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The map label for this gene is pyrH

Identifier: 83311595

GI number: 83311595

Start: 2673394

End: 2674116

Strand: Reverse

Name: pyrH

Synonym: amb2496

Alternate gene names: 83311595

Gene position: 2674116-2673394 (Counterclockwise)

Preceding gene: 83311596

Following gene: 83311594

Centisome position: 53.84

GC content: 64.45

Gene sequence:

>723_bases
ATGGCCAGCGACGCCAAATTCCGCCGCGTTCTCCTCAAGATTTCGGGCGAAGGCCTGATGGGAACGCGGGAGTATGGACT
TGATCCCGAGACCGTCGATCGCATCGCTCGCGAGGTGAAGTCCGTCCGCGACCTCGGCGTCGAGGTCTGCGTGGTCATCG
GCGGCGGTAATATCTTCCGTGGCGTATCGGGCGCCTCGTCCGGCATGGAGCGGGCCGCGGCCGACAACATGGGCATGCTG
GCCACCGTCATCAACGCGCTGTCGGTGCAGAATGCCCTGGAGAAGGTGGGCGTCGAGACCCGCGTGCAGTCGGCCATCGT
CATGCCGACCGTGTGCGAGGCCTTCATCCGCCGCCGCGCCATCCGTCATCTGGAAAAGGGCAGGGTGGTGATTTTCGCCG
CCGGAACCGGCAATCCGTTCTTCACCACCGATACCGCCGCCGCGCTTCGCGCCGTCGAAATGGGCTGTGACGCCCTTTTG
AAGGCCACCCAGGTGGATGGCGTGTATTCCGCCGACCCCAAGAAGGTCAAGGACGCGGTCCGCTATGACCGCCTGACCTT
CAACGAGGTTCTGGCCCGCGACCTAGCCGTGATGGACACCTCCGCCATCGCCTTGTGTCGCGAGAACAAAGTTCCCATCG
TGGTGTTCGACCTGCACCGGCCCGGCGCCTTCGCCGAAACGGTCTCGGGACGCGGCCTGTTCACCATCATCGCCAACGAC
TAA

Upstream 100 bases:

>100_bases
TTTTCTCTCCACAAGGGGGGAGACAGGCGGGTGGAATGGTGTATGATCGCCGCCGCCCGCGCCAAGCATCTTGGCAAAAC
TTTCCAATTCGAGGGAGCCC

Downstream 100 bases:

>100_bases
TAAGCCTTAAGGGGAGTCGATCGTGTCCGCTCCGACCAACTGGAACGACCTCAAGAAGGACATCACCCGGCGCATGGACA
GTGCCGTCGAGGTGCTGAAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MASDAKFRRVLLKISGEGLMGTREYGLDPETVDRIAREVKSVRDLGVEVCVVIGGGNIFRGVSGASSGMERAAADNMGML
ATVINALSVQNALEKVGVETRVQSAIVMPTVCEAFIRRRAIRHLEKGRVVIFAAGTGNPFFTTDTAAALRAVEMGCDALL
KATQVDGVYSADPKKVKDAVRYDRLTFNEVLARDLAVMDTSAIALCRENKVPIVVFDLHRPGAFAETVSGRGLFTIIAND

Sequences:

>Translated_240_residues
MASDAKFRRVLLKISGEGLMGTREYGLDPETVDRIAREVKSVRDLGVEVCVVIGGGNIFRGVSGASSGMERAAADNMGML
ATVINALSVQNALEKVGVETRVQSAIVMPTVCEAFIRRRAIRHLEKGRVVIFAAGTGNPFFTTDTAAALRAVEMGCDALL
KATQVDGVYSADPKKVKDAVRYDRLTFNEVLARDLAVMDTSAIALCRENKVPIVVFDLHRPGAFAETVSGRGLFTIIAND
>Mature_239_residues
ASDAKFRRVLLKISGEGLMGTREYGLDPETVDRIAREVKSVRDLGVEVCVVIGGGNIFRGVSGASSGMERAAADNMGMLA
TVINALSVQNALEKVGVETRVQSAIVMPTVCEAFIRRRAIRHLEKGRVVIFAAGTGNPFFTTDTAAALRAVEMGCDALLK
ATQVDGVYSADPKKVKDAVRYDRLTFNEVLARDLAVMDTSAIALCRENKVPIVVFDLHRPGAFAETVSGRGLFTIIAND

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=49.7907949790795, Blast_Score=242, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MAGSA (Q2W4C5)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_421859.1
- HSSP:   P65938
- ProteinModelPortal:   Q2W4C5
- SMR:   Q2W4C5
- STRING:   Q2W4C5
- GeneID:   3803213
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb2496
- NMPDR:   fig|342108.5.peg.2196
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2W4C5
- ProtClustDB:   PRK00358
- BioCyc:   MMAG342108:AMB2496-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25778; Mature: 25647

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 75-75 BINDING 163-163 BINDING 164-164 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDAKFRRVLLKISGEGLMGTREYGLDPETVDRIAREVKSVRDLGVEVCVVIGGGNIFR
CCCCHHHHHHHEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
GVSGASSGMERAAADNMGMLATVINALSVQNALEKVGVETRVQSAIVMPTVCEAFIRRRA
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IRHLEKGRVVIFAAGTGNPFFTTDTAAALRAVEMGCDALLKATQVDGVYSADPKKVKDAV
HHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RYDRLTFNEVLARDLAVMDTSAIALCRENKVPIVVFDLHRPGAFAETVSGRGLFTIIAND
HHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCEEEEEEECC
>Mature Secondary Structure 
ASDAKFRRVLLKISGEGLMGTREYGLDPETVDRIAREVKSVRDLGVEVCVVIGGGNIFR
CCCHHHHHHHEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
GVSGASSGMERAAADNMGMLATVINALSVQNALEKVGVETRVQSAIVMPTVCEAFIRRRA
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IRHLEKGRVVIFAAGTGNPFFTTDTAAALRAVEMGCDALLKATQVDGVYSADPKKVKDAV
HHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RYDRLTFNEVLARDLAVMDTSAIALCRENKVPIVVFDLHRPGAFAETVSGRGLFTIIAND
HHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA