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The map label for this gene is ilvD

Identifier: 83591080

GI number: 83591080

Start: 2364747

End: 2366405

Strand: Reverse

Name: ilvD

Synonym: Moth_2259

Alternate gene names: 83591080

Gene position: 2366405-2364747 (Counterclockwise)

Preceding gene: 83591081

Following gene: 83591079

Centisome position: 90.02

GC content: 59.86

Gene sequence:

>1659_bases
GTGCGCAGCGATGCTATGAAAACGGGCCTGGCCCGGGCTCCCCACAGATCGTTACTTAAAGCCATGGGCCTGACCGAGAC
GGAAATCGAGCGGCCGATTATAGGTGTTGTCAATGCCCATAATGAACTCATTCCCGGCCATATACATTTAAATAACCTGG
TGGAAGCCGTAAAAGCAGGGGTGCGCCTGGCCGGCGGTACGCCCCTGGAGTTTCCCACTATCGGTGTCTGTGATGGCCTG
GCCATGAACCATGTGGGGATGAAGTATTCCCTGGCCAGCCGGGAGCTCATCGCCGATATGATTGAAGTAATGGCTATGGC
CCATCCCTTTGACGCCCTGGTATTTATCCCTAACTGCGATAAGATCGTCCCCGGGATGCTTATGGCAGCAGCCCGCCTGA
ACCTCCCTGCCATTTTTATCAGCGGCGGTCCCATGCTGGCCGGCCGTTACCAGGGCCGGGATGTTTCCCTGAGTACTATG
TTCGAGGCTGTAGGGGCTGTCCAGGCCGGGAAGATGACAGAACAGGAACTGGCCGCCCTGGAGGACTGCGCCTGCCCGGG
CTGTGGTTCCTGTGCGGGTATGTTTACCGCCAACACCATGAACTGCATGGTTGAGGCCTTAGGGATGGGCCTGCCGGGTA
ACGGTACTACCCCTGCAGTGAGCGGCTCCCGGGTACGTTTGGCTAAAGAAGCCGGTATGCAGGTGATGAAATTACTCCAG
GAAAATATCCGGCCCCTGGATATTATGACGGCTACAGCCTTCCGCAATGCCGTGGCCGTGGATATGGCCCTGGGTGGTTC
GACCAATACCTGCCTGCACCTGCCGGCCATAGCCCATGAAGCCGGCGTAAAACTTGACCTGAATACTTTCAACGAAATCA
ATCGGCGGACGCCCCAGATCTGTAAGCTCAGCCCGGCCGGCAGCCAGCACATCCAGGACCTGGATGAGGCCGGCGGTATC
CCGGCGGTGATGAATGAGCTCTACCGTCATGGCCTGATTGACGGCAGCGCCCTTACTGTGACCGGACGGACAGTGGCTGA
TAACGTCAGCGGTCGGGTGGTAAGCCGGCGCGAGGTTATCCGGCCTGTGGAAGACCCCTACAGCAGGGAAGGTGGCCTGG
CCGTATTGTATGGCAACCTGGCTCCTGAGGGTGCCGTTGTAAAGAAGGGCGCCGTGCTGCCGGAGATGATGCGGCATGAA
GGGCCGGCGCGGGTATTTAACAGCGAGGAAGAGGCTTTTGCCGCCATTATGGGGAAGCAGATTAAACCCGGGGATGTGGT
GGTAATCCGCTACGAAGGCCCTCGTGGCGGTCCGGGTATGCAGGAAATGCTCAGTCCCACGGCAGCCCTGGCCGGTATGG
GCTTGGACAGCTCCGTGGCTCTGATCACTGACGGCCGTTTCTCCGGTGCCAGCCGTGGCGCCTCTATCGGTCACGTCTCG
CCGGAAGCAGCGGCCGGGGGGCTCATCGCCCTGGTGGAAGAAGGAGATATCATCGCCATCGATATTGAAGCCGGCAAGCT
GGAACTTAAGGTGCCGGAAGAAGAAATTGCCCGCCGCCGCCAGAATTGGCAGGCGCCGCCGCCGAAGATCACCGGCGGTT
ACCTGGGCCGCTACGCGCGCATGGTTACTTCCGGAGCCAGGGGCGCGGTGTTGGAGTAA

Upstream 100 bases:

>100_bases
CCAGCCGGGCCCCATAACCAGGGATCTCATTGCCCGGTACCGTGAGTTAACTAAAACCGACGGTCCGAAAATCTTTGCCT
GATCAAGGGAGAGGAAAACC

Downstream 100 bases:

>100_bases
AATATTTTAAGCGCAAAGGGGTGCTTTTTACCATTGGGGATCGAGCTGAAGGCAAAAAACTAACCGGAGCGGAGATTATT
GTTCAGGCCCTCCAGGCAGA

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MRSDAMKTGLARAPHRSLLKAMGLTETEIERPIIGVVNAHNELIPGHIHLNNLVEAVKAGVRLAGGTPLEFPTIGVCDGL
AMNHVGMKYSLASRELIADMIEVMAMAHPFDALVFIPNCDKIVPGMLMAAARLNLPAIFISGGPMLAGRYQGRDVSLSTM
FEAVGAVQAGKMTEQELAALEDCACPGCGSCAGMFTANTMNCMVEALGMGLPGNGTTPAVSGSRVRLAKEAGMQVMKLLQ
ENIRPLDIMTATAFRNAVAVDMALGGSTNTCLHLPAIAHEAGVKLDLNTFNEINRRTPQICKLSPAGSQHIQDLDEAGGI
PAVMNELYRHGLIDGSALTVTGRTVADNVSGRVVSRREVIRPVEDPYSREGGLAVLYGNLAPEGAVVKKGAVLPEMMRHE
GPARVFNSEEEAFAAIMGKQIKPGDVVVIRYEGPRGGPGMQEMLSPTAALAGMGLDSSVALITDGRFSGASRGASIGHVS
PEAAAGGLIALVEEGDIIAIDIEAGKLELKVPEEEIARRRQNWQAPPPKITGGYLGRYARMVTSGARGAVLE

Sequences:

>Translated_552_residues
MRSDAMKTGLARAPHRSLLKAMGLTETEIERPIIGVVNAHNELIPGHIHLNNLVEAVKAGVRLAGGTPLEFPTIGVCDGL
AMNHVGMKYSLASRELIADMIEVMAMAHPFDALVFIPNCDKIVPGMLMAAARLNLPAIFISGGPMLAGRYQGRDVSLSTM
FEAVGAVQAGKMTEQELAALEDCACPGCGSCAGMFTANTMNCMVEALGMGLPGNGTTPAVSGSRVRLAKEAGMQVMKLLQ
ENIRPLDIMTATAFRNAVAVDMALGGSTNTCLHLPAIAHEAGVKLDLNTFNEINRRTPQICKLSPAGSQHIQDLDEAGGI
PAVMNELYRHGLIDGSALTVTGRTVADNVSGRVVSRREVIRPVEDPYSREGGLAVLYGNLAPEGAVVKKGAVLPEMMRHE
GPARVFNSEEEAFAAIMGKQIKPGDVVVIRYEGPRGGPGMQEMLSPTAALAGMGLDSSVALITDGRFSGASRGASIGHVS
PEAAAGGLIALVEEGDIIAIDIEAGKLELKVPEEEIARRRQNWQAPPPKITGGYLGRYARMVTSGARGAVLE
>Mature_552_residues
MRSDAMKTGLARAPHRSLLKAMGLTETEIERPIIGVVNAHNELIPGHIHLNNLVEAVKAGVRLAGGTPLEFPTIGVCDGL
AMNHVGMKYSLASRELIADMIEVMAMAHPFDALVFIPNCDKIVPGMLMAAARLNLPAIFISGGPMLAGRYQGRDVSLSTM
FEAVGAVQAGKMTEQELAALEDCACPGCGSCAGMFTANTMNCMVEALGMGLPGNGTTPAVSGSRVRLAKEAGMQVMKLLQ
ENIRPLDIMTATAFRNAVAVDMALGGSTNTCLHLPAIAHEAGVKLDLNTFNEINRRTPQICKLSPAGSQHIQDLDEAGGI
PAVMNELYRHGLIDGSALTVTGRTVADNVSGRVVSRREVIRPVEDPYSREGGLAVLYGNLAPEGAVVKKGAVLPEMMRHE
GPARVFNSEEEAFAAIMGKQIKPGDVVVIRYEGPRGGPGMQEMLSPTAALAGMGLDSSVALITDGRFSGASRGASIGHVS
PEAAAGGLIALVEEGDIIAIDIEAGKLELKVPEEEIARRRQNWQAPPPKITGGYLGRYARMVTSGARGAVLE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=42.9042904290429, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1788157, Length=520, Percent_Identity=33.4615384615385, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1786464, Length=527, Percent_Identity=33.965844402277, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI2367371, Length=502, Percent_Identity=32.8685258964143, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322476, Length=547, Percent_Identity=41.8647166361974, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_MOOTA (Q2RG93)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431089.1
- STRING:   Q2RG93
- GeneID:   3830754
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2259
- NMPDR:   fig|264732.9.peg.2290
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   SIERNAC
- PhylomeDB:   Q2RG93
- BioCyc:   MTHE264732:MOTH_2259-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58121; Mature: 58121

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDAMKTGLARAPHRSLLKAMGLTETEIERPIIGVVNAHNELIPGHIHLNNLVEAVKAG
CCCHHHHHHHCCCCHHHHHHHHCCCHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHHC
VRLAGGTPLEFPTIGVCDGLAMNHVGMKYSLASRELIADMIEVMAMAHPFDALVFIPNCD
EEECCCCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
KIVPGMLMAAARLNLPAIFISGGPMLAGRYQGRDVSLSTMFEAVGAVQAGKMTEQELAAL
HHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
EDCACPGCGSCAGMFTANTMNCMVEALGMGLPGNGTTPAVSGSRVRLAKEAGMQVMKLLQ
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
ENIRPLDIMTATAFRNAVAVDMALGGSTNTCLHLPAIAHEAGVKLDLNTFNEINRRTPQI
HCCCCEEEEHHHHHHCCEEEEEEECCCCCCEEECCHHHHHCCCEEECHHHHHHHCCCCCE
CKLSPAGSQHIQDLDEAGGIPAVMNELYRHGLIDGSALTVTGRTVADNVSGRVVSRREVI
EEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCEECHHHHH
RPVEDPYSREGGLAVLYGNLAPEGAVVKKGAVLPEMMRHEGPARVFNSEEEAFAAIMGKQ
CCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCHHHCCCHHHHHHHHHCCC
IKPGDVVVIRYEGPRGGPGMQEMLSPTAALAGMGLDSSVALITDGRFSGASRGASIGHVS
CCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC
PEAAAGGLIALVEEGDIIAIDIEAGKLELKVPEEEIARRRQNWQAPPPKITGGYLGRYAR
CHHHCCCEEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MVTSGARGAVLE
HHHCCCCCCCCC
>Mature Secondary Structure
MRSDAMKTGLARAPHRSLLKAMGLTETEIERPIIGVVNAHNELIPGHIHLNNLVEAVKAG
CCCHHHHHHHCCCCHHHHHHHHCCCHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHHC
VRLAGGTPLEFPTIGVCDGLAMNHVGMKYSLASRELIADMIEVMAMAHPFDALVFIPNCD
EEECCCCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
KIVPGMLMAAARLNLPAIFISGGPMLAGRYQGRDVSLSTMFEAVGAVQAGKMTEQELAAL
HHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
EDCACPGCGSCAGMFTANTMNCMVEALGMGLPGNGTTPAVSGSRVRLAKEAGMQVMKLLQ
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
ENIRPLDIMTATAFRNAVAVDMALGGSTNTCLHLPAIAHEAGVKLDLNTFNEINRRTPQI
HCCCCEEEEHHHHHHCCEEEEEEECCCCCCEEECCHHHHHCCCEEECHHHHHHHCCCCCE
CKLSPAGSQHIQDLDEAGGIPAVMNELYRHGLIDGSALTVTGRTVADNVSGRVVSRREVI
EEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCEECHHHHH
RPVEDPYSREGGLAVLYGNLAPEGAVVKKGAVLPEMMRHEGPARVFNSEEEAFAAIMGKQ
CCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCHHHCCCHHHHHHHHHCCC
IKPGDVVVIRYEGPRGGPGMQEMLSPTAALAGMGLDSSVALITDGRFSGASRGASIGHVS
CCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC
PEAAAGGLIALVEEGDIIAIDIEAGKLELKVPEEEIARRRQNWQAPPPKITGGYLGRYAR
CHHHCCCEEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MVTSGARGAVLE
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA