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The map label for this gene is purD [H]

Identifier: 83590873

GI number: 83590873

Start: 2133173

End: 2134438

Strand: Reverse

Name: purD [H]

Synonym: Moth_2043

Alternate gene names: 83590873

Gene position: 2134438-2133173 (Counterclockwise)

Preceding gene: 83590874

Following gene: 83590872

Centisome position: 81.19

GC content: 65.72

Gene sequence:

>1266_bases
ATGCGTATCCTGGTAGTTGGCGGCGGCGGCCGGGAACACGCCCTGGTCTGGAAGATTGCCCGGAGTCCCAGGGTTACGGA
AATCTACTGCGCCCCGGGCAACGCCGGCATCGCCGGCCTGGCCTACTGTGTGCCCATTGCTGCCGATGATATTACCGGCC
TGCTGGACTTCGCCCGTCGGGCTGCCATAGATCTCACCGTCGTCGGTCCCGAGGCCCCCCTGGTGGCCGGTATCGTCGAC
GCCTTCCAGGCGGCCGGCCTGCCAATCTTTGGCCCCTCCCGGGGAGCGGCCCGGCTGGAAGGAAGCAAGATTTTCGCCAA
AGAGTTGATGCAGGAAGCAGGCATCCCCACGGCTGCCCACGCTACCTTTACGGAGCCCGGTCCGGCCCTGGCCTACCTGG
AGGAACACCCCGGACCGGTGGTGGTCAAGGCCGACGGCCTGGCAGCCGGCAAGGGCGTGGTGGTGGCCCCGGACGCGGCT
ACGGCCCGAGCAGCGGTCCGGGATATGTTTGGAGGCAAATTTGGTCCCGCCGGCCGGAGGGTAATCCTCGAAGAACGCCT
GGAAGGGGAAGAAGTCAGCATCCTGGCCCTGTGCGATGGGAAAACAGCTATTCCCCTCCTCCCTTCCCAGGACCATAAGC
GGGTGGGGGAAGGGGATACCGGCCCCAATACCGGCGGCATGGGCGCCTACGCGCCGGTGCCCTTCTATACCCCGGAGATT
GCCGCCCAGGTGGAAGAAAGGGTTCTCCGGCCGGTTATCCGGACCATGGCCGCAGCCGGGCACCCCTACCGGGGCGTCCT
TTACGCCGGGCTGATGCTTACCCGGGAAGGTCCCAAAGTCCTGGAGTTCAACTGTCGCTTCGGCGACCCGGAAACCCAGC
CCCTGATGCTCCTTTTGGCAAGCGACCTGGTGGAGCTGATGCTAGCTGCCGTCAACGGTGAGCTGGCGGGAACGAGGATC
GCCTGGTACCCCGGTGCCGCCGCCGGGGTGGTCCTGGCGGCGGGCGGTTATCCGGGCCCGTACGCCAAGGGTGATTTTAT
TACGGGATTGGAGGCAGTGGCACCGGGGGTGGAAGTCTTCCACGCCGGCACCGCCCTGGTGGACGGCCAGGTCGTAACGT
CCGGGGGCCGGGTGGTGTGTGTAACCGCCCGGGGTAAAGATTTACGGGCCGCTTTGGACCGCGTTTATGACAGTATCAGG
GCCATCCACTTCCAGGGAATGCACTACCGCCGGGATATCGGCCGTCGGGCCTTGGAGGCAACTTAA

Upstream 100 bases:

>100_bases
ATCCGCGACGAGGAGTCGATCAGGGCTGCCGATGCCGCGGGTATAGCCATGGTTTTCACCGGCATCCGCCACTTCCGGCA
TTAAAGGAGGGCACTGGAAG

Downstream 100 bases:

>100_bases
ATAATTTAAATTTAAGATAAAAGCCCCTTTCGGCAGAAAGCGAAAGGGGCTTTTACGAAAAGTCATTTTCGAGCCCCCCT
GCTCTTCCCCGGGCGCATAA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRILVVGGGGREHALVWKIARSPRVTEIYCAPGNAGIAGLAYCVPIAADDITGLLDFARRAAIDLTVVGPEAPLVAGIVD
AFQAAGLPIFGPSRGAARLEGSKIFAKELMQEAGIPTAAHATFTEPGPALAYLEEHPGPVVVKADGLAAGKGVVVAPDAA
TARAAVRDMFGGKFGPAGRRVILEERLEGEEVSILALCDGKTAIPLLPSQDHKRVGEGDTGPNTGGMGAYAPVPFYTPEI
AAQVEERVLRPVIRTMAAAGHPYRGVLYAGLMLTREGPKVLEFNCRFGDPETQPLMLLLASDLVELMLAAVNGELAGTRI
AWYPGAAAGVVLAAGGYPGPYAKGDFITGLEAVAPGVEVFHAGTALVDGQVVTSGGRVVCVTARGKDLRAALDRVYDSIR
AIHFQGMHYRRDIGRRALEAT

Sequences:

>Translated_421_residues
MRILVVGGGGREHALVWKIARSPRVTEIYCAPGNAGIAGLAYCVPIAADDITGLLDFARRAAIDLTVVGPEAPLVAGIVD
AFQAAGLPIFGPSRGAARLEGSKIFAKELMQEAGIPTAAHATFTEPGPALAYLEEHPGPVVVKADGLAAGKGVVVAPDAA
TARAAVRDMFGGKFGPAGRRVILEERLEGEEVSILALCDGKTAIPLLPSQDHKRVGEGDTGPNTGGMGAYAPVPFYTPEI
AAQVEERVLRPVIRTMAAAGHPYRGVLYAGLMLTREGPKVLEFNCRFGDPETQPLMLLLASDLVELMLAAVNGELAGTRI
AWYPGAAAGVVLAAGGYPGPYAKGDFITGLEAVAPGVEVFHAGTALVDGQVVTSGGRVVCVTARGKDLRAALDRVYDSIR
AIHFQGMHYRRDIGRRALEAT
>Mature_421_residues
MRILVVGGGGREHALVWKIARSPRVTEIYCAPGNAGIAGLAYCVPIAADDITGLLDFARRAAIDLTVVGPEAPLVAGIVD
AFQAAGLPIFGPSRGAARLEGSKIFAKELMQEAGIPTAAHATFTEPGPALAYLEEHPGPVVVKADGLAAGKGVVVAPDAA
TARAAVRDMFGGKFGPAGRRVILEERLEGEEVSILALCDGKTAIPLLPSQDHKRVGEGDTGPNTGGMGAYAPVPFYTPEI
AAQVEERVLRPVIRTMAAAGHPYRGVLYAGLMLTREGPKVLEFNCRFGDPETQPLMLLLASDLVELMLAAVNGELAGTRI
AWYPGAAAGVVLAAGGYPGPYAKGDFITGLEAVAPGVEVFHAGTALVDGQVVTSGGRVVCVTARGKDLRAALDRVYDSIR
AIHFQGMHYRRDIGRRALEAT

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=423, Percent_Identity=50.1182033096927, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI209869995, Length=423, Percent_Identity=50.1182033096927, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI209869993, Length=423, Percent_Identity=50.1182033096927, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI28416899, Length=423, Percent_Identity=50.1182033096927, Blast_Score=393, Evalue=1e-109,
Organism=Escherichia coli, GI1790438, Length=426, Percent_Identity=56.3380281690141, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17567511, Length=420, Percent_Identity=43.8095238095238, Blast_Score=327, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6321203, Length=442, Percent_Identity=43.2126696832579, Blast_Score=353, Evalue=2e-98,
Organism=Drosophila melanogaster, GI62471619, Length=430, Percent_Identity=46.046511627907, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24582400, Length=430, Percent_Identity=46.046511627907, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 43898; Mature: 43898

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGGGGREHALVWKIARSPRVTEIYCAPGNAGIAGLAYCVPIAADDITGLLDFARR
CEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHEECCHHHHHHHHHHHHH
AAIDLTVVGPEAPLVAGIVDAFQAAGLPIFGPSRGAARLEGSKIFAKELMQEAGIPTAAH
HEEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
ATFTEPGPALAYLEEHPGPVVVKADGLAAGKGVVVAPDAATARAAVRDMFGGKFGPAGRR
CEECCCCCEEEEEECCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCE
VILEERLEGEEVSILALCDGKTAIPLLPSQDHKRVGEGDTGPNTGGMGAYAPVPFYTPEI
EEEHHHCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
AAQVEERVLRPVIRTMAAAGHPYRGVLYAGLMLTREGPKVLEFNCRFGDPETQPLMLLLA
HHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
SDLVELMLAAVNGELAGTRIAWYPGAAAGVVLAAGGYPGPYAKGDFITGLEAVAPGVEVF
HHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCHHCCHHHHCCCHHEE
HAGTALVDGQVVTSGGRVVCVTARGKDLRAALDRVYDSIRAIHFQGMHYRRDIGRRALEA
ECCCEEECCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
T
C
>Mature Secondary Structure
MRILVVGGGGREHALVWKIARSPRVTEIYCAPGNAGIAGLAYCVPIAADDITGLLDFARR
CEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHEECCHHHHHHHHHHHHH
AAIDLTVVGPEAPLVAGIVDAFQAAGLPIFGPSRGAARLEGSKIFAKELMQEAGIPTAAH
HEEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
ATFTEPGPALAYLEEHPGPVVVKADGLAAGKGVVVAPDAATARAAVRDMFGGKFGPAGRR
CEECCCCCEEEEEECCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCE
VILEERLEGEEVSILALCDGKTAIPLLPSQDHKRVGEGDTGPNTGGMGAYAPVPFYTPEI
EEEHHHCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
AAQVEERVLRPVIRTMAAAGHPYRGVLYAGLMLTREGPKVLEFNCRFGDPETQPLMLLLA
HHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
SDLVELMLAAVNGELAGTRIAWYPGAAAGVVLAAGGYPGPYAKGDFITGLEAVAPGVEVF
HHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCHHCCHHHHCCCHHEE
HAGTALVDGQVVTSGGRVVCVTARGKDLRAALDRVYDSIRAIHFQGMHYRRDIGRRALEA
ECCCEEECCEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]