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The map label for this gene is moeA [C]

Identifier: 83590962

GI number: 83590962

Start: 2233430

End: 2234653

Strand: Reverse

Name: moeA [C]

Synonym: Moth_2136

Alternate gene names: 83590962

Gene position: 2234653-2233430 (Counterclockwise)

Preceding gene: 83590963

Following gene: 83590961

Centisome position: 85.01

GC content: 64.38

Gene sequence:

>1224_bases
TTGCTATTGGCACGCAAGGTCTTTGTCCCCAGCCGGCCCTGGCAGGAGGCCCTGGAGGAATTTCTGGGAGCTTTAAGGTC
CAGCGGCTACCTGGCCGGGTTGCCGACTGAAGAAATAGACGTTACCCAGGCCCTGGGACGGGTGACGGCGGCTCCTGTCT
ATGCCGCCATCTCCTCGCCCCATTATCCGGCCGCAGCCATGGACGGCATCGCCGTCCGGGCGGAAACGACCTTTGGCGCC
AGTGAACAGGAACCCCTGGAACTGGCCCTGGACCGGGAAGCCGTGGTTGTAGATACCGGCGACCCCCTGCCGGAAGGCTT
TGATGCCGTCATTATGGTGGAAGAGGTTGCCTTCCAGGATAAAACTACCGCCATTATCAAGCGACCGGCCGTCCCGGGGC
AGAATGTCCGGCCTGTGGGGGAAGATATCACCGCCGGGGAGATGCTGGTGCCGGCAGGCCACAGCCTGACCCCTTATGAC
CTGGGTGGCCTCCTTGCCGCCGGGGTTACCAGGGTGACCGTCCGGCCCCGGCCGCGGGTGGCCATCCTGCCCACGGGTAC
GGAGATTGTACCGCCGAATCCCAACCCGGCCCCCGGGGAGATCCTGGAATCCAACGGCACCATGCTGGCCGCCCTGGTGA
GCCAGTGGGGCGGCGTGCCGGAGGTTTACCCTATCACCCCTGACGATTACCAGCTTTTAAAAGAACGCCTGGACCGGGCC
CTGGAGGAAAAGGACCTGGTGCTCATCAATGCCGGTTCCTCAGCCGGCCGCGATGATTATACGGCCCGCCTGGTAGAAGA
AACGGGACACCTCCTGACCCACGGTGTGGCTACCAGGCCGGGCAAACCTGTAATCCTGGGGATCGTCAGGGATAAGCCGG
TGATCGGCGTGCCCGGTTACCCGGTATCGGCCGCCCTCTGCGCCGAACTCTTCGCCAAGCCGGTCCTTTATTACCGCCAG
GGTATCAAACCACCGGCACGGGAACAGGTGCGGGCCGTCCTGGGCCGTAAGATCCATTCCCCCCTGGGCCGGGAAGAGTT
TGTCCGCGTCCGCCTGGAATGGGAGGGGGACAGGCTGGTGGCTACTCCTACTTCGCGGGGGGCAGGAACGATCATGGCCC
TGGCCCGGGCCGACGGCATAGTGGTGGTCCCGCGTTTGTCCGAAGGTTTCCCCGCCGGGCAGGAAGTAACGGTCAATCTC
CTGCGGCCCCTATCAGGCCGCTAG

Upstream 100 bases:

>100_bases
CTTTATGATACAATGGTCCATAAAACGGAGAGAAAGCGGAGAGAAACCGGAGAGGGTCCGGAAAGTCTGATTAAGTTGTA
TTAAACCCCTGGAGGAAGGG

Downstream 100 bases:

>100_bases
CACCCTGCCCGGTACATATATTGGGGGCTGGCAGGTTGCATTTTCAGGGAATGCGTTAGCAGGGAGGCCCCGGGCGGTAT
TTGTCTAGAGGCAGGACCAT

Product: molybdopterin binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLLARKVFVPSRPWQEALEEFLGALRSSGYLAGLPTEEIDVTQALGRVTAAPVYAAISSPHYPAAAMDGIAVRAETTFGA
SEQEPLELALDREAVVVDTGDPLPEGFDAVIMVEEVAFQDKTTAIIKRPAVPGQNVRPVGEDITAGEMLVPAGHSLTPYD
LGGLLAAGVTRVTVRPRPRVAILPTGTEIVPPNPNPAPGEILESNGTMLAALVSQWGGVPEVYPITPDDYQLLKERLDRA
LEEKDLVLINAGSSAGRDDYTARLVEETGHLLTHGVATRPGKPVILGIVRDKPVIGVPGYPVSAALCAELFAKPVLYYRQ
GIKPPAREQVRAVLGRKIHSPLGREEFVRVRLEWEGDRLVATPTSRGAGTIMALARADGIVVVPRLSEGFPAGQEVTVNL
LRPLSGR

Sequences:

>Translated_407_residues
MLLARKVFVPSRPWQEALEEFLGALRSSGYLAGLPTEEIDVTQALGRVTAAPVYAAISSPHYPAAAMDGIAVRAETTFGA
SEQEPLELALDREAVVVDTGDPLPEGFDAVIMVEEVAFQDKTTAIIKRPAVPGQNVRPVGEDITAGEMLVPAGHSLTPYD
LGGLLAAGVTRVTVRPRPRVAILPTGTEIVPPNPNPAPGEILESNGTMLAALVSQWGGVPEVYPITPDDYQLLKERLDRA
LEEKDLVLINAGSSAGRDDYTARLVEETGHLLTHGVATRPGKPVILGIVRDKPVIGVPGYPVSAALCAELFAKPVLYYRQ
GIKPPAREQVRAVLGRKIHSPLGREEFVRVRLEWEGDRLVATPTSRGAGTIMALARADGIVVVPRLSEGFPAGQEVTVNL
LRPLSGR
>Mature_407_residues
MLLARKVFVPSRPWQEALEEFLGALRSSGYLAGLPTEEIDVTQALGRVTAAPVYAAISSPHYPAAAMDGIAVRAETTFGA
SEQEPLELALDREAVVVDTGDPLPEGFDAVIMVEEVAFQDKTTAIIKRPAVPGQNVRPVGEDITAGEMLVPAGHSLTPYD
LGGLLAAGVTRVTVRPRPRVAILPTGTEIVPPNPNPAPGEILESNGTMLAALVSQWGGVPEVYPITPDDYQLLKERLDRA
LEEKDLVLINAGSSAGRDDYTARLVEETGHLLTHGVATRPGKPVILGIVRDKPVIGVPGYPVSAALCAELFAKPVLYYRQ
GIKPPAREQVRAVLGRKIHSPLGREEFVRVRLEWEGDRLVATPTSRGAGTIMALARADGIVVVPRLSEGFPAGQEVTVNL
LRPLSGR

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=382, Percent_Identity=30.8900523560209, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI10880983, Length=382, Percent_Identity=30.8900523560209, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1787049, Length=371, Percent_Identity=30.4582210242588, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147659, Length=337, Percent_Identity=31.4540059347181, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=336, Percent_Identity=25.297619047619, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136978, Length=354, Percent_Identity=29.3785310734463, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24638841, Length=354, Percent_Identity=29.3785310734463, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43482; Mature: 43482

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLARKVFVPSRPWQEALEEFLGALRSSGYLAGLPTEEIDVTQALGRVTAAPVYAAISSP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHEECCCC
HYPAAAMDGIAVRAETTFGASEQEPLELALDREAVVVDTGDPLPEGFDAVIMVEEVAFQD
CCCCHHHCCEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCEEEEEEHHHHCC
KTTAIIKRPAVPGQNVRPVGEDITAGEMLVPAGHSLTPYDLGGLLAAGVTRVTVRPRPRV
CCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCE
AILPTGTEIVPPNPNPAPGEILESNGTMLAALVSQWGGVPEVYPITPDDYQLLKERLDRA
EEEECCCEEECCCCCCCCCCEECCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LEEKDLVLINAGSSAGRDDYTARLVEETGHLLTHGVATRPGKPVILGIVRDKPVIGVPGY
HCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCEECCCCC
PVSAALCAELFAKPVLYYRQGIKPPAREQVRAVLGRKIHSPLGREEFVRVRLEWEGDRLV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEE
ATPTSRGAGTIMALARADGIVVVPRLSEGFPAGQEVTVNLLRPLSGR
ECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCHHHHEECCCCCCC
>Mature Secondary Structure
MLLARKVFVPSRPWQEALEEFLGALRSSGYLAGLPTEEIDVTQALGRVTAAPVYAAISSP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHEECCCC
HYPAAAMDGIAVRAETTFGASEQEPLELALDREAVVVDTGDPLPEGFDAVIMVEEVAFQD
CCCCHHHCCEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCEEEEEEHHHHCC
KTTAIIKRPAVPGQNVRPVGEDITAGEMLVPAGHSLTPYDLGGLLAAGVTRVTVRPRPRV
CCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCE
AILPTGTEIVPPNPNPAPGEILESNGTMLAALVSQWGGVPEVYPITPDDYQLLKERLDRA
EEEECCCEEECCCCCCCCCCEECCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LEEKDLVLINAGSSAGRDDYTARLVEETGHLLTHGVATRPGKPVILGIVRDKPVIGVPGY
HCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCEECCCCC
PVSAALCAELFAKPVLYYRQGIKPPAREQVRAVLGRKIHSPLGREEFVRVRLEWEGDRLV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEE
ATPTSRGAGTIMALARADGIVVVPRLSEGFPAGQEVTVNLLRPLSGR
ECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]