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The map label for this gene is purM

Identifier: 83590876

GI number: 83590876

Start: 2136820

End: 2137872

Strand: Reverse

Name: purM

Synonym: Moth_2046

Alternate gene names: 83590876

Gene position: 2137872-2136820 (Counterclockwise)

Preceding gene: 83590877

Following gene: 83590875

Centisome position: 81.33

GC content: 63.72

Gene sequence:

>1053_bases
ATGGTAGCTGGGGAAGGCTTCACCTATGCTGCCGCCGGCGTGGATATCGCCGCCGGCAACCGCGCCGTCGAATTAATGAA
AGAGCATGTCCGCCGGACCTTCCGGCCGGGGGTGCTGGGGGACCTGGGTGGCTTCGGCGGCCTCTTTGCCCTGGAGGCGG
GGCGTTACCGGCAGCCGGTGCTGGTGGCCGGGACCGACGGGGTGGGGACGAAGCTGAAGATAGCCTTTAGCCTGGACCGG
CACGACACCATCGGCATCGACGCCGTGGCCATGTGCGTCAACGACATCCTGGTCCAGGGGGCCGAACCCCTCTTTTTCCT
GGACTACCTGGCCGTGGGCAAAATGGTGCCGGAAAGGGTGGCCCGGATTGTCGCCGGGGTGGCCGAAGGGTGCCGCCGGG
CTGGTTGCGCCCTCATCGGCGGCGAGACGGCCGAGATGCCCGGCTTTTACCGGGAGGATGAATACGACCTGGCCGGATTT
GCCGTCGGTGTTGTGGAACGGGAGGAGCTTTTGGACGGTAGCCGCATCCGGCCCGGGCAGGTAGTCCTGGGACTGGCATC
CAGTGGCCTGCATTCCAATGGCTTTTCCCTGGCCCGGCGGGTTTTGTTGGTGGAAGCCGGTTATACCCTGGAACGGAAAC
TGCCGGAACTGGGCCGAACCCTGGGAGAAGAACTCCTGGAACCGACGCGGATTTATGTGGCCAGTATTTTACCCTTGCTG
AAAGAAGGACTTATAAAGGGCCTGGCCCACATCACCGGCGGTGGGCTGATTGAGAACCCGCCGCGCATCCTGCCGCCGGG
TTGCAGCCTGCGCCTGGATCGGCGCAGCTGGCCGGTGCCGCCCGCTTTCCGGCTCATCCAGGCTACCGGCAGGGTGCCTG
AGGAAGAAATGTACCGCACCTTCAATATGGGTCTGGGGATGCTGGTGGTGGTTGAGGAAAGCGACGCCGGCAGGGTAAAG
TCCCGGTTGGAGGCCGCAGGCGAGAAGGTTTTTGTCGTTGGTGAGGTTATTCCCGGCCGGCGGGAAGTGGAATTTGTGCC
CGGTTTGCAATAA

Upstream 100 bases:

>100_bases
GCCGCCACCAACGAGGGCATGAAAATGCCTGGTTGGCATTTGTCGGAAGCGAGGGAGACAATGCCAACCGGCGATAGAGT
TATTTTCGGAGGGGGACATT

Downstream 100 bases:

>100_bases
GGGGGAGGAAGGGCTCATGGTTGCGTCAACTTTACCCATTGGCATTCTGGTTTCCGGCCGCGGCAGCAACATGGAGGCCA
TTGCCGCTGCTATAGAGGCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MVAGEGFTYAAAGVDIAAGNRAVELMKEHVRRTFRPGVLGDLGGFGGLFALEAGRYRQPVLVAGTDGVGTKLKIAFSLDR
HDTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKMVPERVARIVAGVAEGCRRAGCALIGGETAEMPGFYREDEYDLAGF
AVGVVEREELLDGSRIRPGQVVLGLASSGLHSNGFSLARRVLLVEAGYTLERKLPELGRTLGEELLEPTRIYVASILPLL
KEGLIKGLAHITGGGLIENPPRILPPGCSLRLDRRSWPVPPAFRLIQATGRVPEEEMYRTFNMGLGMLVVVEESDAGRVK
SRLEAAGEKVFVVGEVIPGRREVEFVPGLQ

Sequences:

>Translated_350_residues
MVAGEGFTYAAAGVDIAAGNRAVELMKEHVRRTFRPGVLGDLGGFGGLFALEAGRYRQPVLVAGTDGVGTKLKIAFSLDR
HDTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKMVPERVARIVAGVAEGCRRAGCALIGGETAEMPGFYREDEYDLAGF
AVGVVEREELLDGSRIRPGQVVLGLASSGLHSNGFSLARRVLLVEAGYTLERKLPELGRTLGEELLEPTRIYVASILPLL
KEGLIKGLAHITGGGLIENPPRILPPGCSLRLDRRSWPVPPAFRLIQATGRVPEEEMYRTFNMGLGMLVVVEESDAGRVK
SRLEAAGEKVFVVGEVIPGRREVEFVPGLQ
>Mature_350_residues
MVAGEGFTYAAAGVDIAAGNRAVELMKEHVRRTFRPGVLGDLGGFGGLFALEAGRYRQPVLVAGTDGVGTKLKIAFSLDR
HDTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKMVPERVARIVAGVAEGCRRAGCALIGGETAEMPGFYREDEYDLAGF
AVGVVEREELLDGSRIRPGQVVLGLASSGLHSNGFSLARRVLLVEAGYTLERKLPELGRTLGEELLEPTRIYVASILPLL
KEGLIKGLAHITGGGLIENPPRILPPGCSLRLDRRSWPVPPAFRLIQATGRVPEEEMYRTFNMGLGMLVVVEESDAGRVK
SRLEAAGEKVFVVGEVIPGRREVEFVPGLQ

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=51.4880952380952, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=51.4880952380952, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=51.4880952380952, Blast_Score=336, Evalue=2e-92,
Organism=Escherichia coli, GI1788845, Length=335, Percent_Identity=50.7462686567164, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=44.213649851632, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=48.3582089552239, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24582400, Length=288, Percent_Identity=47.2222222222222, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_MOOTA (Q2RGU7)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430885.1
- ProteinModelPortal:   Q2RGU7
- SMR:   Q2RGU7
- STRING:   Q2RGU7
- GeneID:   3831192
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2046
- NMPDR:   fig|264732.9.peg.2068
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   Q2RGU7
- ProtClustDB:   PRK05385
- BioCyc:   MTHE264732:MOTH_2046-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37591; Mature: 37591

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGEGFTYAAAGVDIAAGNRAVELMKEHVRRTFRPGVLGDLGGFGGLFALEAGRYRQPV
CCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCE
LVAGTDGVGTKLKIAFSLDRHDTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKMVPERV
EEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ARIVAGVAEGCRRAGCALIGGETAEMPGFYREDEYDLAGFAVGVVEREELLDGSRIRPGQ
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCCCCCC
VVLGLASSGLHSNGFSLARRVLLVEAGYTLERKLPELGRTLGEELLEPTRIYVASILPLL
EEEEEECCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KEGLIKGLAHITGGGLIENPPRILPPGCSLRLDRRSWPVPPAFRLIQATGRVPEEEMYRT
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCHHHHHHH
FNMGLGMLVVVEESDAGRVKSRLEAAGEKVFVVGEVIPGRREVEFVPGLQ
HHCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVAGEGFTYAAAGVDIAAGNRAVELMKEHVRRTFRPGVLGDLGGFGGLFALEAGRYRQPV
CCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCE
LVAGTDGVGTKLKIAFSLDRHDTIGIDAVAMCVNDILVQGAEPLFFLDYLAVGKMVPERV
EEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ARIVAGVAEGCRRAGCALIGGETAEMPGFYREDEYDLAGFAVGVVEREELLDGSRIRPGQ
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCCCCCC
VVLGLASSGLHSNGFSLARRVLLVEAGYTLERKLPELGRTLGEELLEPTRIYVASILPLL
EEEEEECCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KEGLIKGLAHITGGGLIENPPRILPPGCSLRLDRRSWPVPPAFRLIQATGRVPEEEMYRT
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCHHHHHHH
FNMGLGMLVVVEESDAGRVKSRLEAAGEKVFVVGEVIPGRREVEFVPGLQ
HHCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA