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The map label for this gene is hisD

Identifier: 83312441

GI number: 83312441

Start: 3632111

End: 3633412

Strand: Reverse

Name: hisD

Synonym: amb3342

Alternate gene names: 83312441

Gene position: 3633412-3632111 (Counterclockwise)

Preceding gene: 83312442

Following gene: 83312440

Centisome position: 73.15

GC content: 70.66

Gene sequence:

>1302_bases
ATGGTGCAGAGTCTCGACTCCCGCGATTCCGGGTTCGAAGCGGCCTTCCTGGCCCTGTTGGCCATGAAGCGCGAGGTGGA
CGAGGACGTGGATCAGGCGGTGGCCGCCATCCTGGCCGAAGTGCGCAGTCGCGGCGACGCCGCCCTGATCGAGTACACCG
CCCGTTTTGACCGGCTGGAGCTGACGCCTGCCACCCTGCGCATCACCGCGCAGGAGGTGGAGACCGCCTATGCCTCCTGC
GATCCCGAACTGATCCGTGCCCTGGAACTGGCCGCCGAGCGCATCCGCGCCTTCCACGCCCGCCAGGTGCCCGTCGACGA
TTCCTTCACCGATGCCGCCGGAGTGCGGCTGGGGCTGCGCTGGAGCCCGGTTTCCGCCGCCGGCCTGTATGTGCCGGGCG
GCACCGCCGCCTATCCCTCCTCGGTGCTGATGAACGCCATTCCCGCCAAGGCCGCCGGCGTCGAGCGTCTGGTGATGGTG
GTGCCGTCGCCCGGCGGCGTGCTCAACCCGCTGGTCCTGGCCGCCGCCAAGGTGGCGGGCGTGGACGAGATCTACCGCGT
CGGCGGCGCCCAGGCGGTGGGCGCGCTGGCCTATGGCACCGGGACCATCCGCCCGGTGGACAAGATCGTCGGCCCCGGCA
ACGCCTGGGTGGCCGCCGCCAAACGCCGGGTGTTCGGCACGGTGGGCATCGACATGATCGCCGGGCCGTCGGAAATCCTG
GTGGTGGCCGACCGCTTCAACGATCCCTCCTGGATCGCCGCCGACCTGCTGAGCCAGGCCGAGCACGATACCGCCGCGCA
AAGCATCCTGATCACCGATGACGCCGAGTTCGGCCAAAGGGTGGCGGCGGCGGTGGAGTCGCACCTGGCGACCCTGCCGC
GTGCCAAGATCGCCCGGGAAAGCTGGGACAGCCACGGCGCCATCATCGTGGTGCCCGATCTGGAGGCCTCGCTGCCGCTG
ATCGACCGCATCGCGCCCGAGCATCTGGAGCTGGCGGTGGAGAATCCCGACGCCCTGGCCGCCCGGGTGAGGAACGCCGG
CGCCATCTTCCTGGGGCGCTATACCCCCGAAGCGGTGGGCGATTATATCGGCGGTCCCAACCATGTTCTGCCCACGGCGC
GCTCGGCCCGTTTCTCCTCGGGCCTCGGCGTGCTGGACTTTATGAAGCGCACCACCCTGCTGGGCTGCGACGCGGATTCC
CTGCGGGCCATCGGCCCGGCGGCGGTGCGTCTGGCCGAGGCGGAAGGCCTCGGCGCCCACGGTCTGTCGGTGGCGTTACG
GCTCAACCTGGGGGCCGGCTGA

Upstream 100 bases:

>100_bases
AGGTGACGAGCCGCCTGATCGTCAACCGCGCCGCCCTGAAGACCCGTCCCGACGAGATGGCCGGCTGGATCGAAGCGTTT
CGCAAGGCGTGCGGAGGCTG

Downstream 100 bases:

>100_bases
TGCCGCATCGCCAGAAGCTGGCCAAGATCGAGTTGGTGGAGAAGTACCAGGTCCGCCGCGCCGCCGAGGTGGAGCACGAA
CGTGCCGTCGCCGTCTATGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MVQSLDSRDSGFEAAFLALLAMKREVDEDVDQAVAAILAEVRSRGDAALIEYTARFDRLELTPATLRITAQEVETAYASC
DPELIRALELAAERIRAFHARQVPVDDSFTDAAGVRLGLRWSPVSAAGLYVPGGTAAYPSSVLMNAIPAKAAGVERLVMV
VPSPGGVLNPLVLAAAKVAGVDEIYRVGGAQAVGALAYGTGTIRPVDKIVGPGNAWVAAAKRRVFGTVGIDMIAGPSEIL
VVADRFNDPSWIAADLLSQAEHDTAAQSILITDDAEFGQRVAAAVESHLATLPRAKIARESWDSHGAIIVVPDLEASLPL
IDRIAPEHLELAVENPDALAARVRNAGAIFLGRYTPEAVGDYIGGPNHVLPTARSARFSSGLGVLDFMKRTTLLGCDADS
LRAIGPAAVRLAEAEGLGAHGLSVALRLNLGAG

Sequences:

>Translated_433_residues
MVQSLDSRDSGFEAAFLALLAMKREVDEDVDQAVAAILAEVRSRGDAALIEYTARFDRLELTPATLRITAQEVETAYASC
DPELIRALELAAERIRAFHARQVPVDDSFTDAAGVRLGLRWSPVSAAGLYVPGGTAAYPSSVLMNAIPAKAAGVERLVMV
VPSPGGVLNPLVLAAAKVAGVDEIYRVGGAQAVGALAYGTGTIRPVDKIVGPGNAWVAAAKRRVFGTVGIDMIAGPSEIL
VVADRFNDPSWIAADLLSQAEHDTAAQSILITDDAEFGQRVAAAVESHLATLPRAKIARESWDSHGAIIVVPDLEASLPL
IDRIAPEHLELAVENPDALAARVRNAGAIFLGRYTPEAVGDYIGGPNHVLPTARSARFSSGLGVLDFMKRTTLLGCDADS
LRAIGPAAVRLAEAEGLGAHGLSVALRLNLGAG
>Mature_433_residues
MVQSLDSRDSGFEAAFLALLAMKREVDEDVDQAVAAILAEVRSRGDAALIEYTARFDRLELTPATLRITAQEVETAYASC
DPELIRALELAAERIRAFHARQVPVDDSFTDAAGVRLGLRWSPVSAAGLYVPGGTAAYPSSVLMNAIPAKAAGVERLVMV
VPSPGGVLNPLVLAAAKVAGVDEIYRVGGAQAVGALAYGTGTIRPVDKIVGPGNAWVAAAKRRVFGTVGIDMIAGPSEIL
VVADRFNDPSWIAADLLSQAEHDTAAQSILITDDAEFGQRVAAAVESHLATLPRAKIARESWDSHGAIIVVPDLEASLPL
IDRIAPEHLELAVENPDALAARVRNAGAIFLGRYTPEAVGDYIGGPNHVLPTARSARFSSGLGVLDFMKRTTLLGCDADS
LRAIGPAAVRLAEAEGLGAHGLSVALRLNLGAG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=406, Percent_Identity=42.6108374384236, Blast_Score=297, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=38.5714285714286, Blast_Score=264, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45324; Mature: 45324

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSLDSRDSGFEAAFLALLAMKREVDEDVDQAVAAILAEVRSRGDAALIEYTARFDRLE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCEE
LTPATLRITAQEVETAYASCDPELIRALELAAERIRAFHARQVPVDDSFTDAAGVRLGLR
ECCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
WSPVSAAGLYVPGGTAAYPSSVLMNAIPAKAAGVERLVMVVPSPGGVLNPLVLAAAKVAG
ECCCCCCEEECCCCCCCCCHHHHHHHCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHCC
VDEIYRVGGAQAVGALAYGTGTIRPVDKIVGPGNAWVAAAKRRVFGTVGIDMIAGPSEIL
HHHHHHCCCCHHHHHHEECCCCCCHHHHHCCCCCHHHHHHHHHHHEECCHHEECCCCEEE
VVADRFNDPSWIAADLLSQAEHDTAAQSILITDDAEFGQRVAAAVESHLATLPRAKIARE
EEEECCCCCHHHHHHHHHHHCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
SWDSHGAIIVVPDLEASLPLIDRIAPEHLELAVENPDALAARVRNAGAIFLGRYTPEAVG
CCCCCCCEEEEECCCCCCCHHHHCCCCHHEEEECCCHHHHHHHCCCCEEEEECCCHHHHH
DYIGGPNHVLPTARSARFSSGLGVLDFMKRTTLLGCDADSLRAIGPAAVRLAEAEGLGAH
HHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEECCCHHHHHHCCHHHHEEECCCCCCCC
GLSVALRLNLGAG
CEEEEEEEECCCC
>Mature Secondary Structure
MVQSLDSRDSGFEAAFLALLAMKREVDEDVDQAVAAILAEVRSRGDAALIEYTARFDRLE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCEE
LTPATLRITAQEVETAYASCDPELIRALELAAERIRAFHARQVPVDDSFTDAAGVRLGLR
ECCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
WSPVSAAGLYVPGGTAAYPSSVLMNAIPAKAAGVERLVMVVPSPGGVLNPLVLAAAKVAG
ECCCCCCEEECCCCCCCCCHHHHHHHCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHCC
VDEIYRVGGAQAVGALAYGTGTIRPVDKIVGPGNAWVAAAKRRVFGTVGIDMIAGPSEIL
HHHHHHCCCCHHHHHHEECCCCCCHHHHHCCCCCHHHHHHHHHHHEECCHHEECCCCEEE
VVADRFNDPSWIAADLLSQAEHDTAAQSILITDDAEFGQRVAAAVESHLATLPRAKIARE
EEEECCCCCHHHHHHHHHHHCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
SWDSHGAIIVVPDLEASLPLIDRIAPEHLELAVENPDALAARVRNAGAIFLGRYTPEAVG
CCCCCCCEEEEECCCCCCCHHHHCCCCHHEEEECCCHHHHHHHCCCCEEEEECCCHHHHH
DYIGGPNHVLPTARSARFSSGLGVLDFMKRTTLLGCDADSLRAIGPAAVRLAEAEGLGAH
HHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEECCCHHHHHHCCHHHHEEECCCCCCCC
GLSVALRLNLGAG
CEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA