Click here to switch to the map view.

The map label for this gene is moeA [C]

Identifier: 83590963

GI number: 83590963

Start: 2234786

End: 2236015

Strand: Reverse

Name: moeA [C]

Synonym: Moth_2137

Alternate gene names: 83590963

Gene position: 2236015-2234786 (Counterclockwise)

Preceding gene: 83590964

Following gene: 83590962

Centisome position: 85.06

GC content: 64.23

Gene sequence:

>1230_bases
ATGGAACTTTTTCAAGTAATAACCCTGGCGGAGGCCCGCAGGCAATTGGGGCGCTACTGGCCCCTACCTGGGCGGCGGGA
GATGGTTGTACCCCTGACGGAAGCCCTGGGACGGGAACTGGTACGACCGGTGGTGGCCGGGGAAGATGTCCCCGGTTTCG
ACCGCGCCACCATGGACGGCTATGCCGTCCGGGCGGTTGATACCTTTAGCGCCCGGGAAGGTGAACCCGTCCTTTTGCGC
CTGGCCGGGGAGGTACCCATGGGGCAAAAAGCCGGAGTCAGGGTTAACCCCGGAGAAGCCGTAGCCGTGGCCACAGGAAG
TATGCTACCGCCCGGGGCGGATGCGGTGGTTATGATCGAAAACACCGAGGTCCTCGAGGACGATCGGGTCGCCGTCTATA
AGCCGGCAGCCCCCGGCCAGGACCTGGTACGGCAGGGATCCGACGTCCGGGCCGGTGCCACCGTCCTCGAGGCCGGCCAT
CGCCTGCGCCCCCAGGACCTGGGCGTACTGGCCAGCCTGGGCATCAACAGGGTTCCGGTATACGAACCCTGGCGGGTGGG
CATCCTGGCCACGGGGAATGAAATCGTCCCCCCGGAGGTCCAGGCTGGTCCCGGCCAGGTGCGGGATATTAATTCCTATA
CCCTTTACGGCCTGGTACGTGATTGCGGTGCTGAAGCCACCCTCTACGGCATCGCCCCCGACGACCTGGAAACCTTGACA
GCCCGGGTCCAGGAAGCCCTGGCGGAAAACCACCTGGTGCTCCTCTCCGGAGGAAGTTCCGTCGGCACCCGGGATTTAAC
CGTGCAGGTCCTGGCTGGCCTGGGACAGCCGGGTATCCTCTTCCACGGCTTAGCCATTCGCCCGGGTAAACCAATCCTGG
CGGCCCTGGCCGGCACAAAGATGGTCTTCGGCCTGCCCGGTCACCCGGTTTCCGCCATGGTGAGCTTTAAGGTCCTCCTC
GAACCCCTGCTACGTTACGGCGGTTATGAGGGCCCGGCCGGCAGGGGGACGGTCACGGCGACCCTGGGCAGTCCAATTCC
TTCTACTCCCGGCCGGGAGGACTATATCCGCGTCCGCCTGGAAGCAGGCCCGGATGGGTTCCTGGCCGTACCGGTACCAG
GAGGTTCGAGTATAATCTCATCCATGATCCAGGCCGACGGCCTGGTAACCATTCCCCTGGAGGAAGAGGGCCTGGAAGCC
GGTACGAAGGTAGAGGTGGAACTCTTTTAG

Upstream 100 bases:

>100_bases
CTTAAGGTACCAATGCGGGAAGTAGGCCGGGCAGCCGATGAGTTGAAGATAAAAATTATCCAGTGTCAGCTGGGGTGTTT
CGAGTAGCAGGGGGAGAGGC

Downstream 100 bases:

>100_bases
GTACTTGATGCCGTTAAAGTTGTTAAATTTTACTTTATGATACAATGGTCCATAAAACGGAGAGAAAGCGGAGAGAAACC
GGAGAGGGTCCGGAAAGTCT

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MELFQVITLAEARRQLGRYWPLPGRREMVVPLTEALGRELVRPVVAGEDVPGFDRATMDGYAVRAVDTFSAREGEPVLLR
LAGEVPMGQKAGVRVNPGEAVAVATGSMLPPGADAVVMIENTEVLEDDRVAVYKPAAPGQDLVRQGSDVRAGATVLEAGH
RLRPQDLGVLASLGINRVPVYEPWRVGILATGNEIVPPEVQAGPGQVRDINSYTLYGLVRDCGAEATLYGIAPDDLETLT
ARVQEALAENHLVLLSGGSSVGTRDLTVQVLAGLGQPGILFHGLAIRPGKPILAALAGTKMVFGLPGHPVSAMVSFKVLL
EPLLRYGGYEGPAGRGTVTATLGSPIPSTPGREDYIRVRLEAGPDGFLAVPVPGGSSIISSMIQADGLVTIPLEEEGLEA
GTKVEVELF

Sequences:

>Translated_409_residues
MELFQVITLAEARRQLGRYWPLPGRREMVVPLTEALGRELVRPVVAGEDVPGFDRATMDGYAVRAVDTFSAREGEPVLLR
LAGEVPMGQKAGVRVNPGEAVAVATGSMLPPGADAVVMIENTEVLEDDRVAVYKPAAPGQDLVRQGSDVRAGATVLEAGH
RLRPQDLGVLASLGINRVPVYEPWRVGILATGNEIVPPEVQAGPGQVRDINSYTLYGLVRDCGAEATLYGIAPDDLETLT
ARVQEALAENHLVLLSGGSSVGTRDLTVQVLAGLGQPGILFHGLAIRPGKPILAALAGTKMVFGLPGHPVSAMVSFKVLL
EPLLRYGGYEGPAGRGTVTATLGSPIPSTPGREDYIRVRLEAGPDGFLAVPVPGGSSIISSMIQADGLVTIPLEEEGLEA
GTKVEVELF
>Mature_409_residues
MELFQVITLAEARRQLGRYWPLPGRREMVVPLTEALGRELVRPVVAGEDVPGFDRATMDGYAVRAVDTFSAREGEPVLLR
LAGEVPMGQKAGVRVNPGEAVAVATGSMLPPGADAVVMIENTEVLEDDRVAVYKPAAPGQDLVRQGSDVRAGATVLEAGH
RLRPQDLGVLASLGINRVPVYEPWRVGILATGNEIVPPEVQAGPGQVRDINSYTLYGLVRDCGAEATLYGIAPDDLETLT
ARVQEALAENHLVLLSGGSSVGTRDLTVQVLAGLGQPGILFHGLAIRPGKPILAALAGTKMVFGLPGHPVSAMVSFKVLL
EPLLRYGGYEGPAGRGTVTATLGSPIPSTPGREDYIRVRLEAGPDGFLAVPVPGGSSIISSMIQADGLVTIPLEEEGLEA
GTKVEVELF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=32.4937027707809, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI66932975, Length=384, Percent_Identity=32.5520833333333, Blast_Score=159, Evalue=7e-39,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=38.7434554973822, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25147659, Length=309, Percent_Identity=32.3624595469256, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=397, Percent_Identity=21.9143576826196, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=28.8515406162465, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=28.8515406162465, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43032; Mature: 43032

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFQVITLAEARRQLGRYWPLPGRREMVVPLTEALGRELVRPVVAGEDVPGFDRATMDG
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YAVRAVDTFSAREGEPVLLRLAGEVPMGQKAGVRVNPGEAVAVATGSMLPPGADAVVMIE
EEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEE
NTEVLEDDRVAVYKPAAPGQDLVRQGSDVRAGATVLEAGHRLRPQDLGVLASLGINRVPV
CCEECCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCC
YEPWRVGILATGNEIVPPEVQAGPGQVRDINSYTLYGLVRDCGAEATLYGIAPDDLETLT
CCCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEHHHHHCCCCEEEEECCCCHHHHHH
ARVQEALAENHLVLLSGGSSVGTRDLTVQVLAGLGQPGILFHGLAIRPGKPILAALAGTK
HHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEECCCE
MVFGLPGHPVSAMVSFKVLLEPLLRYGGYEGPAGRGTVTATLGSPIPSTPGREDYIRVRL
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEE
EAGPDGFLAVPVPGGSSIISSMIQADGLVTIPLEEEGLEAGTKVEVELF
ECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure
MELFQVITLAEARRQLGRYWPLPGRREMVVPLTEALGRELVRPVVAGEDVPGFDRATMDG
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YAVRAVDTFSAREGEPVLLRLAGEVPMGQKAGVRVNPGEAVAVATGSMLPPGADAVVMIE
EEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEE
NTEVLEDDRVAVYKPAAPGQDLVRQGSDVRAGATVLEAGHRLRPQDLGVLASLGINRVPV
CCEECCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCC
YEPWRVGILATGNEIVPPEVQAGPGQVRDINSYTLYGLVRDCGAEATLYGIAPDDLETLT
CCCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEHHHHHCCCCEEEEECCCCHHHHHH
ARVQEALAENHLVLLSGGSSVGTRDLTVQVLAGLGQPGILFHGLAIRPGKPILAALAGTK
HHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEECCCE
MVFGLPGHPVSAMVSFKVLLEPLLRYGGYEGPAGRGTVTATLGSPIPSTPGREDYIRVRL
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEE
EAGPDGFLAVPVPGGSSIISSMIQADGLVTIPLEEEGLEAGTKVEVELF
ECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]