Click here to switch to the map view.

The map label for this gene is mutB [H]

Identifier: 83313338

GI number: 83313338

Start: 4645868

End: 4646341

Strand: Reverse

Name: mutB [H]

Synonym: amb4239

Alternate gene names: 83313338

Gene position: 4646341-4645868 (Counterclockwise)

Preceding gene: 83313339

Following gene: 83313336

Centisome position: 93.54

GC content: 67.72

Gene sequence:

>474_bases
GTGTACAAGGATGACGCGGGCTTCGCCAAGCTGAAGGCCGATATCGAGGACTTCGCCAAGGCCGAGGGCCGCCGTCCCCG
CATGCTGGTCTGCAAGATGGGCCAGGACGGCCACGATCGCGGCGCCAAGGTGATCGCTACCGCTTTCGCCGATCTGGGCT
TCGACGTGGATATCGGGCCGCTGTTCCAGACACCGGAAGAGGCCGCCCGCCAGGCGGTGGAGAACGACGTGCACATCGTC
GCCGCCTCCTCCCTGGCCGCCGGCCACAAGACCCTGGTCCCCTCGCTGATCGCCGAGTTGAAGGCCCAGGGCGCCGGCGA
CATCCTGGTGGTGACCGGCGGCGTCATTCCCACCCAGGATTACGACTTCCTGTACAAGGCCGGCGTGGCGGCGGTGTACG
GCCCCGGGACCAACATCCCCAAGGCCGCCGCCGAGATCCTGGAACTGCTGAAGAAGCGCGGCAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGTGCCCGCGCCACCGTCGGCGAGATTTCCGATGCGCTGGAGACGTCCTTCACCCGTCACCGCGCCGTCAACCGGACCA
TCTCCGGCGTCTATGGCGGC

Downstream 100 bases:

>100_bases
TCGCGGCAAGGCCAAGGCACGGACGGACGGGCGGGAAGGCGACTTCCCGCCCGTTTTCATTGGCGCTCCAACCTTATTCA
ATCCAGGGAATCGTAAAAGG

Product: methylmalonyl-CoA mutase C-terminal domain-containing protein

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MYKDDAGFAKLKADIEDFAKAEGRRPRMLVCKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEEAARQAVENDVHIV
AASSLAAGHKTLVPSLIAELKAQGAGDILVVTGGVIPTQDYDFLYKAGVAAVYGPGTNIPKAAAEILELLKKRGKAA

Sequences:

>Translated_157_residues
MYKDDAGFAKLKADIEDFAKAEGRRPRMLVCKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEEAARQAVENDVHIV
AASSLAAGHKTLVPSLIAELKAQGAGDILVVTGGVIPTQDYDFLYKAGVAAVYGPGTNIPKAAAEILELLKKRGKAA
>Mature_157_residues
MYKDDAGFAKLKADIEDFAKAEGRRPRMLVCKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEEAARQAVENDVHIV
AASSLAAGHKTLVPSLIAELKAQGAGDILVVTGGVIPTQDYDFLYKAGVAAVYGPGTNIPKAAAEILELLKKRGKAA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=138, Percent_Identity=68.8405797101449, Blast_Score=202, Evalue=1e-52,
Organism=Escherichia coli, GI1789284, Length=150, Percent_Identity=60.6666666666667, Blast_Score=190, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25144500, Length=154, Percent_Identity=63.6363636363636, Blast_Score=197, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 16522; Mature: 16522

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDDAGFAKLKADIEDFAKAEGRRPRMLVCKMGQDGHDRGAKVIATAFADLGFDVDIGP
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
LFQTPEEAARQAVENDVHIVAASSLAAGHKTLVPSLIAELKAQGAGDILVVTGGVIPTQD
CCCCHHHHHHHHHHCCEEEEEECCHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
YDFLYKAGVAAVYGPGTNIPKAAAEILELLKKRGKAA
CHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYKDDAGFAKLKADIEDFAKAEGRRPRMLVCKMGQDGHDRGAKVIATAFADLGFDVDIGP
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
LFQTPEEAARQAVENDVHIVAASSLAAGHKTLVPSLIAELKAQGAGDILVVTGGVIPTQD
CCCCHHHHHHHHHHCCEEEEEECCHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
YDFLYKAGVAAVYGPGTNIPKAAAEILELLKKRGKAA
CHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]