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The map label for this gene is gcvT

Identifier: 83590777

GI number: 83590777

Start: 2018932

End: 2020032

Strand: Reverse

Name: gcvT

Synonym: Moth_1945

Alternate gene names: 83590777

Gene position: 2020032-2018932 (Counterclockwise)

Preceding gene: 83590778

Following gene: 83590776

Centisome position: 76.84

GC content: 62.67

Gene sequence:

>1101_bases
GTGGCCGATTTAAAAAAGACGCCCCTCTACGGGGAGCACGTGGCTGCCGGGGCCAAAATGGTGGAATTCGGCGGCTGGTT
GATGCCCGTCCAGTACAGCAGCATTATTGAGGAACATCAGCGGGTGCGTAACTGTGCCGGGCTCTTTGACGTCTCCCATA
TGGGGGAGATTACCATAAAGGGACCTGACGCCCTGGCGCTGGTCCAGAAGCTGCTTACCAACGATGCCGACCGGGCCACC
GGGGACAGGGTCATCTACAGCCCTATGTGTTACCCGGACGGGGGCGTAGTCGACGACCTGCTGGTCTATCCCCGGGGAGA
AGGGGAATATCTCCTGGTAGTCAACGCCGGTAACATTGACAAGGACTTTGCCTGGATCCAGGAGAACGCTAGCGGTTTCC
GGGTTGAGGTCAGCAATATCTCCGCAGCTACAGCTCAACTGGCCCTCCAGGGGCCACGAGCCCTGGAAATTCTCCGGCCC
CTGACGAGGGTCGACCTGGCCTCCCTGGGTTATTACCGCTGGACCGAGGGCCAGGTTCTGGGGGTTCATTGCCTGATCTC
CCGCACCGGCTACACCGGCGAAGACGGTTTCGAGCTTTACTTTGAGGCGGCCGCAGCCCCTACCATGTGGCGGAATATCC
TGGCCGCCGGCAGGGAGGCAGGCCTGGTCCCGGCCGGACTGGGGGCCAGGGATACTCTAAGGCTGGAGGCGGCCCTGCCC
CTTTACGGCCACGAGTTGGGCCCGGACATCAGCCCCCTGGAGGCCGGTTTGCACCGCTTTGTCCGCCTGGAGAAGGGCGA
ATTTAACGGGAGGGAGGCCCTGGCAGCCCAGCGGGAAGCCGGGGTCAGGAGGCAACTGGTGGGACTGACCATGATCGACC
GGGGGATCCCCCGGCCGGAATACCCCGTCCTGGCGGCAGGCAAGGAGATTGGTTACGTTACCTCAGGTTCCCTGGCGCCA
ACCCTGGGACAAAATATCGCTCTGGCCCTGGTGGCGGCAGGAACTGTCTCTACCGGCGGCGAAGTAGAAGTGAGCATCCG
CGGCCGTGTCAACCGCGCCCGGGTGGTGAAACTCCCCTTCTATCGCCGCCCCAAAAAGTAA

Upstream 100 bases:

>100_bases
CTGCCTAATCTCTCAGGTACCAGGACAGAGGCCATCACCGTTAAGGAACGGTGATGGCTTTTTTTGTGGACATACTAATA
GAAGTGAGGTGGAGTTATCA

Downstream 100 bases:

>100_bases
GCCGAAATCTTTTTAAAAGGAGGAATTAATGGCATGAATTTCCCGGCTCATCTGCATTATAGTAAAGACCATGAGTGGGT
AGAAGTCGATGGTAACCGTG

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MADLKKTPLYGEHVAAGAKMVEFGGWLMPVQYSSIIEEHQRVRNCAGLFDVSHMGEITIKGPDALALVQKLLTNDADRAT
GDRVIYSPMCYPDGGVVDDLLVYPRGEGEYLLVVNAGNIDKDFAWIQENASGFRVEVSNISAATAQLALQGPRALEILRP
LTRVDLASLGYYRWTEGQVLGVHCLISRTGYTGEDGFELYFEAAAAPTMWRNILAAGREAGLVPAGLGARDTLRLEAALP
LYGHELGPDISPLEAGLHRFVRLEKGEFNGREALAAQREAGVRRQLVGLTMIDRGIPRPEYPVLAAGKEIGYVTSGSLAP
TLGQNIALALVAAGTVSTGGEVEVSIRGRVNRARVVKLPFYRRPKK

Sequences:

>Translated_366_residues
MADLKKTPLYGEHVAAGAKMVEFGGWLMPVQYSSIIEEHQRVRNCAGLFDVSHMGEITIKGPDALALVQKLLTNDADRAT
GDRVIYSPMCYPDGGVVDDLLVYPRGEGEYLLVVNAGNIDKDFAWIQENASGFRVEVSNISAATAQLALQGPRALEILRP
LTRVDLASLGYYRWTEGQVLGVHCLISRTGYTGEDGFELYFEAAAAPTMWRNILAAGREAGLVPAGLGARDTLRLEAALP
LYGHELGPDISPLEAGLHRFVRLEKGEFNGREALAAQREAGVRRQLVGLTMIDRGIPRPEYPVLAAGKEIGYVTSGSLAP
TLGQNIALALVAAGTVSTGGEVEVSIRGRVNRARVVKLPFYRRPKK
>Mature_365_residues
ADLKKTPLYGEHVAAGAKMVEFGGWLMPVQYSSIIEEHQRVRNCAGLFDVSHMGEITIKGPDALALVQKLLTNDADRATG
DRVIYSPMCYPDGGVVDDLLVYPRGEGEYLLVVNAGNIDKDFAWIQENASGFRVEVSNISAATAQLALQGPRALEILRPL
TRVDLASLGYYRWTEGQVLGVHCLISRTGYTGEDGFELYFEAAAAPTMWRNILAAGREAGLVPAGLGARDTLRLEAALPL
YGHELGPDISPLEAGLHRFVRLEKGEFNGREALAAQREAGVRRQLVGLTMIDRGIPRPEYPVLAAGKEIGYVTSGSLAPT
LGQNIALALVAAGTVSTGGEVEVSIRGRVNRARVVKLPFYRRPKK

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=35.792349726776, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI257796258, Length=337, Percent_Identity=36.4985163204748, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI24797151, Length=341, Percent_Identity=32.258064516129, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=33.6088154269972, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=32.9073482428115, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=28.7037037037037, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=28.7037037037037, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI194306651, Length=404, Percent_Identity=25, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1789272, Length=373, Percent_Identity=40.2144772117962, Blast_Score=236, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=37.2654155495979, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71994052, Length=351, Percent_Identity=28.4900284900285, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994045, Length=351, Percent_Identity=28.4900284900285, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32563613, Length=346, Percent_Identity=26.3005780346821, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=34.020618556701, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129441, Length=386, Percent_Identity=35.2331606217617, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20130091, Length=430, Percent_Identity=24.6511627906977, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571104, Length=275, Percent_Identity=27.6363636363636, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_MOOTA (Q2RH46)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430786.1
- HSSP:   P27248
- ProteinModelPortal:   Q2RH46
- SMR:   Q2RH46
- STRING:   Q2RH46
- GeneID:   3832437
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1945
- NMPDR:   fig|264732.9.peg.1954
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- PhylomeDB:   Q2RH46
- BioCyc:   MTHE264732:MOTH_1945-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39640; Mature: 39509

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLKKTPLYGEHVAAGAKMVEFGGWLMPVQYSSIIEEHQRVRNCAGLFDVSHMGEITIK
CCCCCCCCCCCHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GPDALALVQKLLTNDADRATGDRVIYSPMCYPDGGVVDDLLVYPRGEGEYLLVVNAGNID
CCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCC
KDFAWIQENASGFRVEVSNISAATAQLALQGPRALEILRPLTRVDLASLGYYRWTEGQVL
CHHHHHHCCCCCEEEEECCCCHHHHHHEECCCHHHHHHHHHHHHHHHHCCCEEECCCCEE
GVHCLISRTGYTGEDGFELYFEAAAAPTMWRNILAAGREAGLVPAGLGARDTLRLEAALP
EEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECC
LYGHELGPDISPLEAGLHRFVRLEKGEFNGREALAAQREAGVRRQLVGLTMIDRGIPRPE
HHCHHCCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YPVLAAGKEIGYVTSGSLAPTLGQNIALALVAAGTVSTGGEVEVSIRGRVNRARVVKLPF
CCEEECCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCC
YRRPKK
CCCCCC
>Mature Secondary Structure 
ADLKKTPLYGEHVAAGAKMVEFGGWLMPVQYSSIIEEHQRVRNCAGLFDVSHMGEITIK
CCCCCCCCCCHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GPDALALVQKLLTNDADRATGDRVIYSPMCYPDGGVVDDLLVYPRGEGEYLLVVNAGNID
CCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCC
KDFAWIQENASGFRVEVSNISAATAQLALQGPRALEILRPLTRVDLASLGYYRWTEGQVL
CHHHHHHCCCCCEEEEECCCCHHHHHHEECCCHHHHHHHHHHHHHHHHCCCEEECCCCEE
GVHCLISRTGYTGEDGFELYFEAAAAPTMWRNILAAGREAGLVPAGLGARDTLRLEAALP
EEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECC
LYGHELGPDISPLEAGLHRFVRLEKGEFNGREALAAQREAGVRRQLVGLTMIDRGIPRPE
HHCHHCCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YPVLAAGKEIGYVTSGSLAPTLGQNIALALVAAGTVSTGGEVEVSIRGRVNRARVVKLPF
CCEEECCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCC
YRRPKK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA