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The map label for this gene is menB [H]

Identifier: 83311242

GI number: 83311242

Start: 2319337

End: 2320470

Strand: Reverse

Name: menB [H]

Synonym: amb2143

Alternate gene names: 83311242

Gene position: 2320470-2319337 (Counterclockwise)

Preceding gene: 83311243

Following gene: 83311241

Centisome position: 46.72

GC content: 64.99

Gene sequence:

>1134_bases
ATGAAGAAGGAAACCGCGGCCATCGTCGATTCAACGGCGCCCGCCCACCTCAACGATCACAATCTGGTCCCCACCACCGT
GGTCCCCGGCGTTCTGTACGAGAAGCGCCCGGCCAAGCGGGCCGACGGCACCGTGGCCGAGGGCCTGTATAACGCCTGGA
TCACGCTGGACAACCAGAAGCAGTACAATTCCTACACCACCGACATGGTGAAGGGCGTCATCATGGCGTTCCGCGACGCC
TCCAACGCCCGCGACGTGTCGTCGGTGGTGTTTACCGGCGCCGGCGACAAGGCGTTCTGCACCGGCGGCAACACCAAGGA
ATATGCCGAGTACTACGCCGGCAACCCGCAGGAATACCGCCAGTACATGCGGCTGTTCAACGACATGGTCTCGGCCATCC
TGGGCTGCGACAAGCCGGTGATCTGCCGCGTCAACGGCATGCGCATCGGCGGCGGCCAGGAAATCGGCATGGCCGCCGAC
TTCTCGGTGGCCCAGGATCTGGCCAAGTTCGGTCAGGCCGGCCCCAAGCACGGCTCGGCCCCCATCGGCGGCGCCACCGA
CTTCCTGCCCGTCATGATCGGCTGCGAGCAGGCCATGGTGTCGGGTTCGCTCTGCGAGCCCTGGTCGGCCCACAAGGCCT
ATCGCACCGGCATCATCATGGATCTGGTCCCGGCCCTGAAGGTCGACGGCAAGTTCGTCGCCAACCCCCTGGTGATCACC
GACCGCTATCTCGACGAGTTCGGCAAGATCGTCCACGGCGAGTCCAAGACCGGCGCCGAGCTGGCAGCGGGCAAGGAGCT
GCTGAAGAAGGGCACCATCGACCTGTCCCTGCTGGACGCCAAGGTCGAGGAGATCTGCGCCAAGATCCTGCACACCTTCC
CGGATTGCTTCACCAAGACGATCCAGGAACTGCGCAAGCCCAAGCTGAACGCCTGGAACGCCAACAAGGAAAACAGCCGC
GACTGGCTGGGCCTCAACATGATGACCGAGGCCCGCACCGGCTTCCGCGCCTTCAACGAGGGTCCCAAGGAAGACCGCGA
GATCGACTTCGTGGCGCTCCGCCAGGCCCTGGCCAAGGGTGCCCCGTGGACGCCCGAGCTGATCGAGTCCCTGATCCCCA
AGGCGGGCCACTGA

Upstream 100 bases:

>100_bases
CAACGACACGTTCGCCGCCGTGCACGACCACAAGCTGTCGCGCCGCGCCGTCCTGTGCCCCAACGCCTAAAAGAAATTCA
AGAGAGGGAGAGTCCTGGTC

Downstream 100 bases:

>100_bases
CATGGCCGAAGGCATCTCCAACTGCCTGAAGGTCTGGAAGGACCGCGAGGGGAAGCTGCTGCGGCTGCGCCTCTCGCGGC
CCAAGGCCAACATCGTCGAC

Product: dihydroxynaphthoic acid synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKKETAAIVDSTAPAHLNDHNLVPTTVVPGVLYEKRPAKRADGTVAEGLYNAWITLDNQKQYNSYTTDMVKGVIMAFRDA
SNARDVSSVVFTGAGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAAD
FSVAQDLAKFGQAGPKHGSAPIGGATDFLPVMIGCEQAMVSGSLCEPWSAHKAYRTGIIMDLVPALKVDGKFVANPLVIT
DRYLDEFGKIVHGESKTGAELAAGKELLKKGTIDLSLLDAKVEEICAKILHTFPDCFTKTIQELRKPKLNAWNANKENSR
DWLGLNMMTEARTGFRAFNEGPKEDREIDFVALRQALAKGAPWTPELIESLIPKAGH

Sequences:

>Translated_377_residues
MKKETAAIVDSTAPAHLNDHNLVPTTVVPGVLYEKRPAKRADGTVAEGLYNAWITLDNQKQYNSYTTDMVKGVIMAFRDA
SNARDVSSVVFTGAGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAAD
FSVAQDLAKFGQAGPKHGSAPIGGATDFLPVMIGCEQAMVSGSLCEPWSAHKAYRTGIIMDLVPALKVDGKFVANPLVIT
DRYLDEFGKIVHGESKTGAELAAGKELLKKGTIDLSLLDAKVEEICAKILHTFPDCFTKTIQELRKPKLNAWNANKENSR
DWLGLNMMTEARTGFRAFNEGPKEDREIDFVALRQALAKGAPWTPELIESLIPKAGH
>Mature_377_residues
MKKETAAIVDSTAPAHLNDHNLVPTTVVPGVLYEKRPAKRADGTVAEGLYNAWITLDNQKQYNSYTTDMVKGVIMAFRDA
SNARDVSSVVFTGAGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAAD
FSVAQDLAKFGQAGPKHGSAPIGGATDFLPVMIGCEQAMVSGSLCEPWSAHKAYRTGIIMDLVPALKVDGKFVANPLVIT
DRYLDEFGKIVHGESKTGAELAAGKELLKKGTIDLSLLDAKVEEICAKILHTFPDCFTKTIQELRKPKLNAWNANKENSR
DWLGLNMMTEARTGFRAFNEGPKEDREIDFVALRQALAKGAPWTPELIESLIPKAGH

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Escherichia coli, GI1788597, Length=173, Percent_Identity=33.5260115606936, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI221142681, Length=180, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=175, Percent_Identity=24.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20129971, Length=189, Percent_Identity=32.2751322751323, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653477, Length=189, Percent_Identity=32.2751322751323, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 41114; Mature: 41114

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKETAAIVDSTAPAHLNDHNLVPTTVVPGVLYEKRPAKRADGTVAEGLYNAWITLDNQK
CCCCHHHHHCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCCCHHHHHHHEEEEEECCCH
QYNSYTTDMVKGVIMAFRDASNARDVSSVVFTGAGDKAFCTGGNTKEYAEYYAGNPQEYR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCEEECCCCHHHHHHHHCCCHHHHH
QYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAADFSVAQDLAKFGQAGPKHGSA
HHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PIGGATDFLPVMIGCEQAMVSGSLCEPWSAHKAYRTGIIMDLVPALKVDGKFVANPLVIT
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEH
DRYLDEFGKIVHGESKTGAELAAGKELLKKGTIDLSLLDAKVEEICAKILHTFPDCFTKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQELRKPKLNAWNANKENSRDWLGLNMMTEARTGFRAFNEGPKEDREIDFVALRQALAKG
HHHHHCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
APWTPELIESLIPKAGH
CCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKKETAAIVDSTAPAHLNDHNLVPTTVVPGVLYEKRPAKRADGTVAEGLYNAWITLDNQK
CCCCHHHHHCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCCCHHHHHHHEEEEEECCCH
QYNSYTTDMVKGVIMAFRDASNARDVSSVVFTGAGDKAFCTGGNTKEYAEYYAGNPQEYR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCEEECCCCHHHHHHHHCCCHHHHH
QYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAADFSVAQDLAKFGQAGPKHGSA
HHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PIGGATDFLPVMIGCEQAMVSGSLCEPWSAHKAYRTGIIMDLVPALKVDGKFVANPLVIT
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEH
DRYLDEFGKIVHGESKTGAELAAGKELLKKGTIDLSLLDAKVEEICAKILHTFPDCFTKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQELRKPKLNAWNANKENSRDWLGLNMMTEARTGFRAFNEGPKEDREIDFVALRQALAKG
HHHHHCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
APWTPELIESLIPKAGH
CCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]