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The map label for this gene is hemA [H]

Identifier: 83310782

GI number: 83310782

Start: 1823112

End: 1824350

Strand: Reverse

Name: hemA [H]

Synonym: amb1683

Alternate gene names: 83310782

Gene position: 1824350-1823112 (Counterclockwise)

Preceding gene: 83310783

Following gene: 83310780

Centisome position: 36.73

GC content: 65.78

Gene sequence:

>1239_bases
ATGGATTACGAGCATTACTTCACCAAGCGGATCAGCGACCTCAAGTCCGAGGGGCGCTATCGGGTGTTCGCCGATCTGGA
ACGCCAGAAGGGCCGCTTCCCCATCGCCCTCAACTATCGCGACGGCGAAGTGCGCGAAGTGGTGGTGTGGTGCTCCAACG
ATTATCTCGGCATGGGCCAGCACCCGGAGGTGATCGCCGCCGCCCACGAGGCGCTGGAGCGCTGCGGCGCCGGCGCCGGC
GGCACCCGCAACATTTCCGGCACCAACCATTATCACGTGCTGCTGGAAGAGGAGCTGGCCAGCTTCAACGCCAAGGAATC
GTCGCTGCTGTTCACCTCGGGCTACGTGGCCAACCAGACTACGCTCTCCACCCTGGGCGCCACCATTCCGGGCTGCGTGG
TGTTCTCCGACGAGCTCAACCATAATTCCATGATCGAAGGCATTCGCCACGGCCGCTCGGCCAAGCAGGTCTTCCGTCAC
AACGACCCCGAGCACCTGGAACAGTTGCTGTCGGCCTATCCGAAGGAGACGCCCAAGCTGGTGGCCTTCGAGTCGGTCTA
TTCCATGGACGGCGACATCGCCCCCATCGCCGAGATCTGCGACGTGGCCGAGGCCCACAACGCCATGACCTATCTGGACG
AGGTCCACGCGGTCGGCATGTATGGCGCCGAAGGGTCCGGCGTGGCCGAGCGCGACGGGGTGCGCGACCGCATCACCATC
ATCCAGGGGACCCTGGCCAAGGCGCTGGGCGTGGTGGGCGGCTATATCGCCGCCTCGGCCTCCTGCGTCGACTATGTCCG
CAGCTTCGGCCCCGGCTTCATCTTCTCGTCGTCCATGCCGCCGGCCACCGCCGCCGCCGCCCTGGCCTCCATCCGGTACT
TGCGCGCCCATCCGGAGATCCGCGACCGGCACCAGGAGCGCGCCGCCACGGCCAAGCGCCTGCTGAGCGCACGGGGCATT
CCCGTGCTGCCCTCGGTCAGCCACATCGTGCCGGTAATGGTGGGCAACGCCGCCCTGTGCAAGGAAGCCAGCGACCTGCT
GCTCAACGAGTACGGCATCTATGTCCAGCCCATCAATTACCCCACCGTTCCCGTGGGAACCGAGCGGCTGCGCATTACGC
CGACGCCGCTGCACGACGATGCCATGATGGCCCATCTGGTGGACGCCTTCTCGGCGGTGTGGGACCGGTTGGACCTGCAC
AAGGTCCACCACCCGAAAACCATCAAGGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
GCTTGTACACTTGCGCCCCGGCTTTTCGATCCTCTAGGATCGGCGCACCGGCCCGAGACCCCGGAAAACACGGGGCCTGA
CGGGTCGAGGGAGGAGAGGA

Downstream 100 bases:

>100_bases
CGACAGCTTTTTGTCAGGCTGAGGCCGTACCCTGAATCAAGTCGAGCCGAATCGCTCCGGCATGCCCTCGTTGGAGCAAT
CGTTCGGTTTGGCCCTCCCA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDYEHYFTKRISDLKSEGRYRVFADLERQKGRFPIALNYRDGEVREVVVWCSNDYLGMGQHPEVIAAAHEALERCGAGAG
GTRNISGTNHYHVLLEEELASFNAKESSLLFTSGYVANQTTLSTLGATIPGCVVFSDELNHNSMIEGIRHGRSAKQVFRH
NDPEHLEQLLSAYPKETPKLVAFESVYSMDGDIAPIAEICDVAEAHNAMTYLDEVHAVGMYGAEGSGVAERDGVRDRITI
IQGTLAKALGVVGGYIAASASCVDYVRSFGPGFIFSSSMPPATAAAALASIRYLRAHPEIRDRHQERAATAKRLLSARGI
PVLPSVSHIVPVMVGNAALCKEASDLLLNEYGIYVQPINYPTVPVGTERLRITPTPLHDDAMMAHLVDAFSAVWDRLDLH
KVHHPKTIKAAE

Sequences:

>Translated_412_residues
MDYEHYFTKRISDLKSEGRYRVFADLERQKGRFPIALNYRDGEVREVVVWCSNDYLGMGQHPEVIAAAHEALERCGAGAG
GTRNISGTNHYHVLLEEELASFNAKESSLLFTSGYVANQTTLSTLGATIPGCVVFSDELNHNSMIEGIRHGRSAKQVFRH
NDPEHLEQLLSAYPKETPKLVAFESVYSMDGDIAPIAEICDVAEAHNAMTYLDEVHAVGMYGAEGSGVAERDGVRDRITI
IQGTLAKALGVVGGYIAASASCVDYVRSFGPGFIFSSSMPPATAAAALASIRYLRAHPEIRDRHQERAATAKRLLSARGI
PVLPSVSHIVPVMVGNAALCKEASDLLLNEYGIYVQPINYPTVPVGTERLRITPTPLHDDAMMAHLVDAFSAVWDRLDLH
KVHHPKTIKAAE
>Mature_412_residues
MDYEHYFTKRISDLKSEGRYRVFADLERQKGRFPIALNYRDGEVREVVVWCSNDYLGMGQHPEVIAAAHEALERCGAGAG
GTRNISGTNHYHVLLEEELASFNAKESSLLFTSGYVANQTTLSTLGATIPGCVVFSDELNHNSMIEGIRHGRSAKQVFRH
NDPEHLEQLLSAYPKETPKLVAFESVYSMDGDIAPIAEICDVAEAHNAMTYLDEVHAVGMYGAEGSGVAERDGVRDRITI
IQGTLAKALGVVGGYIAASASCVDYVRSFGPGFIFSSSMPPATAAAALASIRYLRAHPEIRDRHQERAATAKRLLSARGI
PVLPSVSHIVPVMVGNAALCKEASDLLLNEYGIYVQPINYPTVPVGTERLRITPTPLHDDAMMAHLVDAFSAVWDRLDLH
KVHHPKTIKAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=50.3722084367246, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=50.3722084367246, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=50.3722084367246, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=48.6352357320099, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=48.6352357320099, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI7657118, Length=354, Percent_Identity=37.5706214689266, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=37.6436781609195, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI119220554, Length=437, Percent_Identity=26.7734553775744, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4758668, Length=430, Percent_Identity=25.8139534883721, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI5454084, Length=288, Percent_Identity=29.1666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1790046, Length=355, Percent_Identity=35.7746478873239, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1786993, Length=340, Percent_Identity=36.4705882352941, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=31.75, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=28.1081081081081, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=28.2913165266106, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=28.2913165266106, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=27.7227722772277, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=325, Percent_Identity=27.6923076923077, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=48.1132075471698, Blast_Score=415, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320267, Length=376, Percent_Identity=27.9255319148936, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=25.1937984496124, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=48.1296758104738, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24662918, Length=361, Percent_Identity=36.01108033241, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24653280, Length=300, Percent_Identity=29, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653276, Length=300, Percent_Identity=29, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653278, Length=300, Percent_Identity=29, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136286, Length=431, Percent_Identity=24.5939675174014, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 45068; Mature: 45068

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEHYFTKRISDLKSEGRYRVFADLERQKGRFPIALNYRDGEVREVVVWCSNDYLGMGQ
CCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCEEEECCCCCEEEEEEEECCCCCCCCC
HPEVIAAAHEALERCGAGAGGTRNISGTNHYHVLLEEELASFNAKESSLLFTSGYVANQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCEEEECCCCCCCH
TLSTLGATIPGCVVFSDELNHNSMIEGIRHGRSAKQVFRHNDPEHLEQLLSAYPKETPKL
HHHHHCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCE
VAFESVYSMDGDIAPIAEICDVAEAHNAMTYLDEVHAVGMYGAEGSGVAERDGVRDRITI
EEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHH
IQGTLAKALGVVGGYIAASASCVDYVRSFGPGFIFSSSMPPATAAAALASIRYLRAHPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHH
RDRHQERAATAKRLLSARGIPVLPSVSHIVPVMVGNAALCKEASDLLLNEYGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCC
PTVPVGTERLRITPTPLHDDAMMAHLVDAFSAVWDRLDLHKVHHPKTIKAAE
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDYEHYFTKRISDLKSEGRYRVFADLERQKGRFPIALNYRDGEVREVVVWCSNDYLGMGQ
CCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCEEEECCCCCEEEEEEEECCCCCCCCC
HPEVIAAAHEALERCGAGAGGTRNISGTNHYHVLLEEELASFNAKESSLLFTSGYVANQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCEEEECCCCCCCH
TLSTLGATIPGCVVFSDELNHNSMIEGIRHGRSAKQVFRHNDPEHLEQLLSAYPKETPKL
HHHHHCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCE
VAFESVYSMDGDIAPIAEICDVAEAHNAMTYLDEVHAVGMYGAEGSGVAERDGVRDRITI
EEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHH
IQGTLAKALGVVGGYIAASASCVDYVRSFGPGFIFSSSMPPATAAAALASIRYLRAHPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHH
RDRHQERAATAKRLLSARGIPVLPSVSHIVPVMVGNAALCKEASDLLLNEYGIYVQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCC
PTVPVGTERLRITPTPLHDDAMMAHLVDAFSAVWDRLDLHKVHHPKTIKAAE
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]