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The map label for this gene is dacC [H]

Identifier: 83311550

GI number: 83311550

Start: 2627277

End: 2628443

Strand: Reverse

Name: dacC [H]

Synonym: amb2451

Alternate gene names: 83311550

Gene position: 2628443-2627277 (Counterclockwise)

Preceding gene: 83311551

Following gene: 83311549

Centisome position: 52.92

GC content: 64.7

Gene sequence:

>1167_bases
GTGATGCTCGCTCTCTTCCGCCGTTCCCTGGCCGCGGCCCTGGCCGTTCCCCTGATGGCCCTTTCGGCCACGGCCGGGGC
TCAATCCATCGAGACCGCCGCCAAGCAGGCGATCATCATCGACTATGCCAGCGGCCAGGTGCTGATGGAGAAGAACGCCG
ATGAGCTGATGGTGCCCAGTTCCATGAGCAAGCTGATGACCGTGTTCATGGTCTTCGACAAGCTCAAGACCGGCGCCTGG
AAGCCCTCGGACCGGCTGCCGGTCAGCGAGACCGCCTGGAAGCGGCACTACAAGTCCGAAGGCTCGCTGATGTTCCTGCC
CGTCAATTCCACGGCCACGGTCGAGGAATTGCTGAAGGGCGTGGTGATCCAGTCCGGCAACGACGCCTGCTCGGTGCTGG
CCGAGGCCCATTCCGGCTCGGAGGAAGCCTTCGCCGAGGAGGAAACCCGCCGAGCCCGGCAGATCGGCCTGACCCGGAGC
GTCTTCAAGAATGCCAGCGGCTGGCCCGAGCCCGGTCACCTGATGACGGCCCGCGACCTGTCGGTACTGGCCCGCCACCT
GATCGCCGATTTCCCTGAATACTATCCGCTGTTCAGCCAGATGGAATTCGTGTTCAACGGCATCAAGCAGGGCAACCGCA
ATCCGCTGCTGTACAACACGCCAGGCGCCGACGGGCTCAAGACCGGCCATACCGAGGCCGCCGGCTATGGCCTGACCGCA
TCCATCAAGCGGGGCAACCGCCGCATCATCATGATTCTGAACGGCATGTCCTCCATGAAGGAGCGGGCCGAGGAATCGCG
GCGCCTGACCGAATGGGCCTTCCGCGAGTGGGAGACCTACGCCCTGTTCAAGGCGGGCGAGGAGGTCATCCCCGATGCCG
AGGTCTGGCTGGGCCAGAAGGAAACCGTGCCGCTGCTGATCAAGGACAGCCTGGAAGTCAGCATGCAGCGGCGCAACCGC
CTCGAGATGAAGGTCACGACCGTCTATAACGGCCCCATCGCCGCCCCGGTCAAGGCTGGGCAGGAAGTGGGCAAGGTGGT
GGTGACGGCTCCCGGCATGGCGCCTGTCGAGGTTCCCATGGTGGCCGGTGCCGACGTGGAGAAGCTGGGCTTTGCCGGGC
GCATGTCCACCGCCTTCAAGCGCGTCATCTGGGGCAAGAAGGGTTAA

Upstream 100 bases:

>100_bases
CATGACCAGCGTCGAGGAGGCCGACCGCGTCCTCGATTCCGTGGTCGCCACGGGGGCGGAAGACGCCCGCGTGGTTGTTG
ATTAACAAAGAAAAGGCGCC

Downstream 100 bases:

>100_bases
CAGGCATGGAGACAGCTCGCGGACGCTTCATCACCTTCGAGGGCGGAGAAGGCGCGGGCAAATCCACCCAGGTCCGACTG
CTGGCGGAATCCCTGCGCGA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MMLALFRRSLAAALAVPLMALSATAGAQSIETAAKQAIIIDYASGQVLMEKNADELMVPSSMSKLMTVFMVFDKLKTGAW
KPSDRLPVSETAWKRHYKSEGSLMFLPVNSTATVEELLKGVVIQSGNDACSVLAEAHSGSEEAFAEEETRRARQIGLTRS
VFKNASGWPEPGHLMTARDLSVLARHLIADFPEYYPLFSQMEFVFNGIKQGNRNPLLYNTPGADGLKTGHTEAAGYGLTA
SIKRGNRRIIMILNGMSSMKERAEESRRLTEWAFREWETYALFKAGEEVIPDAEVWLGQKETVPLLIKDSLEVSMQRRNR
LEMKVTTVYNGPIAAPVKAGQEVGKVVVTAPGMAPVEVPMVAGADVEKLGFAGRMSTAFKRVIWGKKG

Sequences:

>Translated_388_residues
MMLALFRRSLAAALAVPLMALSATAGAQSIETAAKQAIIIDYASGQVLMEKNADELMVPSSMSKLMTVFMVFDKLKTGAW
KPSDRLPVSETAWKRHYKSEGSLMFLPVNSTATVEELLKGVVIQSGNDACSVLAEAHSGSEEAFAEEETRRARQIGLTRS
VFKNASGWPEPGHLMTARDLSVLARHLIADFPEYYPLFSQMEFVFNGIKQGNRNPLLYNTPGADGLKTGHTEAAGYGLTA
SIKRGNRRIIMILNGMSSMKERAEESRRLTEWAFREWETYALFKAGEEVIPDAEVWLGQKETVPLLIKDSLEVSMQRRNR
LEMKVTTVYNGPIAAPVKAGQEVGKVVVTAPGMAPVEVPMVAGADVEKLGFAGRMSTAFKRVIWGKKG
>Mature_388_residues
MMLALFRRSLAAALAVPLMALSATAGAQSIETAAKQAIIIDYASGQVLMEKNADELMVPSSMSKLMTVFMVFDKLKTGAW
KPSDRLPVSETAWKRHYKSEGSLMFLPVNSTATVEELLKGVVIQSGNDACSVLAEAHSGSEEAFAEEETRRARQIGLTRS
VFKNASGWPEPGHLMTARDLSVLARHLIADFPEYYPLFSQMEFVFNGIKQGNRNPLLYNTPGADGLKTGHTEAAGYGLTA
SIKRGNRRIIMILNGMSSMKERAEESRRLTEWAFREWETYALFKAGEEVIPDAEVWLGQKETVPLLIKDSLEVSMQRRNR
LEMKVTTVYNGPIAAPVKAGQEVGKVVVTAPGMAPVEVPMVAGADVEKLGFAGRMSTAFKRVIWGKKG

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=381, Percent_Identity=38.0577427821522, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1786851, Length=377, Percent_Identity=33.6870026525199, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082022, Length=386, Percent_Identity=31.3471502590674, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI87082054, Length=289, Percent_Identity=26.643598615917, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42564; Mature: 42564

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLALFRRSLAAALAVPLMALSATAGAQSIETAAKQAIIIDYASGQVLMEKNADELMVPS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCCEEEEECCCCCEECCH
SMSKLMTVFMVFDKLKTGAWKPSDRLPVSETAWKRHYKSEGSLMFLPVNSTATVEELLKG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
VVIQSGNDACSVLAEAHSGSEEAFAEEETRRARQIGLTRSVFKNASGWPEPGHLMTARDL
HEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCEEEHHHH
SVLARHLIADFPEYYPLFSQMEFVFNGIKQGNRNPLLYNTPGADGLKTGHTEAAGYGLTA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEE
SIKRGNRRIIMILNGMSSMKERAEESRRLTEWAFREWETYALFKAGEEVIPDAEVWLGQK
EEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCC
ETVPLLIKDSLEVSMQRRNRLEMKVTTVYNGPIAAPVKAGQEVGKVVVTAPGMAPVEVPM
CCCCEEEECHHHHHHHHCCCEEEEEEEEECCCCCCHHHCCHHHCEEEEECCCCCCEEECE
VAGADVEKLGFAGRMSTAFKRVIWGKKG
ECCCCHHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMLALFRRSLAAALAVPLMALSATAGAQSIETAAKQAIIIDYASGQVLMEKNADELMVPS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCCEEEEECCCCCEECCH
SMSKLMTVFMVFDKLKTGAWKPSDRLPVSETAWKRHYKSEGSLMFLPVNSTATVEELLKG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
VVIQSGNDACSVLAEAHSGSEEAFAEEETRRARQIGLTRSVFKNASGWPEPGHLMTARDL
HEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCEEEHHHH
SVLARHLIADFPEYYPLFSQMEFVFNGIKQGNRNPLLYNTPGADGLKTGHTEAAGYGLTA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEE
SIKRGNRRIIMILNGMSSMKERAEESRRLTEWAFREWETYALFKAGEEVIPDAEVWLGQK
EEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCC
ETVPLLIKDSLEVSMQRRNRLEMKVTTVYNGPIAAPVKAGQEVGKVVVTAPGMAPVEVPM
CCCCEEEECHHHHHHHHCCCEEEEEEEEECCCCCCHHHCCHHHCEEEEECCCCCCEEECE
VAGADVEKLGFAGRMSTAFKRVIWGKKG
ECCCCHHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]