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The map label for this gene is purN [H]

Identifier: 83590875

GI number: 83590875

Start: 2136186

End: 2136803

Strand: Reverse

Name: purN [H]

Synonym: Moth_2045

Alternate gene names: 83590875

Gene position: 2136803-2136186 (Counterclockwise)

Preceding gene: 83590876

Following gene: 83590874

Centisome position: 81.28

GC content: 64.56

Gene sequence:

>618_bases
ATGGTTGCGTCAACTTTACCCATTGGCATTCTGGTTTCCGGCCGCGGCAGCAACATGGAGGCCATTGCCGCTGCTATAGA
GGCTGGGGAGGTGCCGGCCCGCATCCAGGCGGTCATAAGCGACCGGCCGGAGGCCCGCGCCCTGGAGCTGGCCCGGGAAC
GGGGGTTGAAAGCCTTCTGCCTCGCGCCCGGGGAATATCCTTCACGGCAGGCCTATGACCTGGCCCTGGCGACGGCCCTG
AAAAAAGAGGGGGTGGAACTGGTAGCCCTGGCCGGTTTTATGCGCCTCCTGGGCCGGGAGTTTCTGGAACAGTTCCCGGG
AGCGGTCATCAACATCCACCCGGCCCTGTTGCCTGCTTTCCCGGGGCTTAACGCCCAGCGTCAGGCCCTGGAGTACGGCG
TCAAGTTTTCCGGCTGCACCGTCCACTTTGTCGACGCCGGCATGGACACCGGCCCCATCATCGCCCAGGCCGTAGTACCG
GTCCGGAACGATGATACCCCGGAAACCCTGGCCGCCCGCATCCTGGCGGAGGAGCATCGCCTCTACCCCCGGGTGATCAA
GTGGTTGGCCGAAGGCCGGGTAGAACTCCGGGGCCGGCGGGTAATAGTAAGAATTTGA

Upstream 100 bases:

>100_bases
GAGGCCGCAGGCGAGAAGGTTTTTGTCGTTGGTGAGGTTATTCCCGGCCGGCGGGAAGTGGAATTTGTGCCCGGTTTGCA
ATAAGGGGGAGGAAGGGCTC

Downstream 100 bases:

>100_bases
AGGAGCCGCTCTACCATCGAACAGGAAAATTTGATGTTACGCCATGGTGGTGCGTCGATTTTATCCGGCCCAAGGCCTGC
GGAGCGAAGGCCTTGGAATT

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MVASTLPIGILVSGRGSNMEAIAAAIEAGEVPARIQAVISDRPEARALELARERGLKAFCLAPGEYPSRQAYDLALATAL
KKEGVELVALAGFMRLLGREFLEQFPGAVINIHPALLPAFPGLNAQRQALEYGVKFSGCTVHFVDAGMDTGPIIAQAVVP
VRNDDTPETLAARILAEEHRLYPRVIKWLAEGRVELRGRRVIVRI

Sequences:

>Translated_205_residues
MVASTLPIGILVSGRGSNMEAIAAAIEAGEVPARIQAVISDRPEARALELARERGLKAFCLAPGEYPSRQAYDLALATAL
KKEGVELVALAGFMRLLGREFLEQFPGAVINIHPALLPAFPGLNAQRQALEYGVKFSGCTVHFVDAGMDTGPIIAQAVVP
VRNDDTPETLAARILAEEHRLYPRVIKWLAEGRVELRGRRVIVRI
>Mature_205_residues
MVASTLPIGILVSGRGSNMEAIAAAIEAGEVPARIQAVISDRPEARALELARERGLKAFCLAPGEYPSRQAYDLALATAL
KKEGVELVALAGFMRLLGREFLEQFPGAVINIHPALLPAFPGLNAQRQALEYGVKFSGCTVHFVDAGMDTGPIIAQAVVP
VRNDDTPETLAARILAEEHRLYPRVIKWLAEGRVELRGRRVIVRI

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=189, Percent_Identity=39.1534391534392, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI209869995, Length=189, Percent_Identity=39.1534391534392, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI209869993, Length=189, Percent_Identity=39.1534391534392, Blast_Score=150, Evalue=9e-37,
Organism=Escherichia coli, GI1788846, Length=192, Percent_Identity=41.1458333333333, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1787483, Length=196, Percent_Identity=33.6734693877551, Blast_Score=97, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17567511, Length=179, Percent_Identity=39.6648044692737, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320616, Length=195, Percent_Identity=27.6923076923077, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24582400, Length=187, Percent_Identity=43.3155080213904, Blast_Score=160, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 22186; Mature: 22186

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVASTLPIGILVSGRGSNMEAIAAAIEAGEVPARIQAVISDRPEARALELARERGLKAFC
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEE
LAPGEYPSRQAYDLALATALKKEGVELVALAGFMRLLGREFLEQFPGAVINIHPALLPAF
ECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCC
PGLNAQRQALEYGVKFSGCTVHFVDAGMDTGPIIAQAVVPVRNDDTPETLAARILAEEHR
CCCCHHHHHHHHCCEECCCEEEEEECCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHH
LYPRVIKWLAEGRVELRGRRVIVRI
HHHHHHHHHHCCCEEECCCEEEEEC
>Mature Secondary Structure
MVASTLPIGILVSGRGSNMEAIAAAIEAGEVPARIQAVISDRPEARALELARERGLKAFC
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEE
LAPGEYPSRQAYDLALATALKKEGVELVALAGFMRLLGREFLEQFPGAVINIHPALLPAF
ECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCC
PGLNAQRQALEYGVKFSGCTVHFVDAGMDTGPIIAQAVVPVRNDDTPETLAARILAEEHR
CCCCHHHHHHHHCCEECCCEEEEEECCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHH
LYPRVIKWLAEGRVELRGRRVIVRI
HHHHHHHHHHCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301838; 9205837; 9278503; 10954745; 2204419; 1522592; 1631098; 9698564; 10606510 [H]