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The map label for this gene is dch [H]

Identifier: 83311241

GI number: 83311241

Start: 2318556

End: 2319335

Strand: Reverse

Name: dch [H]

Synonym: amb2142

Alternate gene names: 83311241

Gene position: 2319335-2318556 (Counterclockwise)

Preceding gene: 83311242

Following gene: 83311240

Centisome position: 46.69

GC content: 68.33

Gene sequence:

>780_bases
ATGGCCGAAGGCATCTCCAACTGCCTGAAGGTCTGGAAGGACCGCGAGGGGAAGCTGCTGCGGCTGCGCCTCTCGCGGCC
CAAGGCCAACATCGTCGACGCCGAGATGATCGCGGCGCTGAGCGCGGCCCTGGGCGACGCCCATGAGGATTCCGCGCTCC
GCGCCGTGCTGATCGACCACGAAGGGCCGCATTTCAGCTTCGGCGCCTCGGTGGCCGAGCACATGCCCGACCAGTGCGCC
GCCATGCTGGCCAGCCTGCACAAGCTGGTCATCGCCATGGTCGACTTCCCCCTGCCCATCCTGGTCGCCGTGCGCGGCCA
GTGCTTAGGCGGCGGGCTCGAAGTCGCCCTGGCCGGACACATGATGTTCGTCTCGCCCGACGCCAAGCTGGGCCAGCCGG
AGATCGTGCTGGGGGTGTTCGCCCCCGCCGCCTCGTGCCTGCTGCCCGAGCGCATGCCCCGGGTGGCGGCCGAGGACCTG
CTCTATTCCGGCCGTTCCATCGACGGCGCCGAGGCCGCCCGCCTCGGCATCGCCAACGCCGTGGTGGACGACCCGGAAAA
TGCCGCCCTGGCCTGGTTCGACAACGGCCCGGCCAAGCATTCGGCGGCAAGCCTGCGTTTCGCGGTCAAGGCCGCCCGTC
TCGGCATGAACGAGCGGGTCAAGGCCAAGATCGCCGAAGTTGAAGCCCTTTACCTCAACGGCCTGATGGCCACCCACGAC
GCAGTCGAGGGTTTGAACGCCTTTCTCGAAAAGAGGCCGGCACTTTGGGAGGACCGATAG

Upstream 100 bases:

>100_bases
CGCGAGATCGACTTCGTGGCGCTCCGCCAGGCCCTGGCCAAGGGTGCCCCGTGGACGCCCGAGCTGATCGAGTCCCTGAT
CCCCAAGGCGGGCCACTGAC

Downstream 100 bases:

>100_bases
GATGTCTGGAAAGAATAAAAGCGTCGCCGACATCATGGCCGTGTGCCAGGAGATGTTCGAAGACCTGAACTTCACCTATG
CTCGCAAGTGGAAGGACGCC

Product: Cyclohexa-1,5-dienecarbonyl-CoA hydratase

Products: NA

Alternate protein names: Cyclohexa-1,5-diene-1-carboxyl-CoA hydratase; Dienoyl-CoA hydratase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAEGISNCLKVWKDREGKLLRLRLSRPKANIVDAEMIAALSAALGDAHEDSALRAVLIDHEGPHFSFGASVAEHMPDQCA
AMLASLHKLVIAMVDFPLPILVAVRGQCLGGGLEVALAGHMMFVSPDAKLGQPEIVLGVFAPAASCLLPERMPRVAAEDL
LYSGRSIDGAEAARLGIANAVVDDPENAALAWFDNGPAKHSAASLRFAVKAARLGMNERVKAKIAEVEALYLNGLMATHD
AVEGLNAFLEKRPALWEDR

Sequences:

>Translated_259_residues
MAEGISNCLKVWKDREGKLLRLRLSRPKANIVDAEMIAALSAALGDAHEDSALRAVLIDHEGPHFSFGASVAEHMPDQCA
AMLASLHKLVIAMVDFPLPILVAVRGQCLGGGLEVALAGHMMFVSPDAKLGQPEIVLGVFAPAASCLLPERMPRVAAEDL
LYSGRSIDGAEAARLGIANAVVDDPENAALAWFDNGPAKHSAASLRFAVKAARLGMNERVKAKIAEVEALYLNGLMATHD
AVEGLNAFLEKRPALWEDR
>Mature_258_residues
AEGISNCLKVWKDREGKLLRLRLSRPKANIVDAEMIAALSAALGDAHEDSALRAVLIDHEGPHFSFGASVAEHMPDQCAA
MLASLHKLVIAMVDFPLPILVAVRGQCLGGGLEVALAGHMMFVSPDAKLGQPEIVLGVFAPAASCLLPERMPRVAAEDLL
YSGRSIDGAEAARLGIANAVVDDPENAALAWFDNGPAKHSAASLRFAVKAARLGMNERVKAKIAEVEALYLNGLMATHDA
VEGLNAFLEKRPALWEDR

Specific function: Catalyzes the hydration of cyclohexa-1,5-diene-1- carboxyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI68989263, Length=173, Percent_Identity=31.2138728323699, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI31542718, Length=241, Percent_Identity=24.4813278008299, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI20127408, Length=181, Percent_Identity=28.1767955801105, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI221142681, Length=262, Percent_Identity=27.4809160305344, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=28.968253968254, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790281, Length=163, Percent_Identity=27.6073619631902, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788682, Length=173, Percent_Identity=29.4797687861272, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=243, Percent_Identity=25.1028806584362, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24653139, Length=256, Percent_Identity=29.6875, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129971, Length=248, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653477, Length=248, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR017602 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.100 [H]

Molecular weight: Translated: 27601; Mature: 27470

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGISNCLKVWKDREGKLLRLRLSRPKANIVDAEMIAALSAALGDAHEDSALRAVLIDH
CCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
EGPHFSFGASVAEHMPDQCAAMLASLHKLVIAMVDFPLPILVAVRGQCLGGGLEVALAGH
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHCCCCEEEEEECE
MMFVSPDAKLGQPEIVLGVFAPAASCLLPERMPRVAAEDLLYSGRSIDGAEAARLGIANA
EEEECCCCCCCCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VVDDPENAALAWFDNGPAKHSAASLRFAVKAARLGMNERVKAKIAEVEALYLNGLMATHD
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHH
AVEGLNAFLEKRPALWEDR
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AEGISNCLKVWKDREGKLLRLRLSRPKANIVDAEMIAALSAALGDAHEDSALRAVLIDH
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
EGPHFSFGASVAEHMPDQCAAMLASLHKLVIAMVDFPLPILVAVRGQCLGGGLEVALAGH
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHCCCCEEEEEECE
MMFVSPDAKLGQPEIVLGVFAPAASCLLPERMPRVAAEDLLYSGRSIDGAEAARLGIANA
EEEECCCCCCCCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VVDDPENAALAWFDNGPAKHSAASLRFAVKAARLGMNERVKAKIAEVEALYLNGLMATHD
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHH
AVEGLNAFLEKRPALWEDR
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9746358; 9738901 [H]