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The map label for this gene is hisD

Identifier: 83590865

GI number: 83590865

Start: 2124247

End: 2125521

Strand: Reverse

Name: hisD

Synonym: Moth_2035

Alternate gene names: 83590865

Gene position: 2125521-2124247 (Counterclockwise)

Preceding gene: 83590866

Following gene: 83590864

Centisome position: 80.86

GC content: 65.65

Gene sequence:

>1275_bases
TTGCTACCACTAATTGATGGTAAAGAGGTAAAGCGCCGCTGGTCCGGGCGTCTCCTGGCCCGGGAAGGGGTGGCAGCCAG
GGTGCGGGAGATTATTGCCGCCGTGAAGAGGGAAGGCCAGGCTGCGGTGGAGCGCTATACCCTGGAACTGGACGGTGTCG
ACCTTAAGGAGGCTGGCTTCCGGGTAACCAGAGAAGAGATTGGGGCCGCTTACAGGGCCGTTAGCCCGGACCTTCTGGAA
GCCCTGAGGATCGCCAGGGACAATATCGCCACTTATCACCGCCGCCAACCCCGCGGTTCCTGGATGGAGACGGCAGCGGA
CGGCACCATCCTGGGCCAGATCTGCCGGCCCCTGGGACGGGTGGGGCTTTATGTGCCAGGTGGCACGGCGGCTTACCCTT
CGTCGGTATTGATGACCGCTGTACCGGCCCGGGTGGCCGGGGTCAGGGAGATTGCCCTAGCGACACCGCCGCGGCGGGAC
GGGACACTACCGCCCCTGCTCTTGGTGGCGGCAGCGGAAGCCGGAGTAGAAGAGATCTACAAAATGGGGGGCGCCCAGGC
CGTGGCCGCCCTGGCCTACGGTACGGAGAAAGTGGCCCCGGTGGATAAGATCGCCGGGCCGGGGAATATCTACGTTACCC
TGGCGAAGAAGGAAGTCTACGGCCAGGTGGATATCGACATGCTGGCCGGGCCCAGTGAGATTGTCGTGATCGCCGATGGA
AAGGCCCGGCCGGACTGGGTGGCGGCCGACCTTCTCTCCCAGGCCGAACACGACGCCCTGGCCGGGGCAGTCCTCATCAC
GCCGGATGCCGGCCTGGCCCGGGCGGTGGGGGAGGAAGTTACCCGCCAGCTCGAAGCCTTGCCCAGGCGGGAGATTGCCA
GCCGTTCCCTGGCCGATTACGGCGCCGCCGTAGTGGTGACGGGCCTGGACGCTGCCATGGACCTGGCCAACTCCCTGGCC
CCGGAGCACCTGGAGCTGTACGTATCTGAACCCTGGTCATGGCTGGGCCGGGTGGAGAATGCCGGGGCGATTTTCCTGGG
GCCTTATAGTTCCGAGCCCCTGGGCGATTACCTGGCCGGTCCCAGCCACGTCCTACCCACCGGCGGCACGGCCAGGTTCT
ATTCACCCCTGAGCGTAGACACCTTTTTAAAGAAAAGTAGCTTGATTGCCTGCAACCGGGCGGGCTTCCGGGCTGCCGCG
GGATATATCCAGGCTCTGGCCCGGGCCGAGGGCCTGGAGGGGCACGCCCGGGCCATCGAGCTACGGGAGGAATGA

Upstream 100 bases:

>100_bases
CGCCTGATAGCCAACCGGGTCAGCTACCGCATAAATTACCGCCGCCTGACATCGGTGGTGGAAGCCCTGAAGCGGGCGGC
CGGCCAGGGGGGAGAAAAGA

Downstream 100 bases:

>100_bases
CCCGTCATGAGTCGCGAGGCCCTGATTGAGCGCCAGACCACGGAAACAAACATTCGCTTGAAGGTTGCCCTGGACGGGAG
CGGTACCTGGCAGGGGAGCA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGFRVTREEIGAAYRAVSPDLLE
ALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGRVGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRD
GTLPPLLLVAAAEAGVEEIYKMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADG
KARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADYGAAVVVTGLDAAMDLANSLA
PEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAGPSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAA
GYIQALARAEGLEGHARAIELREE

Sequences:

>Translated_424_residues
MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGFRVTREEIGAAYRAVSPDLLE
ALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGRVGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRD
GTLPPLLLVAAAEAGVEEIYKMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADG
KARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADYGAAVVVTGLDAAMDLANSLA
PEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAGPSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAA
GYIQALARAEGLEGHARAIELREE
>Mature_424_residues
MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGFRVTREEIGAAYRAVSPDLLE
ALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGRVGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRD
GTLPPLLLVAAAEAGVEEIYKMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADG
KARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADYGAAVVVTGLDAAMDLANSLA
PEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAGPSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAA
GYIQALARAEGLEGHARAIELREE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=428, Percent_Identity=39.7196261682243, Blast_Score=287, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=405, Percent_Identity=38.5185185185185, Blast_Score=265, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_MOOTA (Q2RGV8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430874.1
- ProteinModelPortal:   Q2RGV8
- SMR:   Q2RGV8
- STRING:   Q2RGV8
- GeneID:   3831410
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2035
- NMPDR:   fig|264732.9.peg.2056
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- PhylomeDB:   Q2RGV8
- BioCyc:   MTHE264732:MOTH_2035-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45045; Mature: 45045

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 322-322 ACT_SITE 323-323 BINDING 124-124 BINDING 186-186 BINDING 209-209 BINDING 232-232 BINDING 254-254 BINDING 257-257 BINDING 323-323 BINDING 356-356 BINDING 410-410 BINDING 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGF
CCCCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHEEEEECCCCHHHHCC
RVTREEIGAAYRAVSPDLLEALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGR
EEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHH
VGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRDGTLPPLLLVAAAEAGVEEIY
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADG
HCCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEECHHCCCCCEEEECCCCEEEEEECC
KARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADY
CCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
GAAVVVTGLDAAMDLANSLAPEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAG
CCEEEEECHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCEEEECCCCCCCCHHHHCC
PSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAAGYIQALARAEGLEGHARAIE
CCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEE
LREE
ECCC
>Mature Secondary Structure
MLPLIDGKEVKRRWSGRLLAREGVAARVREIIAAVKREGQAAVERYTLELDGVDLKEAGF
CCCCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHEEEEECCCCHHHHCC
RVTREEIGAAYRAVSPDLLEALRIARDNIATYHRRQPRGSWMETAADGTILGQICRPLGR
EEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHH
VGLYVPGGTAAYPSSVLMTAVPARVAGVREIALATPPRRDGTLPPLLLVAAAEAGVEEIY
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KMGGAQAVAALAYGTEKVAPVDKIAGPGNIYVTLAKKEVYGQVDIDMLAGPSEIVVIADG
HCCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEECHHCCCCCEEEECCCCEEEEEECC
KARPDWVAADLLSQAEHDALAGAVLITPDAGLARAVGEEVTRQLEALPRREIASRSLADY
CCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
GAAVVVTGLDAAMDLANSLAPEHLELYVSEPWSWLGRVENAGAIFLGPYSSEPLGDYLAG
CCEEEEECHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCEEEECCCCCCCCHHHHCC
PSHVLPTGGTARFYSPLSVDTFLKKSSLIACNRAGFRAAAGYIQALARAEGLEGHARAIE
CCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEE
LREE
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA