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The map label for this gene is hisA

Identifier: 83590862

GI number: 83590862

Start: 2122183

End: 2122914

Strand: Reverse

Name: hisA

Synonym: Moth_2032

Alternate gene names: 83590862

Gene position: 2122914-2122183 (Counterclockwise)

Preceding gene: 83590863

Following gene: 83590861

Centisome position: 80.76

GC content: 66.26

Gene sequence:

>732_bases
ATGCTGGTAATGCCGGCCATTGATTTGCGGGAGGGGCGATGCGTGCGCCTCTACCAGGGACGTATCGAAGCCGAGACCGT
CTATTCCACGGATCCGGTGGCCGTTGCCCGGGGCTGGGTGGAACGGGGCGCCCGCTGGCTCCATGTGGTGGACCTGGACG
GCGCCTTTGCCGGCCGGCCGCGGAACCTGGAGGTTATTGCAGCCATTATCAGGGCCGCCGGGGTGCCGGTCCAGGTGGGC
GGCGGTATCCGCAGCCTGGAAAGCCTGGCGGGTGTCCTGGCAGCCGGGGCCTCCCGGGTGGTCCTGGGGACGGTAGCCAT
TACCAACCCGGAAGTTGTGGCCACGGCGGTGGAACGTTATGGCGAACGGGTGGTTGTCGGTATTGACAGCCTTGACGGCC
AGGTGGCCATCGAGGGCTGGGAAGCTACGGTAGCCAGGGGAGCAGTGGAGTTTGCCCGGCAAATGGCGTCCCTGGGGGTC
ACGCGGGCCGTTTTTACCGACATCGGCCGCGACGGCACCCTCCAGGGGCCCAACATTGCCGCCACCCGGGAGATGGCGCG
CAGCGGCGGCCTAAAGATCATTGCCTCCGGGGGTATTGCCAGCCTGGACGACCTCCGGAAGCTCAAGGAACTGGCAGCCG
AGGGAGTGGAAGGGGCCATCCTGGGTCGCTCCCTGTACAACGGCAATTTCACCCTGGAAGAGGCCCTGGCCGTAGCCGCA
GATGGAGATTAA

Upstream 100 bases:

>100_bases
AGCATCCAGAGGGGCAACCTCTTCGGGGTCCAGTTTCACCCGGAGAAGAGCAGCCGCCGGGGCCTGGAAGTTTTAAAGAA
TTTCGGGGAGTTGGTGCGCC

Downstream 100 bases:

>100_bases
AGGGCGGGGTGAATTCGCCTTTTGTAGAGCCAGCGGAAAGAGGCGGTATAGGTTGTTGACCAAAAGAATTATTCCCTGCC
TGGATGTTGACCACGGTCGG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLVMPAIDLREGRCVRLYQGRIEAETVYSTDPVAVARGWVERGARWLHVVDLDGAFAGRPRNLEVIAAIIRAAGVPVQVG
GGIRSLESLAGVLAAGASRVVLGTVAITNPEVVATAVERYGERVVVGIDSLDGQVAIEGWEATVARGAVEFARQMASLGV
TRAVFTDIGRDGTLQGPNIAATREMARSGGLKIIASGGIASLDDLRKLKELAAEGVEGAILGRSLYNGNFTLEEALAVAA
DGD

Sequences:

>Translated_243_residues
MLVMPAIDLREGRCVRLYQGRIEAETVYSTDPVAVARGWVERGARWLHVVDLDGAFAGRPRNLEVIAAIIRAAGVPVQVG
GGIRSLESLAGVLAAGASRVVLGTVAITNPEVVATAVERYGERVVVGIDSLDGQVAIEGWEATVARGAVEFARQMASLGV
TRAVFTDIGRDGTLQGPNIAATREMARSGGLKIIASGGIASLDDLRKLKELAAEGVEGAILGRSLYNGNFTLEEALAVAA
DGD
>Mature_243_residues
MLVMPAIDLREGRCVRLYQGRIEAETVYSTDPVAVARGWVERGARWLHVVDLDGAFAGRPRNLEVIAAIIRAAGVPVQVG
GGIRSLESLAGVLAAGASRVVLGTVAITNPEVVATAVERYGERVVVGIDSLDGQVAIEGWEATVARGAVEFARQMASLGV
TRAVFTDIGRDGTLQGPNIAATREMARSGGLKIIASGGIASLDDLRKLKELAAEGVEGAILGRSLYNGNFTLEEALAVAA
DGD

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=36.4754098360656, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1788336, Length=229, Percent_Identity=24.4541484716157, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_MOOTA (Q2RGW1)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430871.1
- ProteinModelPortal:   Q2RGW1
- SMR:   Q2RGW1
- STRING:   Q2RGW1
- GeneID:   3831407
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2032
- NMPDR:   fig|264732.9.peg.2053
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q2RGW1
- ProtClustDB:   PRK00748
- BioCyc:   MTHE264732:MOTH_2032-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25346; Mature: 25346

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVMPAIDLREGRCVRLYQGRIEAETVYSTDPVAVARGWVERGARWLHVVDLDGAFAGRP
CEECCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCC
RNLEVIAAIIRAAGVPVQVGGGIRSLESLAGVLAAGASRVVLGTVAITNPEVVATAVERY
CCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHC
GERVVVGIDSLDGQVAIEGWEATVARGAVEFARQMASLGVTRAVFTDIGRDGTLQGPNIA
CCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHH
ATREMARSGGLKIIASGGIASLDDLRKLKELAAEGVEGAILGRSLYNGNFTLEEALAVAA
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCEEECCCEEHHHHEEEEC
DGD
CCC
>Mature Secondary Structure
MLVMPAIDLREGRCVRLYQGRIEAETVYSTDPVAVARGWVERGARWLHVVDLDGAFAGRP
CEECCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCC
RNLEVIAAIIRAAGVPVQVGGGIRSLESLAGVLAAGASRVVLGTVAITNPEVVATAVERY
CCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHC
GERVVVGIDSLDGQVAIEGWEATVARGAVEFARQMASLGVTRAVFTDIGRDGTLQGPNIA
CCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHH
ATREMARSGGLKIIASGGIASLDDLRKLKELAAEGVEGAILGRSLYNGNFTLEEALAVAA
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCEEECCCEEHHHHEEEEC
DGD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA