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The map label for this gene is hemB [H]

Identifier: 83590094

GI number: 83590094

Start: 1287089

End: 1288063

Strand: Reverse

Name: hemB [H]

Synonym: Moth_1246

Alternate gene names: 83590094

Gene position: 1288063-1287089 (Counterclockwise)

Preceding gene: 83590095

Following gene: 83590093

Centisome position: 49.0

GC content: 61.44

Gene sequence:

>975_bases
ATGACCGGTTTTCCTATTTGCCGGCCGCGGCGCCTGCGGCAGAACGCAACACTGAGGGCCATGGTCCGGGAGACGGAAAT
TAACCCCCGCGACCTGATTTATCCCCTCTTTGCCATCCACGGCCGGGGAGTAAAGAATCCCGTACCCTCCCTGCCCGGCG
TTTACCAGCTTTCCATCGATAATCTGGTACAGGAAGCCGGGGAAGTGGTGGCCGCCGGCATCCCGGCAGTCCTTCTCTTC
GGCATCCCGGCTACCAAGGACGAGGTCGGTTCCGGGGCTTACGACCCCCACGGCATCGTCCAGGAGGCCGTGCGGGCCCT
GAAAAAGGCCTACCCGGAACTCCTGATCATCACCGATGTCTGCCTGTGCGAGTACACCAGCCACGGCCACTGCGGCCTGG
TGGACGACGGCCAGGTCCTCAACGACCCTACCCTGGAGTTAATAGCTAAAACCGCCCTCTCCCACGTCGAAGCCGGGGCC
GATATCGTAGCGCCCTCGGATATGATGGACGGCCGGGTGGGGGCCATCCGCAAGCTCCTGGACGCCAACGGTTTTACCCA
GACCCCCATCCTGGCCTACTCGGCCAAGTATGCCTCCGTTTTTTACGGGCCCTTCCGGGATGCTGCCGGTTCGACACCCC
GGTTCGGCGACCGCCGGGGCTACCAGATGGACCCTGCCAACAGCGACGAGGCCCTGCGGGAAGTGGAACTCGACCTCCAG
GAGGGGGCCGACATGGTCATGGTGAAACCGGCCCTGCCTTACCTGGATATAATCCGCCGGGTGAAAGATAACTTTAACGT
CCCCCTGGCGGCCTACCAGGTCAGTGGCGAGTACGCCATGCTGAAAAGCGCCGCCGCCAACGGCTGGCTGGATGAAGAGA
AGAGCGTCCTCGAAGCCCTGACGGCCATCAAAAGGGCCGGTGCGGATCTTATTATCACTTATTACGCTAAAGATGTAGTC
AAGTGGCTTAAATGA

Upstream 100 bases:

>100_bases
ACTGCCGCGCCCGGGCGGAAAGCGTCACCGGCGACTTCTGGGAATCCGACCCAGCCTGTTATTTGACGGACGGGGAAATA
TCAGATAGGAGGTAGTTTTG

Downstream 100 bases:

>100_bases
TCTCACCCCTGATAGGGGGAAGGGTGATGGCGGCCACGCTGCCGGACGGGGCACCCCTCCATGGTGGACAGGTCCTGCCG
GCAGTAAGGAGGTTTTATAA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTGFPICRPRRLRQNATLRAMVRETEINPRDLIYPLFAIHGRGVKNPVPSLPGVYQLSIDNLVQEAGEVVAAGIPAVLLF
GIPATKDEVGSGAYDPHGIVQEAVRALKKAYPELLIITDVCLCEYTSHGHCGLVDDGQVLNDPTLELIAKTALSHVEAGA
DIVAPSDMMDGRVGAIRKLLDANGFTQTPILAYSAKYASVFYGPFRDAAGSTPRFGDRRGYQMDPANSDEALREVELDLQ
EGADMVMVKPALPYLDIIRRVKDNFNVPLAAYQVSGEYAMLKSAAANGWLDEEKSVLEALTAIKRAGADLIITYYAKDVV
KWLK

Sequences:

>Translated_324_residues
MTGFPICRPRRLRQNATLRAMVRETEINPRDLIYPLFAIHGRGVKNPVPSLPGVYQLSIDNLVQEAGEVVAAGIPAVLLF
GIPATKDEVGSGAYDPHGIVQEAVRALKKAYPELLIITDVCLCEYTSHGHCGLVDDGQVLNDPTLELIAKTALSHVEAGA
DIVAPSDMMDGRVGAIRKLLDANGFTQTPILAYSAKYASVFYGPFRDAAGSTPRFGDRRGYQMDPANSDEALREVELDLQ
EGADMVMVKPALPYLDIIRRVKDNFNVPLAAYQVSGEYAMLKSAAANGWLDEEKSVLEALTAIKRAGADLIITYYAKDVV
KWLK
>Mature_323_residues
TGFPICRPRRLRQNATLRAMVRETEINPRDLIYPLFAIHGRGVKNPVPSLPGVYQLSIDNLVQEAGEVVAAGIPAVLLFG
IPATKDEVGSGAYDPHGIVQEAVRALKKAYPELLIITDVCLCEYTSHGHCGLVDDGQVLNDPTLELIAKTALSHVEAGAD
IVAPSDMMDGRVGAIRKLLDANGFTQTPILAYSAKYASVFYGPFRDAAGSTPRFGDRRGYQMDPANSDEALREVELDLQE
GADMVMVKPALPYLDIIRRVKDNFNVPLAAYQVSGEYAMLKSAAANGWLDEEKSVLEALTAIKRAGADLIITYYAKDVVK
WLK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=49.5081967213115, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI87081728, Length=316, Percent_Identity=50.3164556962025, Blast_Score=308, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=44.2307692307692, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21358291, Length=306, Percent_Identity=46.7320261437908, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35304; Mature: 35173

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFPICRPRRLRQNATLRAMVRETEINPRDLIYPLFAIHGRGVKNPVPSLPGVYQLSID
CCCCCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHH
NLVQEAGEVVAAGIPAVLLFGIPATKDEVGSGAYDPHGIVQEAVRALKKAYPELLIITDV
HHHHHHHHHHHHCHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
CLCEYTSHGHCGLVDDGQVLNDPTLELIAKTALSHVEAGADIVAPSDMMDGRVGAIRKLL
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHHHCCHHHHHHHHH
DANGFTQTPILAYSAKYASVFYGPFRDAAGSTPRFGDRRGYQMDPANSDEALREVELDLQ
HCCCCCCCCHHEEECHHHHHEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EGADMVMVKPALPYLDIIRRVKDNFNVPLAAYQVSGEYAMLKSAAANGWLDEEKSVLEAL
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHH
TAIKRAGADLIITYYAKDVVKWLK
HHHHHCCCCEEEHHHHHHHHHHHC
>Mature Secondary Structure 
TGFPICRPRRLRQNATLRAMVRETEINPRDLIYPLFAIHGRGVKNPVPSLPGVYQLSID
CCCCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHH
NLVQEAGEVVAAGIPAVLLFGIPATKDEVGSGAYDPHGIVQEAVRALKKAYPELLIITDV
HHHHHHHHHHHHCHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
CLCEYTSHGHCGLVDDGQVLNDPTLELIAKTALSHVEAGADIVAPSDMMDGRVGAIRKLL
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHHHCCHHHHHHHHH
DANGFTQTPILAYSAKYASVFYGPFRDAAGSTPRFGDRRGYQMDPANSDEALREVELDLQ
HCCCCCCCCHHEEECHHHHHEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EGADMVMVKPALPYLDIIRRVKDNFNVPLAAYQVSGEYAMLKSAAANGWLDEEKSVLEAL
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHH
TAIKRAGADLIITYYAKDVVKWLK
HHHHHCCCCEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]