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The map label for this gene is hemA

Identifier: 83590098

GI number: 83590098

Start: 1291756

End: 1293081

Strand: Reverse

Name: hemA

Synonym: Moth_1250

Alternate gene names: 83590098

Gene position: 1293081-1291756 (Counterclockwise)

Preceding gene: 83590099

Following gene: 83590097

Centisome position: 49.19

GC content: 58.14

Gene sequence:

>1326_bases
GTGTTTGTCGTTGCCGCCGGTCTAAATCATCGCACGGCGCCGGTAGCTATCCGGGAGCAGCTGGCCTTTGCTCGTCACGG
CCTGCCGCCTGCTTTATGCCGTCTAAAGGAAGAGGCTGGCGTTGAGGGTTGCGTTATTCTCAGTACCTGCAACCGCACTG
AAGTATATATAGCCTGTAACCAGGAGGAAGCTGGCCTAAAGGCGGCTAAAAACTTCCTGGGCCGCTCCTGTAAGCTGGCC
CTGGCAGACCTGGAAGGGTATCTCTATACTTTAAATACTCACCATGCTGTACGCCATCTGTTCCGCGTGGCTGCGGGCCT
GGATTCGATGATCCTGGGTGAAGACCAGGTCCTGGCCCAGGTAGCCGAAGCCTACCAGGTGGCCCGGGAAACGGGGACTA
CTAATAACGTCCTCAACACCCTCTGGCAGCAGGCTATTTACGCCGGCAAAAGGGTGCGCACGGAGACCCGGATTGATGCC
AATACAGTATCCGTCAGTTATGCGGCCGTAGAACTCGCCCGCCAGGTTTTTCATGATGAGCTGGACGGCCGGACGGTTTT
AGTAATCGGCGCCGGAAAGATGAGCACCCTGGCGGCCCGTTATCTTAAGGATAAAGGCGTCACTACTGTTCTGGTTTCCA
ACCGGTCTTACGACCGGGCCGTGGCCCTGGCTGCCACCATAGGCGGACAGGCCGTACGCCTGGACGCCCTGGAGGATTAT
TTACCCCGGGCTGATATCGTCATCAGCTGTACGGCGGCCAGCCATTATATCCTGCACCGGGACCAGGTGGCCCGGGCCGT
GGCGGCGCGCCCCGGGGTGCCCCTGATGCTCATTGATATTGCCGTACCCCGGGATATCGAACCTGCCGCCGGCGACCTGC
CGGGGGTAAAGCTCTATGATATTGACGATCTCCAGCAGGTGGTCCTGGCCAACCTGGAGGAAAGGAAAAAAGCAGCCCGG
CAGGCGGAGGGGATTATTGCGGCCGAGGCGGAGGCCTTTTTCCAGTGGCTGGGATCCCTCTATGTCGTGCCCACCATTGT
GGCCCTGAAGGAAAAGGCCGAGGCTATTAAAAATGCCGAGGTGCGCCGAGCCTGTAACCGCCTGGGGCAATTGACAACCA
GGGAGCAAAAGATAATCACTTCCATGGCCACAACTATTGTAAACCAGCTCCTCCATGACGCCATTGTCAATTTAAAAGCC
GCTGCACTTACCCCCCGGGGTCACCTCTATGTAGAGGCATTGCAGGAACTTTTCGAGCTGAGGGTCGATCACACCCTCCC
CGGCCCGGATATGGCCGTTTCGGTGGAAGGAGGCCGGAAGTATTGA

Upstream 100 bases:

>100_bases
AAAGGCGGGAGGAACTCCTGCGCCGCCTGGCCGGTGATGAAATCCTATTCCGCCTGGTGGCCCGGGGTAAAGAAGAACTG
GCAAAGGAGCGGGTCAAGCA

Downstream 100 bases:

>100_bases
TTGAAATTAAAGTGGGCTCCCGGGAGAGCGAACTGGCCCGCTGGCAGGCCCGCTGGGTGATCCAGGCCCTGGAGAAGGCC
TGGCCCGGGCTTAGCTGCCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFVVAAGLNHRTAPVAIREQLAFARHGLPPALCRLKEEAGVEGCVILSTCNRTEVYIACNQEEAGLKAAKNFLGRSCKLA
LADLEGYLYTLNTHHAVRHLFRVAAGLDSMILGEDQVLAQVAEAYQVARETGTTNNVLNTLWQQAIYAGKRVRTETRIDA
NTVSVSYAAVELARQVFHDELDGRTVLVIGAGKMSTLAARYLKDKGVTTVLVSNRSYDRAVALAATIGGQAVRLDALEDY
LPRADIVISCTAASHYILHRDQVARAVAARPGVPLMLIDIAVPRDIEPAAGDLPGVKLYDIDDLQQVVLANLEERKKAAR
QAEGIIAAEAEAFFQWLGSLYVVPTIVALKEKAEAIKNAEVRRACNRLGQLTTREQKIITSMATTIVNQLLHDAIVNLKA
AALTPRGHLYVEALQELFELRVDHTLPGPDMAVSVEGGRKY

Sequences:

>Translated_441_residues
MFVVAAGLNHRTAPVAIREQLAFARHGLPPALCRLKEEAGVEGCVILSTCNRTEVYIACNQEEAGLKAAKNFLGRSCKLA
LADLEGYLYTLNTHHAVRHLFRVAAGLDSMILGEDQVLAQVAEAYQVARETGTTNNVLNTLWQQAIYAGKRVRTETRIDA
NTVSVSYAAVELARQVFHDELDGRTVLVIGAGKMSTLAARYLKDKGVTTVLVSNRSYDRAVALAATIGGQAVRLDALEDY
LPRADIVISCTAASHYILHRDQVARAVAARPGVPLMLIDIAVPRDIEPAAGDLPGVKLYDIDDLQQVVLANLEERKKAAR
QAEGIIAAEAEAFFQWLGSLYVVPTIVALKEKAEAIKNAEVRRACNRLGQLTTREQKIITSMATTIVNQLLHDAIVNLKA
AALTPRGHLYVEALQELFELRVDHTLPGPDMAVSVEGGRKY
>Mature_441_residues
MFVVAAGLNHRTAPVAIREQLAFARHGLPPALCRLKEEAGVEGCVILSTCNRTEVYIACNQEEAGLKAAKNFLGRSCKLA
LADLEGYLYTLNTHHAVRHLFRVAAGLDSMILGEDQVLAQVAEAYQVARETGTTNNVLNTLWQQAIYAGKRVRTETRIDA
NTVSVSYAAVELARQVFHDELDGRTVLVIGAGKMSTLAARYLKDKGVTTVLVSNRSYDRAVALAATIGGQAVRLDALEDY
LPRADIVISCTAASHYILHRDQVARAVAARPGVPLMLIDIAVPRDIEPAAGDLPGVKLYDIDDLQQVVLANLEERKKAAR
QAEGIIAAEAEAFFQWLGSLYVVPTIVALKEKAEAIKNAEVRRACNRLGQLTTREQKIITSMATTIVNQLLHDAIVNLKA
AALTPRGHLYVEALQELFELRVDHTLPGPDMAVSVEGGRKY

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=39.0547263681592, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_MOOTA (Q2RJ25)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430107.1
- ProteinModelPortal:   Q2RJ25
- STRING:   Q2RJ25
- GeneID:   3833045
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1250
- NMPDR:   fig|264732.9.peg.1242
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q2RJ25
- ProtClustDB:   PRK00045
- BioCyc:   MTHE264732:MOTH_1250-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48019; Mature: 48019

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVAAGLNHRTAPVAIREQLAFARHGLPPALCRLKEEAGVEGCVILSTCNRTEVYIACN
CEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC
QEEAGLKAAKNFLGRSCKLALADLEGYLYTLNTHHAVRHLFRVAAGLDSMILGEDQVLAQ
CCHHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHHHCCCHHHCCCHHHHHH
VAEAYQVARETGTTNNVLNTLWQQAIYAGKRVRTETRIDANTVSVSYAAVELARQVFHDE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEHHHHHHHHHHHHHHHC
LDGRTVLVIGAGKMSTLAARYLKDKGVTTVLVSNRSYDRAVALAATIGGQAVRLDALEDY
CCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCHHEEEHHHCCCCEEEEHHHHHH
LPRADIVISCTAASHYILHRDQVARAVAARPGVPLMLIDIAVPRDIEPAAGDLPGVKLYD
CCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEC
IDDLQQVVLANLEERKKAARQAEGIIAAEAEAFFQWLGSLYVVPTIVALKEKAEAIKNAE
HHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRRACNRLGQLTTREQKIITSMATTIVNQLLHDAIVNLKAAALTPRGHLYVEALQELFEL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHHH
RVDHTLPGPDMAVSVEGGRKY
HHCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MFVVAAGLNHRTAPVAIREQLAFARHGLPPALCRLKEEAGVEGCVILSTCNRTEVYIACN
CEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC
QEEAGLKAAKNFLGRSCKLALADLEGYLYTLNTHHAVRHLFRVAAGLDSMILGEDQVLAQ
CCHHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHHHCCCHHHCCCHHHHHH
VAEAYQVARETGTTNNVLNTLWQQAIYAGKRVRTETRIDANTVSVSYAAVELARQVFHDE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEHHHHHHHHHHHHHHHC
LDGRTVLVIGAGKMSTLAARYLKDKGVTTVLVSNRSYDRAVALAATIGGQAVRLDALEDY
CCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCHHEEEHHHCCCCEEEEHHHHHH
LPRADIVISCTAASHYILHRDQVARAVAARPGVPLMLIDIAVPRDIEPAAGDLPGVKLYD
CCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEC
IDDLQQVVLANLEERKKAARQAEGIIAAEAEAFFQWLGSLYVVPTIVALKEKAEAIKNAE
HHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRRACNRLGQLTTREQKIITSMATTIVNQLLHDAIVNLKAAALTPRGHLYVEALQELFEL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHHH
RVDHTLPGPDMAVSVEGGRKY
HHCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA