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The map label for this gene is hisB

Identifier: 83590864

GI number: 83590864

Start: 2123650

End: 2124240

Strand: Reverse

Name: hisB

Synonym: Moth_2034

Alternate gene names: 83590864

Gene position: 2124240-2123650 (Counterclockwise)

Preceding gene: 83590865

Following gene: 83590863

Centisome position: 80.81

GC content: 63.62

Gene sequence:

>591_bases
ATGAGTCGCGAGGCCCTGATTGAGCGCCAGACCACGGAAACAAACATTCGCTTGAAGGTTGCCCTGGACGGGAGCGGTAC
CTGGCAGGGGAGCAGCGGTATCCCCTTCTTTGATCACCTCCTGGCCCAGATGGCCCGCCACGGCCTCTTGGACCTGAAGG
TCTGGGCCGAGGGAGACCTGGAGGTAGATAACCATCACACCGTCGAGGATATCGGCATCTGCCTCGGACAGGCCGTAAAA
AAGGCCCTGGGGGATAAGAAGGGGATTAGCCGTTACGGCAGTGCCCTGGTGCCCATGGACGAGGCCCTGGTGCTGGTAGC
CCTGGATTTCAGCGGCCGTCCCTACCTGGCCTGGGGCCTGGAACTCCCCCCGGGCCGGATTGGCAGCCTGGAGACGGAGC
TGGTGGAGGAGTTCCTGCGGGCCATGGTGAATAACAGCGGGCTGACCCTCCACGTCCGGCAACTGGCCGGCCATAACGCC
CACCACCTGGCGGAAGCCCTGTTCAAAGCCCTGGGTCGGGCCATCAGGCAGGCCGTCACCCTGGACCCGCGGGAGCAGGG
GATACCCTCCACCAAAGGTATCTTGTCGTAA

Upstream 100 bases:

>100_bases
GGGCTTCCGGGCTGCCGCGGGATATATCCAGGCTCTGGCCCGGGCCGAGGGCCTGGAGGGGCACGCCCGGGCCATCGAGC
TACGGGAGGAATGACCCGTC

Downstream 100 bases:

>100_bases
GAAGGGCATCGTGGCGGCAAGACACCAGGCGCCGGGAGTGAACCCCGGGCCGCTTAGGCGAGGAACAGGGAGCGAAGGAA
GACCAAGCCGGCTAATGAAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSREALIERQTTETNIRLKVALDGSGTWQGSSGIPFFDHLLAQMARHGLLDLKVWAEGDLEVDNHHTVEDIGICLGQAVK
KALGDKKGISRYGSALVPMDEALVLVALDFSGRPYLAWGLELPPGRIGSLETELVEEFLRAMVNNSGLTLHVRQLAGHNA
HHLAEALFKALGRAIRQAVTLDPREQGIPSTKGILS

Sequences:

>Translated_196_residues
MSREALIERQTTETNIRLKVALDGSGTWQGSSGIPFFDHLLAQMARHGLLDLKVWAEGDLEVDNHHTVEDIGICLGQAVK
KALGDKKGISRYGSALVPMDEALVLVALDFSGRPYLAWGLELPPGRIGSLETELVEEFLRAMVNNSGLTLHVRQLAGHNA
HHLAEALFKALGRAIRQAVTLDPREQGIPSTKGILS
>Mature_195_residues
SREALIERQTTETNIRLKVALDGSGTWQGSSGIPFFDHLLAQMARHGLLDLKVWAEGDLEVDNHHTVEDIGICLGQAVKK
ALGDKKGISRYGSALVPMDEALVLVALDFSGRPYLAWGLELPPGRIGSLETELVEEFLRAMVNNSGLTLHVRQLAGHNAH
HLAEALFKALGRAIRQAVTLDPREQGIPSTKGILS

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=46.9072164948454, Blast_Score=180, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=38.7096774193548, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_MOOTA (Q2RGV9)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430873.1
- HSSP:   P34047
- ProteinModelPortal:   Q2RGV9
- SMR:   Q2RGV9
- STRING:   Q2RGV9
- GeneID:   3831409
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2034
- NMPDR:   fig|264732.9.peg.2055
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q2RGV9
- BioCyc:   MTHE264732:MOTH_2034-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21332; Mature: 21201

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREALIERQTTETNIRLKVALDGSGTWQGSSGIPFFDHLLAQMARHGLLDLKVWAEGDL
CCCHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCE
EVDNHHTVEDIGICLGQAVKKALGDKKGISRYGSALVPMDEALVLVALDFSGRPYLAWGL
ECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECC
ELPPGRIGSLETELVEEFLRAMVNNSGLTLHVRQLAGHNAHHLAEALFKALGRAIRQAVT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHC
LDPREQGIPSTKGILS
CCCHHCCCCCCCCCCC
>Mature Secondary Structure 
SREALIERQTTETNIRLKVALDGSGTWQGSSGIPFFDHLLAQMARHGLLDLKVWAEGDL
CCHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCE
EVDNHHTVEDIGICLGQAVKKALGDKKGISRYGSALVPMDEALVLVALDFSGRPYLAWGL
ECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECC
ELPPGRIGSLETELVEEFLRAMVNNSGLTLHVRQLAGHNAHHLAEALFKALGRAIRQAVT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHC
LDPREQGIPSTKGILS
CCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA