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The map label for this gene is bhbA [H]

Identifier: 83313339

GI number: 83313339

Start: 4646308

End: 4648017

Strand: Reverse

Name: bhbA [H]

Synonym: amb4240

Alternate gene names: 83313339

Gene position: 4648017-4646308 (Counterclockwise)

Preceding gene: 83313340

Following gene: 83313338

Centisome position: 93.58

GC content: 65.26

Gene sequence:

>1710_bases
ATGAGCGAGTTCCCGAAGAAGAGCGTTTCCGATTGGGAAGCCCTGGCGTCGAAGGACCTCAAGGGCGCCTCGCCCTCGAC
CCTGGACTGGGAAACCCCGGAAGGCATCAAGGTCAAGCCGCTCTACACCGCCGCCGACTTGGAAGGCATGGATCATCTGG
GCTCGCTGCCCGGCTTCCCGCCCTTCACCCGCGGTCCCCGCGCCACCATGTACGCGGCCAAGCCGTGGACGGTGCGCCAG
TACGCGGGCTTCTCCACCGCCGAGGAATCCAACGCCTTCTACCGCAAGAACCTCGCCGCCGGGCAGCAGGGCATTTCGGT
GGCCTTCGATCTGGCCACCCATCGCGGCTATGATTCCGATCACCCCCGCGTGGTGGGCGACGTGGGCAAGGCGGGCGTCG
CCATCGATTCCGTCGAGGATATGAAGATCCTGTTCGACGGCATCCCGCTGGACAAGATGTCGGTCTCCATGACCATGAAC
GGCGCCGTTCTTCCCGTGCTGGCCGGCTATATCGTCGCCGCCGAGGAACAGGGCGTCTCCCAGGACCAGCTGTCGGGCAC
CATCCAGAACGACATCCTGAAGGAGTTCATGGTCCGCAACACCTACATCTATCCGCCGGCTCCCAGCATGCGGATCATCG
CGGACATCATCGAGTACACCTCGAAGAACATGCCCAAGTTCAACTCCATCTCCATCTCCGGCTACCACATGCAGGAAGCC
GGGGCGACGGCGGTGCAGGAATTGGCCTTCACCCTGGCCGACGGCCTGGAATACGTGCGCGCCGCCCTGGGCACCGGGCT
CAAGATCGACGAGTTCGCCGGCCGCCTGTCGTTCTTCTGGGCCATCGGCATGAACTTCTTCATGGAGATCGCCAAGATGC
GCGCCGGCCGCCTGCTGTGGGCCCGCATCATCAAGCAGTTCGATCCGCAGAAGCCTTCGTCCATGGCGCTGCGCACCCAT
TGCCAGACCTCGGGCGTCAGCCTCACCGAGAAGGACGCCTACAACAACGTCGTCCGCACCACCATCGAGGCCATGGCCGC
CGTTCTGGGCGGCACCCAGTCGCTGCACACCAACGCGCTGGACGAGGCCATCGCGCTGCCCACGCCGTTCTCGGCCCGCA
TCGCGCGCAACACCCAGCTGATCATCCAGGAAGAGACCGGCATTCCCCATGTGGTCGACCCCCTGGCCGGCTCCTACTAC
GTCGAAAGCCTGACCAACGCTCTGGCCGAGGAAGCCTGGAAGCTGATCCAGGAAGTGGAAGAGCTGGGCGGCATGACCAA
GGCCGTGGAATCCGGCATGCCCAAGATGAAGATCGAGGAGGCCGCCGCCCGCCGTCAGGCCCGCATCGACCGCGGCGAAG
AGGTCGTGGTCGGCGTCAACAAATACCAGCCGGCGGAAGAGACCCCCATCGAGATTCTCGACGTGGACAACGCCAAGGTG
CGCGAATCCCAGATCGCCCGCCTCAAGCAGATCAAGGCGACCCGCGACCAGGCCAAGTGCGATGCCGCCCTGGCCGCCCT
GGCCAAGGCGGGCGAGACCGGCGAAGGCAATCTGCTGGCCTGGCCGTCGAGGCCACCCGTGCCCGCGCCACCGTCGGCGA
GATTTCCGATGCGCTGGAGACGTCCTTCACCCGTCACCGCGCCGTCAACCGGACCATCTCCGGCGTCTATGGCGGCGTGT
ACAAGGATGACGCGGGCTTCGCCAAGCTGA

Upstream 100 bases:

>100_bases
CCTGGGCCCCACGGTGGCGGGGTTGAAGTCGCTGGATGAATTTGGCGCGTCCTATCTTATGCGTGGCGCGGCGTTTTAAA
AAACAGAAGGGAGAGGGACC

Downstream 100 bases:

>100_bases
AGGCCGATATCGAGGACTTCGCCAAGGCCGAGGGCCGCCGTCCCCGCATGCTGGTCTGCAAGATGGGCCAGGACGGCCAC
GATCGCGGCGCCAAGGTGAT

Product: methylmalonyl-CoA mutase N-terminal domain-containing protein

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSEFPKKSVSDWEALASKDLKGASPSTLDWETPEGIKVKPLYTAADLEGMDHLGSLPGFPPFTRGPRATMYAAKPWTVRQ
YAGFSTAEESNAFYRKNLAAGQQGISVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDKMSVSMTMN
GAVLPVLAGYIVAAEEQGVSQDQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIADIIEYTSKNMPKFNSISISGYHMQEA
GATAVQELAFTLADGLEYVRAALGTGLKIDEFAGRLSFFWAIGMNFFMEIAKMRAGRLLWARIIKQFDPQKPSSMALRTH
CQTSGVSLTEKDAYNNVVRTTIEAMAAVLGGTQSLHTNALDEAIALPTPFSARIARNTQLIIQEETGIPHVVDPLAGSYY
VESLTNALAEEAWKLIQEVEELGGMTKAVESGMPKMKIEEAAARRQARIDRGEEVVVGVNKYQPAEETPIEILDVDNAKV
RESQIARLKQIKATRDQAKCDAALAALAKAGETGEGNLLAWPSRPPVPAPPSARFPMRWRRPSPVTAPSTGPSPASMAAC
TRMTRASPS

Sequences:

>Translated_569_residues
MSEFPKKSVSDWEALASKDLKGASPSTLDWETPEGIKVKPLYTAADLEGMDHLGSLPGFPPFTRGPRATMYAAKPWTVRQ
YAGFSTAEESNAFYRKNLAAGQQGISVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDKMSVSMTMN
GAVLPVLAGYIVAAEEQGVSQDQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIADIIEYTSKNMPKFNSISISGYHMQEA
GATAVQELAFTLADGLEYVRAALGTGLKIDEFAGRLSFFWAIGMNFFMEIAKMRAGRLLWARIIKQFDPQKPSSMALRTH
CQTSGVSLTEKDAYNNVVRTTIEAMAAVLGGTQSLHTNALDEAIALPTPFSARIARNTQLIIQEETGIPHVVDPLAGSYY
VESLTNALAEEAWKLIQEVEELGGMTKAVESGMPKMKIEEAAARRQARIDRGEEVVVGVNKYQPAEETPIEILDVDNAKV
RESQIARLKQIKATRDQAKCDAALAALAKAGETGEGNLLAWPSRPPVPAPPSARFPMRWRRPSPVTAPSTGPSPASMAAC
TRMTRASPS
>Mature_568_residues
SEFPKKSVSDWEALASKDLKGASPSTLDWETPEGIKVKPLYTAADLEGMDHLGSLPGFPPFTRGPRATMYAAKPWTVRQY
AGFSTAEESNAFYRKNLAAGQQGISVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDKMSVSMTMNG
AVLPVLAGYIVAAEEQGVSQDQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIADIIEYTSKNMPKFNSISISGYHMQEAG
ATAVQELAFTLADGLEYVRAALGTGLKIDEFAGRLSFFWAIGMNFFMEIAKMRAGRLLWARIIKQFDPQKPSSMALRTHC
QTSGVSLTEKDAYNNVVRTTIEAMAAVLGGTQSLHTNALDEAIALPTPFSARIARNTQLIIQEETGIPHVVDPLAGSYYV
ESLTNALAEEAWKLIQEVEELGGMTKAVESGMPKMKIEEAAARRQARIDRGEEVVVGVNKYQPAEETPIEILDVDNAKVR
ESQIARLKQIKATRDQAKCDAALAALAKAGETGEGNLLAWPSRPPVPAPPSARFPMRWRRPSPVTAPSTGPSPASMAACT
RMTRASPS

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=511, Percent_Identity=69.4716242661448, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=510, Percent_Identity=66.8627450980392, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=510, Percent_Identity=67.4509803921569, Blast_Score=707, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 61805; Mature: 61674

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFPKKSVSDWEALASKDLKGASPSTLDWETPEGIKVKPLYTAADLEGMDHLGSLPGFP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHCCCCCCC
PFTRGPRATMYAAKPWTVRQYAGFSTAEESNAFYRKNLAAGQQGISVAFDLATHRGYDSD
CCCCCCCCEEEECCCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
HPRVVGDVGKAGVAIDSVEDMKILFDGIPLDKMSVSMTMNGAVLPVLAGYIVAAEEQGVS
CCEEEECCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHEEECCCCCC
QDQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIADIIEYTSKNMPKFNSISISGYHMQEA
HHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECEEEHHH
GATAVQELAFTLADGLEYVRAALGTGLKIDEFAGRLSFFWAIGMNFFMEIAKMRAGRLLW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARIIKQFDPQKPSSMALRTHCQTSGVSLTEKDAYNNVVRTTIEAMAAVLGGTQSLHTNAL
HHHHHHCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEAIALPTPFSARIARNTQLIIQEETGIPHVVDPLAGSYYVESLTNALAEEAWKLIQEVE
HHHHCCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGGMTKAVESGMPKMKIEEAAARRQARIDRGEEVVVGVNKYQPAEETPIEILDVDNAKV
HHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCHH
RESQIARLKQIKATRDQAKCDAALAALAKAGETGEGNLLAWPSRPPVPAPPSARFPMRWR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
RPSPVTAPSTGPSPASMAACTRMTRASPS
CCCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEFPKKSVSDWEALASKDLKGASPSTLDWETPEGIKVKPLYTAADLEGMDHLGSLPGFP
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHCCCCCCC
PFTRGPRATMYAAKPWTVRQYAGFSTAEESNAFYRKNLAAGQQGISVAFDLATHRGYDSD
CCCCCCCCEEEECCCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
HPRVVGDVGKAGVAIDSVEDMKILFDGIPLDKMSVSMTMNGAVLPVLAGYIVAAEEQGVS
CCEEEECCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHEEECCCCCC
QDQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIADIIEYTSKNMPKFNSISISGYHMQEA
HHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECEEEHHH
GATAVQELAFTLADGLEYVRAALGTGLKIDEFAGRLSFFWAIGMNFFMEIAKMRAGRLLW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARIIKQFDPQKPSSMALRTHCQTSGVSLTEKDAYNNVVRTTIEAMAAVLGGTQSLHTNAL
HHHHHHCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEAIALPTPFSARIARNTQLIIQEETGIPHVVDPLAGSYYVESLTNALAEEAWKLIQEVE
HHHHCCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGGMTKAVESGMPKMKIEEAAARRQARIDRGEEVVVGVNKYQPAEETPIEILDVDNAKV
HHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCHH
RESQIARLKQIKATRDQAKCDAALAALAKAGETGEGNLLAWPSRPPVPAPPSARFPMRWR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
RPSPVTAPSTGPSPASMAACTRMTRASPS
CCCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]