Click here to switch to the map view.

The map label for this gene is purH

Identifier: 83590874

GI number: 83590874

Start: 2134455

End: 2135996

Strand: Reverse

Name: purH

Synonym: Moth_2044

Alternate gene names: 83590874

Gene position: 2135996-2134455 (Counterclockwise)

Preceding gene: 83590875

Following gene: 83590873

Centisome position: 81.25

GC content: 65.37

Gene sequence:

>1542_bases
ATGTCTAAAAGGGCTCTAATCAGCGTCTCCGACAAAACCGGTCTGGTGGAACTGGCCCGCGGCCTGGTGGAACTGGGCTG
GGAACTCCTTTCCACCGGCGGCACGGCCCGCACCTTAATCGCAGCCGGCCTGCCTGTGACCGAAGTGGCAGCCGTCACCG
GCTTTCCCGAGATCCTTGACGGCCGGGTCAAGACCCTGCACCCGAAGATCCACGGCGGCATCCTGGCCCGGCCGACCCCC
GAACACCTGGCCCAGCTCCAGGAGCAGGGCATCCAGCCCATCGACCTGGTGGTGGTCAACCTCTACCCCTTCCGGGAAAC
TATCGCCCGGCCCGGAGTGACGCCGGCGGAGGCCATTGAAAACATCGACATCGGCGGCCCGGCCATGGTCAGGGCGGCGG
CCAAGAACCACGAGAGGGTGGGTATTGTCGTCGACCCGGCCAGTTACAATGAGGTGTTAACGGAACTGAGGGAGAAAGGA
AGCTTGAGCCCGGAGACCAGGCGCCGCCTGGCGGCGGCGGCCTTCGCCCATACCGCCGCCTACGACGCGGCCATTGCGGC
CTATTTCCAGCGCCTCATGCGCAATGAAGAACCCTTCCCGGCCAGCTTCGTCTTAAGCGGTGAAAAGGTCCAGGACCTGC
GCTACGGCGAGAACCCCCACCAGGGGGCCGCTTTCTACCGCTTGCCCGCCCCACCCCCCGGCACCCTGGCCGGGGCCCGG
CAGCTCCAGGGCAAGGAGCTTTCATATAATAACCTCATGGACCTGGACGCCGCCTGGAACCTGGCCTGTGACTTCAAAGA
ACCGGTGGTGGCGATCATCAAACATACCAACCCCTGCGGGGTCGCCCGGGCAAGTACCCCGGCTGCGGCCTACCGCCTGG
CTTACGCTGCCGACCCCGTTTCCGCCTTTGGCGGCATCGTCGCCTGCAACCGGCCGGTGGACGGCGAAATGGCCGGGGCC
ATGACGGAGATATTCCTGGAAGCAGTCATCGCCCCGTCTTTTACCCCGGAAGCCATGGCGATCCTGAAAAGCAAATCCAA
CCTGCGCCTTCTGGCCGCGGGTGAGAGGGCGGGTTGCCGTACCCGGGAATACCAGATAAGGCCCGTCAGCGGCGGCTTCC
TGGTCCAGGAGCCGGACTACCATGTCCTCGAGCCGGAGAGCCTCAAGGTGGTAACCGCCCGTAAACCTGAAGCCAAAGAG
ATGGCCGACCTGCTCTTCGCCTGGCAGGTAGTCAAACACGTCAAGTCCAACGCCATCGTGGTGGCCAGGGACGGCGTCAC
CCTGGGTATCGGCGCCGGCCAGATGAACCGGGTGGGGGCGGCTCGCATCGCCCTGGAGCAGGCCGGGGCCCGGGCTAAAG
GCGCCGTTCTGGCTTCCGACGCCTTCTTCCCCTTCGGCGACACCGTGGAACTGGCGGCCGGGGCCGGGATCACAGCCATC
ATCCAGCCCGGCGGCTCTATCCGCGACGAGGAGTCGATCAGGGCTGCCGATGCCGCGGGTATAGCCATGGTTTTCACCGG
CATCCGCCACTTCCGGCATTAA

Upstream 100 bases:

>100_bases
GCCTTGGAATTGGGCGCAACCAGCGCTTGAGGGGAACCTTTAGTGGCATGGTAGAGTTAGGGATGTTTCAGCAATTGAAA
GGGAGGCAGGTTTAAAACAT

Downstream 100 bases:

>100_bases
AGGAGGGCACTGGAAGATGCGTATCCTGGTAGTTGGCGGCGGCGGCCGGGAACACGCCCTGGTCTGGAAGATTGCCCGGA
GTCCCAGGGTTACGGAAATC

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSKRALISVSDKTGLVELARGLVELGWELLSTGGTARTLIAAGLPVTEVAAVTGFPEILDGRVKTLHPKIHGGILARPTP
EHLAQLQEQGIQPIDLVVVNLYPFRETIARPGVTPAEAIENIDIGGPAMVRAAAKNHERVGIVVDPASYNEVLTELREKG
SLSPETRRRLAAAAFAHTAAYDAAIAAYFQRLMRNEEPFPASFVLSGEKVQDLRYGENPHQGAAFYRLPAPPPGTLAGAR
QLQGKELSYNNLMDLDAAWNLACDFKEPVVAIIKHTNPCGVARASTPAAAYRLAYAADPVSAFGGIVACNRPVDGEMAGA
MTEIFLEAVIAPSFTPEAMAILKSKSNLRLLAAGERAGCRTREYQIRPVSGGFLVQEPDYHVLEPESLKVVTARKPEAKE
MADLLFAWQVVKHVKSNAIVVARDGVTLGIGAGQMNRVGAARIALEQAGARAKGAVLASDAFFPFGDTVELAAGAGITAI
IQPGGSIRDEESIRAADAAGIAMVFTGIRHFRH

Sequences:

>Translated_513_residues
MSKRALISVSDKTGLVELARGLVELGWELLSTGGTARTLIAAGLPVTEVAAVTGFPEILDGRVKTLHPKIHGGILARPTP
EHLAQLQEQGIQPIDLVVVNLYPFRETIARPGVTPAEAIENIDIGGPAMVRAAAKNHERVGIVVDPASYNEVLTELREKG
SLSPETRRRLAAAAFAHTAAYDAAIAAYFQRLMRNEEPFPASFVLSGEKVQDLRYGENPHQGAAFYRLPAPPPGTLAGAR
QLQGKELSYNNLMDLDAAWNLACDFKEPVVAIIKHTNPCGVARASTPAAAYRLAYAADPVSAFGGIVACNRPVDGEMAGA
MTEIFLEAVIAPSFTPEAMAILKSKSNLRLLAAGERAGCRTREYQIRPVSGGFLVQEPDYHVLEPESLKVVTARKPEAKE
MADLLFAWQVVKHVKSNAIVVARDGVTLGIGAGQMNRVGAARIALEQAGARAKGAVLASDAFFPFGDTVELAAGAGITAI
IQPGGSIRDEESIRAADAAGIAMVFTGIRHFRH
>Mature_512_residues
SKRALISVSDKTGLVELARGLVELGWELLSTGGTARTLIAAGLPVTEVAAVTGFPEILDGRVKTLHPKIHGGILARPTPE
HLAQLQEQGIQPIDLVVVNLYPFRETIARPGVTPAEAIENIDIGGPAMVRAAAKNHERVGIVVDPASYNEVLTELREKGS
LSPETRRRLAAAAFAHTAAYDAAIAAYFQRLMRNEEPFPASFVLSGEKVQDLRYGENPHQGAAFYRLPAPPPGTLAGARQ
LQGKELSYNNLMDLDAAWNLACDFKEPVVAIIKHTNPCGVARASTPAAAYRLAYAADPVSAFGGIVACNRPVDGEMAGAM
TEIFLEAVIAPSFTPEAMAILKSKSNLRLLAAGERAGCRTREYQIRPVSGGFLVQEPDYHVLEPESLKVVTARKPEAKEM
ADLLFAWQVVKHVKSNAIVVARDGVTLGIGAGQMNRVGAARIALEQAGARAKGAVLASDAFFPFGDTVELAAGAGITAII
QPGGSIRDEESIRAADAAGIAMVFTGIRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=475, Percent_Identity=40, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1790439, Length=524, Percent_Identity=53.0534351145038, Blast_Score=519, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=36.2869198312236, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71985574, Length=305, Percent_Identity=27.8688524590164, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=38.2352941176471, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6323056, Length=472, Percent_Identity=37.2881355932203, Blast_Score=283, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24649832, Length=474, Percent_Identity=39.4514767932489, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_MOOTA (Q2RGU9)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430883.1
- HSSP:   P31335
- ProteinModelPortal:   Q2RGU9
- SMR:   Q2RGU9
- STRING:   Q2RGU9
- GeneID:   3831190
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2044
- NMPDR:   fig|264732.9.peg.2066
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q2RGU9
- BioCyc:   MTHE264732:MOTH_2044-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 54593; Mature: 54462

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRALISVSDKTGLVELARGLVELGWELLSTGGTARTLIAAGLPVTEVAAVTGFPEILD
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCHHHHC
GRVKTLHPKIHGGILARPTPEHLAQLQEQGIQPIDLVVVNLYPFRETIARPGVTPAEAIE
CCCEEECHHHCCCEECCCCHHHHHHHHHCCCCEEEEEEEEEECHHHHHHCCCCCHHHHHH
NIDIGGPAMVRAAAKNHERVGIVVDPASYNEVLTELREKGSLSPETRRRLAAAAFAHTAA
CCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YDAAIAAYFQRLMRNEEPFPASFVLSGEKVQDLRYGENPHQGAAFYRLPAPPPGTLAGAR
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHH
QLQGKELSYNNLMDLDAAWNLACDFKEPVVAIIKHTNPCGVARASTPAAAYRLAYAADPV
HCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHEEHHHCCCH
SAFGGIVACNRPVDGEMAGAMTEIFLEAVIAPSFTPEAMAILKSKSNLRLLAAGERAGCR
HHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
TREYQIRPVSGGFLVQEPDYHVLEPESLKVVTARKPEAKEMADLLFAWQVVKHVKSNAIV
CCCEEEEECCCCEEEECCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VARDGVTLGIGAGQMNRVGAARIALEQAGARAKGAVLASDAFFPFGDTVELAAGAGITAI
EEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEECCCCCEEEE
IQPGGSIRDEESIRAADAAGIAMVFTGIRHFRH
ECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKRALISVSDKTGLVELARGLVELGWELLSTGGTARTLIAAGLPVTEVAAVTGFPEILD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCHHHHC
GRVKTLHPKIHGGILARPTPEHLAQLQEQGIQPIDLVVVNLYPFRETIARPGVTPAEAIE
CCCEEECHHHCCCEECCCCHHHHHHHHHCCCCEEEEEEEEEECHHHHHHCCCCCHHHHHH
NIDIGGPAMVRAAAKNHERVGIVVDPASYNEVLTELREKGSLSPETRRRLAAAAFAHTAA
CCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YDAAIAAYFQRLMRNEEPFPASFVLSGEKVQDLRYGENPHQGAAFYRLPAPPPGTLAGAR
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHH
QLQGKELSYNNLMDLDAAWNLACDFKEPVVAIIKHTNPCGVARASTPAAAYRLAYAADPV
HCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHEEHHHCCCH
SAFGGIVACNRPVDGEMAGAMTEIFLEAVIAPSFTPEAMAILKSKSNLRLLAAGERAGCR
HHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
TREYQIRPVSGGFLVQEPDYHVLEPESLKVVTARKPEAKEMADLLFAWQVVKHVKSNAIV
CCCEEEEECCCCEEEECCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VARDGVTLGIGAGQMNRVGAARIALEQAGARAKGAVLASDAFFPFGDTVELAAGAGITAI
EEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEECCCCCEEEE
IQPGGSIRDEESIRAADAAGIAMVFTGIRHFRH
ECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA