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The map label for this gene is hemC

Identifier: 83590097

GI number: 83590097

Start: 1290818

End: 1291759

Strand: Reverse

Name: hemC

Synonym: Moth_1249

Alternate gene names: 83590097

Gene position: 1291759-1290818 (Counterclockwise)

Preceding gene: 83590098

Following gene: 83590096

Centisome position: 49.14

GC content: 65.18

Gene sequence:

>942_bases
TTGATTGAAATTAAAGTGGGCTCCCGGGAGAGCGAACTGGCCCGCTGGCAGGCCCGCTGGGTGATCCAGGCCCTGGAGAA
GGCCTGGCCCGGGCTTAGCTGCCGCCTGGTAACCCTTAAAACCAAGGGGGATAAAATTCTCGATGTGGCCCTGGCGCGGA
TTGGCGATAAGGGCCTTTTTACCAAAGAACTGGAACTGGCCCTCCTGGACGGGGCTATCGACCTGGCCGTCCACAGCATG
AAGGACATGCCCACGACTCTGCCGGAAGGCCTGGTCATCGGCGCCATCGGGCCACGGGAAGACCCGGCCGACGTCCTGGT
TTCCCCGGAGGGTTACACCCTGGCCACCCTGCCCATTAAGGCCCGGGTAGGAACCAGCAGCCTGCGGCGCAAGGCCCAGC
TGGCCTATGCCCGGCCGGACCTGGAACTGGTCGACCTGCGCGGTAATGTCCCCACCCGCCTGGCCAAAATGGAACGGGAC
GGTTTGACGGCCATTGTCCTGGCTGCCGCCGGGTTGAAGCGACTGAACCACGGCCAGGTTTTGGGGGAACCCATTCCCTA
CCATATCTGCCTGCCGGCCGTAGGTCAGGGGGCCATCGGCGTGGAGATCCGGGCCGGCGACCGCCGGGTGGCCGAACTGG
TGGCCGCCATCAACCATCCCCCCACAGCTGCCGCCGTCCGGGCGGAAAGGGCGTACTTACGCGCCCTGGAGGGAGGCTGC
CAGGTTCCCATCGCCGCCCTGGCCACCGTGGAGGATACTGCCCTGGTGTTGCAGGGAATGGTGGCCAGCCTGGATGGCCG
GGAAATGCTGCGGGATATTGCTTCCGGGAGTACCCGGGACCCGGAGGCTGCCGGCCGGGAACTGGCCCGGAAACTCCTCG
CCCGGGGTGCGGGTGAGATTTTGCAGGAGGTTAAGGCCCAAAGTGGAAAATACCAGGGGTAA

Upstream 100 bases:

>100_bases
ACCTCTATGTAGAGGCATTGCAGGAACTTTTCGAGCTGAGGGTCGATCACACCCTCCCCGGCCCGGATATGGCCGTTTCG
GTGGAAGGAGGCCGGAAGTA

Downstream 100 bases:

>100_bases
AGTTTTTTTAGTTGGTGCCGGCCCCGGCGACCCGGGCCTGTTGACTGTCAAAGGACGGGAGTGCCTGGCCCGGGCCGGGG
CTGTAGTCTACGATCGCTTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MIEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKELELALLDGAIDLAVHSM
KDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERD
GLTAIVLAAAGLKRLNHGQVLGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGC
QVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQEVKAQSGKYQG

Sequences:

>Translated_313_residues
MIEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKELELALLDGAIDLAVHSM
KDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERD
GLTAIVLAAAGLKRLNHGQVLGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGC
QVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQEVKAQSGKYQG
>Mature_313_residues
MIEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKELELALLDGAIDLAVHSM
KDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERD
GLTAIVLAAAGLKRLNHGQVLGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGC
QVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQEVKAQSGKYQG

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=48.2269503546099, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI66933009, Length=282, Percent_Identity=48.2269503546099, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI48994974, Length=301, Percent_Identity=49.8338870431894, Blast_Score=263, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=38.4858044164038, Blast_Score=198, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20130425, Length=319, Percent_Identity=39.8119122257053, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_MOOTA (Q2RJ26)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430106.1
- HSSP:   P06983
- ProteinModelPortal:   Q2RJ26
- SMR:   Q2RJ26
- STRING:   Q2RJ26
- GeneID:   3833044
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1249
- NMPDR:   fig|264732.9.peg.1241
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q2RJ26
- BioCyc:   MTHE264732:MOTH_1249-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33381; Mature: 33381

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLF
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCC
TKELELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIK
HHHHHHHEECCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEEEEEEE
ARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQV
EECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
LGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGC
CCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
QVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEI
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
LQEVKAQSGKYQG
HHHHHHCCCCCCC
>Mature Secondary Structure
MIEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLF
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCC
TKELELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIK
HHHHHHHEECCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEEEEEEE
ARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQV
EECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
LGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGC
CCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
QVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEI
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
LQEVKAQSGKYQG
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA