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The map label for this gene is hisG

Identifier: 83312442

GI number: 83312442

Start: 3633412

End: 3634071

Strand: Reverse

Name: hisG

Synonym: amb3343

Alternate gene names: 83312442

Gene position: 3634071-3633412 (Counterclockwise)

Preceding gene: 83312444

Following gene: 83312441

Centisome position: 73.16

GC content: 66.67

Gene sequence:

>660_bases
GTGAGCCCGCAAGACAAACTGGTCATCGCCCTGCCCAAGGGCCGTATTCTCGACGAGGCCATGCCCCTGGTCCGTGCCGC
CGGCATCCTGCCGGAACCCGCCTTCGACGATCCGAAGAGCCGGCTGTTGCGCTTTGGCACCAACCATCCCCATATCGACA
TCATTCGGGTGCGCTCGTTCGACGTCGCCACGTTCGTGGCCTTCGGAGCCGCCCATCTGGGCGTGGCGGGCAACGACGTG
CTGATGGAATTCGATTACCCCGAGATCTACGCGCCCCTGGACTTAGGGATCGGTGCCTGCCGCCTGTCGGTGGCCGAGCC
CGACGATCTGGCCGCCTCGGACGATCCGCGGCGCTGGAGCCACGTGCGCATCGCCACCAAATACCCGGAAGTGACCAAGC
GCCATTTCGCGGCGCGCGGCGTCCAGGCCGAATGCGTCAAGCTCAACGGCGCCATGGAACTGGCACCGTCGCTGGGACTG
TGCACCCGCATCGTCGACCTGGTGTCGTCGGGCGCCACCCTGAAGGCCAACGGCCTGAAGGAAGTGGAGGTGCTGGCCGA
GGTGACGAGCCGCCTGATCGTCAACCGCGCCGCCCTGAAGACCCGTCCCGACGAGATGGCCGGCTGGATCGAAGCGTTTC
GCAAGGCGTGCGGAGGCTGA

Upstream 100 bases:

>100_bases
GTAACCGATGGTAACAGACGAAAGATAGTTTCTCCGCACTGGAACGGGGGCGCGAAACCGGGTAAACAGGGCTCCCCGGA
AGATATGAGTTTCAATCGCC

Downstream 100 bases:

>100_bases
TGGTGCAGAGTCTCGACTCCCGCGATTCCGGGTTCGAAGCGGCCTTCCTGGCCCTGTTGGCCATGAAGCGCGAGGTGGAC
GAGGACGTGGATCAGGCGGT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSPQDKLVIALPKGRILDEAMPLVRAAGILPEPAFDDPKSRLLRFGTNHPHIDIIRVRSFDVATFVAFGAAHLGVAGNDV
LMEFDYPEIYAPLDLGIGACRLSVAEPDDLAASDDPRRWSHVRIATKYPEVTKRHFAARGVQAECVKLNGAMELAPSLGL
CTRIVDLVSSGATLKANGLKEVEVLAEVTSRLIVNRAALKTRPDEMAGWIEAFRKACGG

Sequences:

>Translated_219_residues
MSPQDKLVIALPKGRILDEAMPLVRAAGILPEPAFDDPKSRLLRFGTNHPHIDIIRVRSFDVATFVAFGAAHLGVAGNDV
LMEFDYPEIYAPLDLGIGACRLSVAEPDDLAASDDPRRWSHVRIATKYPEVTKRHFAARGVQAECVKLNGAMELAPSLGL
CTRIVDLVSSGATLKANGLKEVEVLAEVTSRLIVNRAALKTRPDEMAGWIEAFRKACGG
>Mature_218_residues
SPQDKLVIALPKGRILDEAMPLVRAAGILPEPAFDDPKSRLLRFGTNHPHIDIIRVRSFDVATFVAFGAAHLGVAGNDVL
MEFDYPEIYAPLDLGIGACRLSVAEPDDLAASDDPRRWSHVRIATKYPEVTKRHFAARGVQAECVKLNGAMELAPSLGLC
TRIVDLVSSGATLKANGLKEVEVLAEVTSRLIVNRAALKTRPDEMAGWIEAFRKACGG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=202, Percent_Identity=39.1089108910891, Blast_Score=115, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320896, Length=199, Percent_Identity=26.6331658291457, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_MAGSA (Q2W1X8)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_422706.1
- HSSP:   Q02129
- ProteinModelPortal:   Q2W1X8
- SMR:   Q2W1X8
- STRING:   Q2W1X8
- GeneID:   3805374
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb3343
- NMPDR:   fig|342108.5.peg.2992
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q2W1X8
- ProtClustDB:   PRK01686
- BioCyc:   MMAG342108:AMB3343-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23739; Mature: 23608

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPQDKLVIALPKGRILDEAMPLVRAAGILPEPAFDDPKSRLLRFGTNHPHIDIIRVRSF
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECC
DVATFVAFGAAHLGVAGNDVLMEFDYPEIYAPLDLGIGACRLSVAEPDDLAASDDPRRWS
CHHHHHHHHHHHCCCCCCCEEEEECCCCEEECHHCCCCEEEEECCCCCCCCCCCCCCCCC
HVRIATKYPEVTKRHFAARGVQAECVKLNGAMELAPSLGLCTRIVDLVSSGATLKANGLK
EEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHCCCEEEECCCH
EVEVLAEVTSRLIVNRAALKTRPDEMAGWIEAFRKACGG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPQDKLVIALPKGRILDEAMPLVRAAGILPEPAFDDPKSRLLRFGTNHPHIDIIRVRSF
CCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECC
DVATFVAFGAAHLGVAGNDVLMEFDYPEIYAPLDLGIGACRLSVAEPDDLAASDDPRRWS
CHHHHHHHHHHHCCCCCCCEEEEECCCCEEECHHCCCCEEEEECCCCCCCCCCCCCCCCC
HVRIATKYPEVTKRHFAARGVQAECVKLNGAMELAPSLGLCTRIVDLVSSGATLKANGLK
EEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHCCCEEEECCCH
EVEVLAEVTSRLIVNRAALKTRPDEMAGWIEAFRKACGG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA