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The map label for this gene is pccB [H]

Identifier: 83313342

GI number: 83313342

Start: 4650700

End: 4652238

Strand: Reverse

Name: pccB [H]

Synonym: amb4243

Alternate gene names: 83313342

Gene position: 4652238-4650700 (Counterclockwise)

Preceding gene: 83313344

Following gene: 83313341

Centisome position: 93.66

GC content: 63.48

Gene sequence:

>1539_bases
ATGCACGAAATCATTCAGCAGCTCGAGGAAAAGAGGGAAGGCGCCCGTATGGGCGGTGGCGAGAAGCGCATCGCCGCCCA
ACACAAGCGCGGCAAGCTCACCGCGCGTGAGCGTATCGAGCTTCTCCTCGATCCCGATTCCTTCGAGGAATGGGACATGT
TCAAGGAGCATCGCTGCACCGACTTCGGCATGGATTCCGAAGACAACATGATCCCCGGCGACGGCGTGGTCACCGGCTAC
GGCACCATCAACGGCCGTCTGGTCTTCGTGTTCAGCCAGGACTTCACCGTATTCGGCGGCTCGCTGTCCGAGGCCCATGC
CGAGAAGATCTGCAAGATCATGGACAAGGCGGTCCAGGTCGGCGCCCCGGTCATCGGCCTCAACGATTCGGGCGGCGCCC
GCATCCAGGAAGGCGTCGCCTCCCTGGCCGGCTATGCCGAGGTCTTCCAGCGCAACGTCATGGCGTCCGGCGTGGTGCCC
CAGATCTCCATGATCATGGGCCCGTGCGCCGGCGGCGCCGTGTACTCCCCGGCCATGACCGACTACATCTTCATGGTCAA
GGACAGCTCGTACATGTTCGTGACCGGCCCGGACGTGGTCAAGACCGTCACCCACGAGACGGTGACCGCCGAGGAACTGG
GCGGCGCGGTGACCCACTCCACCAAGTCGGGCGTTGCCGATCTGGCCTTCGAGAACGACGTGGAGGCGCTGCTGCAGCTG
CGCCGCTTCATGGACTTCCTGCCCAGTTCCAACCGCGAGAAGCCGCCGGTGCGTCCCACCAGCGACGGGCCCGAGCGCAT
CGAGACCAGCCTCGACACCCTGATTCCCGACAACGCCAACAAGCCCTACGACATGAAGGAACTGATCCTCAAGGTCGTGG
ACGAAGGCGATTTCTTCGAGGTGCAGCCCGGCTATGCCGGCAACATCATCGTCGGCTTTGCCCGCATGGAAGGCCGCACG
GTGGGCATCGTCGCCAACCAGCCCATGGTGCTGGCCGGCTGTCTCGACATCTCGTCCTCCATCAAGGGCGCCCGCTTCGT
GCGCTTCTGCGATGCCTTCAACATTCCCATCGTCACCTTCGTGGACGTGCCCGGCTTCCTGCCCGGCACCAGCCAGGAAT
ACGGCGGCATCATCAAGCACGGCGCCAAGTTGCTGTACGCCTATGCCGAGTGCACGGTGCCCAAGATCACCGTCATCACC
CGCAAGGCCTATGGCGGCGCCTATGACGTGATGAGCTCCAAGCACCTGCGCGGCGACGTCAACTTCGCCTGGCCCACCGC
CGAGATCGCGGTGATGGGTCCCAAGGGCGCGGTGGAGATCATCTTCCGCTCCGATATCGGCGATGCGGAAAAGATCGCGG
CCCGCACCGAGGAATACCGCCAGAAGTTCGCCAATCCCTTCATCGCCGGGCATCGCGGCTTCATCGACGACGTCATCATG
CCTCGCAATACCAGGAAGCGCATCTGCCGCTCGCTGGCCATGCTGAAGGACAAGGACGTGAAGAATCCGTGGCGCAAGCA
CGGCAACATTCCGCTGTAA

Upstream 100 bases:

>100_bases
TCGCAACACCGCCCTTTTCCCGGCGACTCCTGTTGCAGCCATGGGGCTTTGCGAATAAGACCGACGCCAATGTCACTCTG
CCCGCCGGAGGCCCGCGTCC

Downstream 100 bases:

>100_bases
GGGGGACGATCGCATGTTCACTAAGATTCTGATCGCCAACCGCGGCGAAATCGCCTGTCGGGTCATCAAGACCGCCAAGA
AGATGGGCATCAAGACGGTG

Product: Acetyl-CoA carboxylase, carboxyltransferase component

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MHEIIQQLEEKREGARMGGGEKRIAAQHKRGKLTARERIELLLDPDSFEEWDMFKEHRCTDFGMDSEDNMIPGDGVVTGY
GTINGRLVFVFSQDFTVFGGSLSEAHAEKICKIMDKAVQVGAPVIGLNDSGGARIQEGVASLAGYAEVFQRNVMASGVVP
QISMIMGPCAGGAVYSPAMTDYIFMVKDSSYMFVTGPDVVKTVTHETVTAEELGGAVTHSTKSGVADLAFENDVEALLQL
RRFMDFLPSSNREKPPVRPTSDGPERIETSLDTLIPDNANKPYDMKELILKVVDEGDFFEVQPGYAGNIIVGFARMEGRT
VGIVANQPMVLAGCLDISSSIKGARFVRFCDAFNIPIVTFVDVPGFLPGTSQEYGGIIKHGAKLLYAYAECTVPKITVIT
RKAYGGAYDVMSSKHLRGDVNFAWPTAEIAVMGPKGAVEIIFRSDIGDAEKIAARTEEYRQKFANPFIAGHRGFIDDVIM
PRNTRKRICRSLAMLKDKDVKNPWRKHGNIPL

Sequences:

>Translated_512_residues
MHEIIQQLEEKREGARMGGGEKRIAAQHKRGKLTARERIELLLDPDSFEEWDMFKEHRCTDFGMDSEDNMIPGDGVVTGY
GTINGRLVFVFSQDFTVFGGSLSEAHAEKICKIMDKAVQVGAPVIGLNDSGGARIQEGVASLAGYAEVFQRNVMASGVVP
QISMIMGPCAGGAVYSPAMTDYIFMVKDSSYMFVTGPDVVKTVTHETVTAEELGGAVTHSTKSGVADLAFENDVEALLQL
RRFMDFLPSSNREKPPVRPTSDGPERIETSLDTLIPDNANKPYDMKELILKVVDEGDFFEVQPGYAGNIIVGFARMEGRT
VGIVANQPMVLAGCLDISSSIKGARFVRFCDAFNIPIVTFVDVPGFLPGTSQEYGGIIKHGAKLLYAYAECTVPKITVIT
RKAYGGAYDVMSSKHLRGDVNFAWPTAEIAVMGPKGAVEIIFRSDIGDAEKIAARTEEYRQKFANPFIAGHRGFIDDVIM
PRNTRKRICRSLAMLKDKDVKNPWRKHGNIPL
>Mature_512_residues
MHEIIQQLEEKREGARMGGGEKRIAAQHKRGKLTARERIELLLDPDSFEEWDMFKEHRCTDFGMDSEDNMIPGDGVVTGY
GTINGRLVFVFSQDFTVFGGSLSEAHAEKICKIMDKAVQVGAPVIGLNDSGGARIQEGVASLAGYAEVFQRNVMASGVVP
QISMIMGPCAGGAVYSPAMTDYIFMVKDSSYMFVTGPDVVKTVTHETVTAEELGGAVTHSTKSGVADLAFENDVEALLQL
RRFMDFLPSSNREKPPVRPTSDGPERIETSLDTLIPDNANKPYDMKELILKVVDEGDFFEVQPGYAGNIIVGFARMEGRT
VGIVANQPMVLAGCLDISSSIKGARFVRFCDAFNIPIVTFVDVPGFLPGTSQEYGGIIKHGAKLLYAYAECTVPKITVIT
RKAYGGAYDVMSSKHLRGDVNFAWPTAEIAVMGPKGAVEIIFRSDIGDAEKIAARTEEYRQKFANPFIAGHRGFIDDVIM
PRNTRKRICRSLAMLKDKDVKNPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=70.8086785009862, Blast_Score=751, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=68.1214421252372, Blast_Score=738, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=502, Percent_Identity=33.6653386454183, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679960, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679971, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679977, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679967, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679974, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=510, Percent_Identity=67.843137254902, Blast_Score=735, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=510, Percent_Identity=67.843137254902, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=503, Percent_Identity=33.2007952286282, Blast_Score=255, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71997163, Length=346, Percent_Identity=24.2774566473988, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=388, Percent_Identity=20.1030927835052, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24586065, Length=508, Percent_Identity=33.4645669291339, Blast_Score=230, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56168; Mature: 56168

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEIIQQLEEKREGARMGGGEKRIAAQHKRGKLTARERIELLLDPDSFEEWDMFKEHRCT
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCEEEEECCCCCHHHHHHHHCCCC
DFGMDSEDNMIPGDGVVTGYGTINGRLVFVFSQDFTVFGGSLSEAHAEKICKIMDKAVQV
CCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
GAPVIGLNDSGGARIQEGVASLAGYAEVFQRNVMASGVVPQISMIMGPCAGGAVYSPAMT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCC
DYIFMVKDSSYMFVTGPDVVKTVTHETVTAEELGGAVTHSTKSGVADLAFENDVEALLQL
CEEEEEECCCEEEEECCHHHHHHHHHHEEHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RRFMDFLPSSNREKPPVRPTSDGPERIETSLDTLIPDNANKPYDMKELILKVVDEGDFFE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEE
VQPGYAGNIIVGFARMEGRTVGIVANQPMVLAGCLDISSSIKGARFVRFCDAFNIPIVTF
ECCCCCCCEEEEEEEECCEEEEEEECCCEEEEEEHHHHHCCCHHHHHHHHHCCCCCEEEE
VDVPGFLPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDV
ECCCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCC
NFAWPTAEIAVMGPKGAVEIIFRSDIGDAEKIAARTEEYRQKFANPFIAGHRGFIDDVIM
EEECCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCC
PRNTRKRICRSLAMLKDKDVKNPWRKHGNIPL
CCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MHEIIQQLEEKREGARMGGGEKRIAAQHKRGKLTARERIELLLDPDSFEEWDMFKEHRCT
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCEEEEECCCCCHHHHHHHHCCCC
DFGMDSEDNMIPGDGVVTGYGTINGRLVFVFSQDFTVFGGSLSEAHAEKICKIMDKAVQV
CCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
GAPVIGLNDSGGARIQEGVASLAGYAEVFQRNVMASGVVPQISMIMGPCAGGAVYSPAMT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCC
DYIFMVKDSSYMFVTGPDVVKTVTHETVTAEELGGAVTHSTKSGVADLAFENDVEALLQL
CEEEEEECCCEEEEECCHHHHHHHHHHEEHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RRFMDFLPSSNREKPPVRPTSDGPERIETSLDTLIPDNANKPYDMKELILKVVDEGDFFE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEE
VQPGYAGNIIVGFARMEGRTVGIVANQPMVLAGCLDISSSIKGARFVRFCDAFNIPIVTF
ECCCCCCCEEEEEEEECCEEEEEEECCCEEEEEEHHHHHCCCHHHHHHHHHCCCCCEEEE
VDVPGFLPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDV
ECCCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCC
NFAWPTAEIAVMGPKGAVEIIFRSDIGDAEKIAARTEEYRQKFANPFIAGHRGFIDDVIM
EEECCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCC
PRNTRKRICRSLAMLKDKDVKNPWRKHGNIPL
CCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]