth_2308

Alternate gene names: 83591129

Gene position: 2428173-2426773 (Counterclockwise)

Preceding gene: 83591130

Following gene: 83591128

Centisome position: 92.37

GC content: 59.6

Gene sequence:

>1401_bases
TTGACGGCGCAAAAGGAATTGCTGAAGAAACTGGAAGGTATCCTGGGTCGGGAACGGCTCATCACGGAAGCGGAGGACCG
CTGGTGCTACGCCTTTGATGCTGCGGCCGCCCAGGCCAAACACCTGCCCCTGGCCGTGGCCCTGCCGCGGTCGACGGAAG
AAGTGGTAGCCATTATGCGCCTGGCTACGGAGTACCGGGTGCCGGTTTACCCCCGGGGTGCAGGTACCAATTTGAGCGGC
GGGGTCATTCCCCGGGAAGATGGCTTGGTCGTCTCTTTTACCGAGATGAACAAGATCCTGGAGCTGGATATTGAAAACTT
GACAGCCACCGTTCAGCCGGGGGTGGTTGTCCAGGACCTTAATGACGCCGTCGCCCCCCATGGTCTTATCTACCCGCCCG
ATCCCGGAAGTGTGACCACTGCTACCATGGGCGGTAGCGTGGCAGAGTCCTCGGGGGGCCTGCGGGGCCTCAAGTACGGG
GTTACCAAGGATTATGTCATGGGGCTGGAGGTCGTTCTGGCCGACGGCACCGTCTTTCATTGCGGTGGGAAGACAGTAAA
GAATGTTAGCGGCTACGATCTGGTGAAACTTTTCTGCGGTAGTGAGGGAACCCTGGGGATCATGACGGCCATTACCGTGC
GCCTGATCCCGGCGCCGGAAGCTCGGCGGAGCATGCTGGCCGTCTTTGACCGGATGGAGGGGGCCGCCAGGACCATCACC
GAGATCATCGCCAACAAGGTTATACCTGCTACTATGGAAATTATGGATAATGTTACCATTCGTACAGTGGAGGCATACTG
CCACGCCGGCCTTCCGGTAGAGGCGGCGGCCGTACTCCTGCTGGAAGTGGACGGTATTCCAGAGGTTGTCGCCAAAGAGG
CGGCTATCGTTGAACGGGTCTGCCGGGAAAACGGCGGCCAGGTCCAGGTCGCCCGGGACGATGCCGAACGGGAAAACCTG
TGGACCGCCCGCCGGGCTGCCCTGCCGGCCTGTGCACGCCTGCGGCCCACTACCGTATTGGAAGACGCCACTGTTCCCCG
TAGCCAGATACCAGCTATGCTCCTGGCTCTGGAGAAGATTGCCCAAAAATATAACCTGACCATCGCCACTTATGGCCATG
CCGGCGACGGCAACCTGCACCCAACCATTACCTGTGACGAGCGGGATGGGGAAGAAATGCAGCGAGTACACAGTGCCGTC
GATGAGATTTTCCGTACTGCCGTTGAACTGGGCGGAACCTTAAGCGGTGAACATGGTATCGGTATTGCCAAGCAGAAGTA
TATGGAACTCGAGTTTGGCGCCAACGGCCTGGACGTCATGCGCCGGATCAAGCAAGCCCTGGATCCCCTGGGGTTACTCA
ATCCCGGCAAACTCGTTGGTCCGGTCCCAGCGAAGGAGTGA

Upstream 100 bases:

>100_bases
CCAGACAAAATTGACAGACCATTAAGAGCCTTAAGATATTGTGACAACAAGCACATGGTAGCTGGCCAGAGGCGAAATTC
ATAGGGGGGAGGCTTAAGCC

Downstream 100 bases:

>100_bases
GGGGCCGTGAGCTATTTAGATGACCTGGCCCTGGTTGGCGAAGAAATGGCCAAGTGCATGAAGTGCGGCAACTGCCAGGC
AGTCTGCCCTCTGTATAAAG

Product: FAD linked oxidase-like

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTAQKELLKKLEGILGRERLITEAEDRWCYAFDAAAAQAKHLPLAVALPRSTEEVVAIMRLATEYRVPVYPRGAGTNLSG
GVIPREDGLVVSFTEMNKILELDIENLTATVQPGVVVQDLNDAVAPHGLIYPPDPGSVTTATMGGSVAESSGGLRGLKYG
VTKDYVMGLEVVLADGTVFHCGGKTVKNVSGYDLVKLFCGSEGTLGIMTAITVRLIPAPEARRSMLAVFDRMEGAARTIT
EIIANKVIPATMEIMDNVTIRTVEAYCHAGLPVEAAAVLLLEVDGIPEVVAKEAAIVERVCRENGGQVQVARDDAERENL
WTARRAALPACARLRPTTVLEDATVPRSQIPAMLLALEKIAQKYNLTIATYGHAGDGNLHPTITCDERDGEEMQRVHSAV
DEIFRTAVELGGTLSGEHGIGIAKQKYMELEFGANGLDVMRRIKQALDPLGLLNPGKLVGPVPAKE

Sequences:

>Translated_466_residues
MTAQKELLKKLEGILGRERLITEAEDRWCYAFDAAAAQAKHLPLAVALPRSTEEVVAIMRLATEYRVPVYPRGAGTNLSG
GVIPREDGLVVSFTEMNKILELDIENLTATVQPGVVVQDLNDAVAPHGLIYPPDPGSVTTATMGGSVAESSGGLRGLKYG
VTKDYVMGLEVVLADGTVFHCGGKTVKNVSGYDLVKLFCGSEGTLGIMTAITVRLIPAPEARRSMLAVFDRMEGAARTIT
EIIANKVIPATMEIMDNVTIRTVEAYCHAGLPVEAAAVLLLEVDGIPEVVAKEAAIVERVCRENGGQVQVARDDAERENL
WTARRAALPACARLRPTTVLEDATVPRSQIPAMLLALEKIAQKYNLTIATYGHAGDGNLHPTITCDERDGEEMQRVHSAV
DEIFRTAVELGGTLSGEHGIGIAKQKYMELEFGANGLDVMRRIKQALDPLGLLNPGKLVGPVPAKE
>Mature_465_residues
TAQKELLKKLEGILGRERLITEAEDRWCYAFDAAAAQAKHLPLAVALPRSTEEVVAIMRLATEYRVPVYPRGAGTNLSGG
VIPREDGLVVSFTEMNKILELDIENLTATVQPGVVVQDLNDAVAPHGLIYPPDPGSVTTATMGGSVAESSGGLRGLKYGV
TKDYVMGLEVVLADGTVFHCGGKTVKNVSGYDLVKLFCGSEGTLGIMTAITVRLIPAPEARRSMLAVFDRMEGAARTITE
IIANKVIPATMEIMDNVTIRTVEAYCHAGLPVEAAAVLLLEVDGIPEVVAKEAAIVERVCRENGGQVQVARDDAERENLW
TARRAALPACARLRPTTVLEDATVPRSQIPAMLLALEKIAQKYNLTIATYGHAGDGNLHPTITCDERDGEEMQRVHSAVD
EIFRTAVELGGTLSGEHGIGIAKQKYMELEFGANGLDVMRRIKQALDPLGLLNPGKLVGPVPAKE

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=461, Percent_Identity=34.9240780911063, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI37595754, Length=484, Percent_Identity=33.2644628099174, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI119964728, Length=419, Percent_Identity=31.980906921241, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501993, Length=253, Percent_Identity=29.2490118577075, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1789351, Length=452, Percent_Identity=40.7079646017699, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1787977, Length=518, Percent_Identity=25.8687258687259, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI48994907, Length=487, Percent_Identity=25.2566735112936, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI48994914, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=466, Percent_Identity=33.0472103004292, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71992381, Length=467, Percent_Identity=31.9057815845824, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI71992392, Length=362, Percent_Identity=33.7016574585635, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17534361, Length=474, Percent_Identity=29.3248945147679, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17556096, Length=221, Percent_Identity=31.6742081447964, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=447, Percent_Identity=32.2147651006711, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6320023, Length=478, Percent_Identity=28.6610878661088, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320764, Length=429, Percent_Identity=28.6713286713287, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI18921117, Length=463, Percent_Identity=27.645788336933, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24639277, Length=463, Percent_Identity=27.645788336933, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24639275, Length=463, Percent_Identity=27.645788336933, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24653753, Length=476, Percent_Identity=25.8403361344538, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50008; Mature: 49877

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQKELLKKLEGILGRERLITEAEDRWCYAFDAAAAQAKHLPLAVALPRSTEEVVAIMR
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCEEEECCCCHHHHHHHHH
LATEYRVPVYPRGAGTNLSGGVIPREDGLVVSFTEMNKILELDIENLTATVQPGVVVQDL
HHHHCCCCEECCCCCCCCCCCCCCCCCCEEEEHHHHCHHHEEEHHHCEEECCCCEEEECC
NDAVAPHGLIYPPDPGSVTTATMGGSVAESSGGLRGLKYGVTKDYVMGLEVVLADGTVFH
HHHCCCCCEEECCCCCCEEEEECCCCHHCCCCCCCEEECCCCHHHHHCEEEEEECCEEEE
CGGKTVKNVSGYDLVKLFCGSEGTLGIMTAITVRLIPAPEARRSMLAVFDRMEGAARTIT
CCCCCCCCCCCCCEEEEEECCCCCEEHEEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHH
EIIANKVIPATMEIMDNVTIRTVEAYCHAGLPVEAAAVLLLEVDGIPEVVAKEAAIVERV
HHHHHCCCHHHHHHHCCCCEEEEEHHHCCCCCHHHEEEEEEEECCCHHHHHHHHHHHHHH
CRENGGQVQVARDDAERENLWTARRAALPACARLRPTTVLEDATVPRSQIPAMLLALEKI
HHCCCCEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCEECCCCCCHHHHHHHHHHHHHH
AQKYNLTIATYGHAGDGNLHPTITCDERDGEEMQRVHSAVDEIFRTAVELGGTLSGEHGI
HHHHCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GIAKQKYMELEFGANGLDVMRRIKQALDPLGLLNPGKLVGPVPAKE
CHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
TAQKELLKKLEGILGRERLITEAEDRWCYAFDAAAAQAKHLPLAVALPRSTEEVVAIMR
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCEEEECCCCHHHHHHHHH
LATEYRVPVYPRGAGTNLSGGVIPREDGLVVSFTEMNKILELDIENLTATVQPGVVVQDL
HHHHCCCCEECCCCCCCCCCCCCCCCCCEEEEHHHHCHHHEEEHHHCEEECCCCEEEECC
NDAVAPHGLIYPPDPGSVTTATMGGSVAESSGGLRGLKYGVTKDYVMGLEVVLADGTVFH
HHHCCCCCEEECCCCCCEEEEECCCCHHCCCCCCCEEECCCCHHHHHCEEEEEECCEEEE
CGGKTVKNVSGYDLVKLFCGSEGTLGIMTAITVRLIPAPEARRSMLAVFDRMEGAARTIT
CCCCCCCCCCCCCEEEEEECCCCCEEHEEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHH
EIIANKVIPATMEIMDNVTIRTVEAYCHAGLPVEAAAVLLLEVDGIPEVVAKEAAIVERV
HHHHHCCCHHHHHHHCCCCEEEEEHHHCCCCCHHHEEEEEEEECCCHHHHHHHHHHHHHH
CRENGGQVQVARDDAERENLWTARRAALPACARLRPTTVLEDATVPRSQIPAMLLALEKI
HHCCCCEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCEECCCCCCHHHHHHHHHHHHHH
AQKYNLTIATYGHAGDGNLHPTITCDERDGEEMQRVHSAVDEIFRTAVELGGTLSGEHGI
HHHHCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GIAKQKYMELEFGANGLDVMRRIKQALDPLGLLNPGKLVGPVPAKE
CHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]