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The map label for this gene is hbdA [H]

Identifier: 83313001

GI number: 83313001

Start: 4317645

End: 4318523

Strand: Reverse

Name: hbdA [H]

Synonym: amb3902

Alternate gene names: 83313001

Gene position: 4318523-4317645 (Counterclockwise)

Preceding gene: 83313002

Following gene: 83313000

Centisome position: 86.94

GC content: 62.91

Gene sequence:

>879_bases
ATGACTGCTATCAATAAGATCGGTGTTATCGGCGCGGGCCAGATGGGCAATGGTATCGCCCAAGTCTGCGCTGCCGCCGG
TTTCGACGTTATCCTGCTCGACGTCAGCGAGGAGGCCCTGAAGAAGGGTCTTGGCACCATCACCAAGAACCTGGACCGCG
CCCTTTCCAAGGGCAAGCTGACCGAGGCCGAAAAAGCTGCCACGCTCGGTCACATCAAGACCACCACCGCCTATGCCGAT
TTCTCGGATAGCGATCTGGTCATCGAGGCCGCCACCGAGGATGAGAAGATCAAGCGGGCCATCTTCGCCCAGCTCTGCCC
GGTGCTGAAGCCCGAGGCCCATATCGCGTCCAACACCTCGTCGCTGTCCATCACCCGCCTGGGTGCCGCCACCGACCGTC
CCGCCAAGTTCATGGGCATGCACTTCATGAACCCGGTGCCGGTCATGAAGCTGGTGGAATTGATCCGCGGCATCGCCACC
AGCGAGGAGACCTTCTCCCTGGTGACCGAGATGACCCAGAAGCTGGGCAAGAAGGCAGTGGCCGCCGAGGACTTCCCGGC
CTTCATCGTCAACCGCATCCTGCTGCCCATGATCAACGAAGCCGTCTACACCCTGTACGAGGGCGTCGGCTCGGTGGCCA
GCATCGATACCGCCATGAAGCTGGGCGCCAACCACCCCATGGGTCCGCTGGAACTGGCCGACTTCATCGGTCTGGACACC
TGTCTGGCGGTGATGCAGGTCCTGCACGAGGGCCTCGCCGACACCAAGTATCGCCCCTGCCCGCTGCTGGTGAAGTATGT
GGAGGCCGGCTGGCTGGGCCGCAAGACCGGCCGCGGCTTCTACGATTACACCGGCGAGACCCCGGTTCCGACCCGCTAA

Upstream 100 bases:

>100_bases
CGCGGATCTCTTCAAGGTGTTGCCGGAGCTGGCCTCCGAACTCAACAAGTAACCGTCAACCTGCCCTACGGCTGAAGCCA
TAGTATCCGGGAGCCTCATA

Downstream 100 bases:

>100_bases
ATCAGCGGTTCCGGACGGAACGCAGGGCGGGAGGCCATGGCCTCCCGCCCTTTTTCGTTTGGCGGCGGCCTATGGAACTT
CATGTTTTATACACCACTAT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTAINKIGVIGAGQMGNGIAQVCAAAGFDVILLDVSEEALKKGLGTITKNLDRALSKGKLTEAEKAATLGHIKTTTAYAD
FSDSDLVIEAATEDEKIKRAIFAQLCPVLKPEAHIASNTSSLSITRLGAATDRPAKFMGMHFMNPVPVMKLVELIRGIAT
SEETFSLVTEMTQKLGKKAVAAEDFPAFIVNRILLPMINEAVYTLYEGVGSVASIDTAMKLGANHPMGPLELADFIGLDT
CLAVMQVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGRGFYDYTGETPVPTR

Sequences:

>Translated_292_residues
MTAINKIGVIGAGQMGNGIAQVCAAAGFDVILLDVSEEALKKGLGTITKNLDRALSKGKLTEAEKAATLGHIKTTTAYAD
FSDSDLVIEAATEDEKIKRAIFAQLCPVLKPEAHIASNTSSLSITRLGAATDRPAKFMGMHFMNPVPVMKLVELIRGIAT
SEETFSLVTEMTQKLGKKAVAAEDFPAFIVNRILLPMINEAVYTLYEGVGSVASIDTAMKLGANHPMGPLELADFIGLDT
CLAVMQVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGRGFYDYTGETPVPTR
>Mature_291_residues
TAINKIGVIGAGQMGNGIAQVCAAAGFDVILLDVSEEALKKGLGTITKNLDRALSKGKLTEAEKAATLGHIKTTTAYADF
SDSDLVIEAATEDEKIKRAIFAQLCPVLKPEAHIASNTSSLSITRLGAATDRPAKFMGMHFMNPVPVMKLVELIRGIATS
EETFSLVTEMTQKLGKKAVAAEDFPAFIVNRILLPMINEAVYTLYEGVGSVASIDTAMKLGANHPMGPLELADFIGLDTC
LAVMQVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGRGFYDYTGETPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=44.7916666666667, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=43.1372549019608, Blast_Score=214, Evalue=5e-56,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=33.9222614840989, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=32.0689655172414, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=32.0689655172414, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI115430219, Length=238, Percent_Identity=26.890756302521, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787661, Length=287, Percent_Identity=40.7665505226481, Blast_Score=214, Evalue=4e-57,
Organism=Escherichia coli, GI1790281, Length=268, Percent_Identity=33.955223880597, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1788682, Length=259, Percent_Identity=34.3629343629344, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=43.8356164383562, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=42.0689655172414, Blast_Score=227, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.0243902439024, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=37.3665480427046, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=37.3665480427046, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=37.3665480427046, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=36.6548042704626, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=31.0344827586207, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=28.169014084507, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=35.0877192982456, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=35.0877192982456, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=35.0877192982456, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45549573, Length=247, Percent_Identity=28.3400809716599, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=26.7857142857143, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31279; Mature: 31148

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAINKIGVIGAGQMGNGIAQVCAAAGFDVILLDVSEEALKKGLGTITKNLDRALSKGKL
CCCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCC
TEAEKAATLGHIKTTTAYADFSDSDLVIEAATEDEKIKRAIFAQLCPVLKPEAHIASNTS
CHHHHHHHHCCCCHHEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHCCCCC
SLSITRLGAATDRPAKFMGMHFMNPVPVMKLVELIRGIATSEETFSLVTEMTQKLGKKAV
CEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAEDFPAFIVNRILLPMINEAVYTLYEGVGSVASIDTAMKLGANHPMGPLELADFIGLDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLAVMQVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGRGFYDYTGETPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAINKIGVIGAGQMGNGIAQVCAAAGFDVILLDVSEEALKKGLGTITKNLDRALSKGKL
CCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCC
TEAEKAATLGHIKTTTAYADFSDSDLVIEAATEDEKIKRAIFAQLCPVLKPEAHIASNTS
CHHHHHHHHCCCCHHEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHCCCCC
SLSITRLGAATDRPAKFMGMHFMNPVPVMKLVELIRGIATSEETFSLVTEMTQKLGKKAV
CEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAEDFPAFIVNRILLPMINEAVYTLYEGVGSVASIDTAMKLGANHPMGPLELADFIGLDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLAVMQVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGRGFYDYTGETPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]