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The map label for this gene is hisG

Identifier: 83590866

GI number: 83590866

Start: 2125505

End: 2126191

Strand: Reverse

Name: hisG

Synonym: Moth_2036

Alternate gene names: 83590866

Gene position: 2126191-2125505 (Counterclockwise)

Preceding gene: 83590867

Following gene: 83590865

Centisome position: 80.88

GC content: 62.01

Gene sequence:

>687_bases
ATGGTAACCAACCTGCTCACCCTGGCCCTGCCGAAGGGTAAACTGGGCCAGGACGCCCTGCAATTATTACAGGCAGCCGG
GCTACCGGTAGAAGGGGTAGCTACCGAGGCCAGACAGCTGACCTTTACTTTTCCCGCCCCGGGGATACGCTATCTGATCT
GCCGGCCCACCGATGTACCGACCTATGTCGAATACGGGGCCGCCGACCTGGGCATCGTGGGGAAGGACACCCTGGCCGAG
GCCGGGGCCGATGTCTTTGAACTGGTGGACCTGGGTTTCGGCTACTGCCGCTTTGTGGTGGCCGCCCCCCGGGAGCGCTG
GGAGGAGGCCGGGCGATCCCTGGAAAACTTGCTGGCCGGCAGCCGGCGGGTGGCCACTAAGTTCCCCCGGGTGGCGGCTT
CCTTTTTCCAGGAACGGGGCCTCCCGGTGGAAATCATTAAATTGCACGGCAATATCGAGCTGGCGCCCCGGGCGGGACTG
GCGGACCTGATTGTCGATATTGTATCTACCGGCCGGACCTTAAAGGAGAATGACCTGGTGGAGGTAGCCCCCATTTTTTC
TTCTACCGCCCGCCTGATAGCCAACCGGGTCAGCTACCGCATAAATTACCGCCGCCTGACATCGGTGGTGGAAGCCCTGA
AGCGGGCGGCCGGCCAGGGGGGAGAAAAGATTGCTACCACTAATTGA

Upstream 100 bases:

>100_bases
CTAGCCGAGAACCACCGGAGGCCGGAGCTGTACCCTCCAGCCCCCAGGCTGGATGGTATTGACTTCCATTTTTACCAGAA
GTCTATTTTCGGAGGAAGTA

Downstream 100 bases:

>100_bases
TGGTAAAGAGGTAAAGCGCCGCTGGTCCGGGCGTCTCCTGGCCCGGGAAGGGGTGGCAGCCAGGGTGCGGGAGATTATTG
CCGCCGTGAAGAGGGAAGGC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MVTNLLTLALPKGKLGQDALQLLQAAGLPVEGVATEARQLTFTFPAPGIRYLICRPTDVPTYVEYGAADLGIVGKDTLAE
AGADVFELVDLGFGYCRFVVAAPRERWEEAGRSLENLLAGSRRVATKFPRVAASFFQERGLPVEIIKLHGNIELAPRAGL
ADLIVDIVSTGRTLKENDLVEVAPIFSSTARLIANRVSYRINYRRLTSVVEALKRAAGQGGEKIATTN

Sequences:

>Translated_228_residues
MVTNLLTLALPKGKLGQDALQLLQAAGLPVEGVATEARQLTFTFPAPGIRYLICRPTDVPTYVEYGAADLGIVGKDTLAE
AGADVFELVDLGFGYCRFVVAAPRERWEEAGRSLENLLAGSRRVATKFPRVAASFFQERGLPVEIIKLHGNIELAPRAGL
ADLIVDIVSTGRTLKENDLVEVAPIFSSTARLIANRVSYRINYRRLTSVVEALKRAAGQGGEKIATTN
>Mature_228_residues
MVTNLLTLALPKGKLGQDALQLLQAAGLPVEGVATEARQLTFTFPAPGIRYLICRPTDVPTYVEYGAADLGIVGKDTLAE
AGADVFELVDLGFGYCRFVVAAPRERWEEAGRSLENLLAGSRRVATKFPRVAASFFQERGLPVEIIKLHGNIELAPRAGL
ADLIVDIVSTGRTLKENDLVEVAPIFSSTARLIANRVSYRINYRRLTSVVEALKRAAGQGGEKIATTN

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=199, Percent_Identity=35.678391959799, Blast_Score=100, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=203, Percent_Identity=30.0492610837438, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_MOOTA (Q2RGV7)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430875.1
- ProteinModelPortal:   Q2RGV7
- SMR:   Q2RGV7
- STRING:   Q2RGV7
- GeneID:   3831411
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2036
- NMPDR:   fig|264732.9.peg.2057
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q2RGV7
- ProtClustDB:   PRK01686
- BioCyc:   MTHE264732:MOTH_2036-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24638; Mature: 24638

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTNLLTLALPKGKLGQDALQLLQAAGLPVEGVATEARQLTFTFPAPGIRYLICRPTDVP
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCEEEEEECCCCCC
TYVEYGAADLGIVGKDTLAEAGADVFELVDLGFGYCRFVVAAPRERWEEAGRSLENLLAG
HHHHCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
SRRVATKFPRVAASFFQERGLPVEIIKLHGNIELAPRAGLADLIVDIVSTGRTLKENDLV
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCCCE
EVAPIFSSTARLIANRVSYRINYRRLTSVVEALKRAAGQGGEKIATTN
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MVTNLLTLALPKGKLGQDALQLLQAAGLPVEGVATEARQLTFTFPAPGIRYLICRPTDVP
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCEEEEEECCCCCC
TYVEYGAADLGIVGKDTLAEAGADVFELVDLGFGYCRFVVAAPRERWEEAGRSLENLLAG
HHHHCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
SRRVATKFPRVAASFFQERGLPVEIIKLHGNIELAPRAGLADLIVDIVSTGRTLKENDLV
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCCCE
EVAPIFSSTARLIANRVSYRINYRRLTSVVEALKRAAGQGGEKIATTN
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA