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The map label for this gene is thrB

Identifier: 82750925

GI number: 82750925

Start: 1293800

End: 1294714

Strand: Direct

Name: thrB

Synonym: SAB1188

Alternate gene names: 82750925

Gene position: 1293800-1294714 (Clockwise)

Preceding gene: 82750924

Following gene: 82750926

Centisome position: 47.18

GC content: 35.96

Gene sequence:

>915_bases
ATGTCGAATGTTTTGGAGTTAAAAATTCCTGCATCAACAGCCAACCTTGGAGTTGGCTTTGATTCTATAGGTATGGCTTT
AGATAAATTTTTGCATCTGTCTGTAAAGGAAACATCAGGGACAAAATGGGAATATATTTTCCATGATGATGCATCGAAGC
AATTGCCTACTGACGAAACAAACTTTATTTATCATGTGGCACAACAAGTTGCTGCTAAATATAGTGTTGACTTGCCTAAT
TTATGTATCGAAATGAGAAGTGATATTCCATTGGCAAGAGGGTTAGGTTCGTCAGCTTCTGCTTTAGTAGGAGCTATATA
TATCGCAAATTATTTTGGTGATATCCAACTATCTAAACACGAGGTATTACAATTAGCGACTGAAATCGAAGGACATCCTG
ATAATGTTGCGCCGACCATTTATGGTGGTTTAATCTCTGGGTATTATAATGATGTCTCGAAAGAAACGTCAGTTGCACAT
ATCGACATACCAGACGTGGATGTGATTGTAACGATACCAACTTATGAACTAAAAACAGAAGCATCAAGACGTGCTTTACC
ACAAAAATTAACACATAGTGAAGCGGTTAAAAGTAGTGCAATTAGTAATACAATGATTTGTGCATTAGCACAGCACAATT
ATGAATTAGCAGGTAAGCTCATGCAACAAGATGGCTTTCATGAACCGTATCGTCAGCATTTAATTGCTGAATTTGATGAA
GTGAAAACAATTGCTAGTCAACATAATGCCTATGCAACAGTGATTAGTGGTGCTGGACCAACTATTTTAATATTTAGTCG
TAAAGAAAATAGTGGCGAATTGGTTCGCGCTTTAAATAGAAATGTAGTTACATGTCATTCTGAATTAGTAGATATTAATG
TTAGTGGTGTTAAAGAACGAATTGTATACCAATAG

Upstream 100 bases:

>100_bases
AAAGATCCTGATACTGCTATTTCACTACTAGATAATCCGATAAAGCCATTGCCAAATGATAAAGATAGCATTATCGATTA
TATTAAAGGAGCTTTATAAC

Downstream 100 bases:

>100_bases
ACGCTTTATATTGTAAAATAGTATTGAATGTGAAATAGAGAGGAGATTTAATGCGATATGACAAATTATAAAGTTGTCGT
TTTAGATATGGATGACACAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSNVLELKIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPN
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLISGYYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRNVVTCHSELVDINVSGVKERIVYQ

Sequences:

>Translated_304_residues
MSNVLELKIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPN
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLISGYYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRNVVTCHSELVDINVSGVKERIVYQ
>Mature_303_residues
SNVLELKIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPNL
CIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLISGYYNDVSKETSVAHI
DIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEV
KTIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRNVVTCHSELVDINVSGVKERIVYQ

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=284, Percent_Identity=27.4647887323944, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321814, Length=347, Percent_Identity=27.3775216138329, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33333; Mature: 33202

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLELKIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVAAKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLISGYYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRNVVTCHSELVDINVSGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHCCCEEEEEEEEEEEEHHHHHHH
IVYQ
HCCC
>Mature Secondary Structure 
SNVLELKIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVAAKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLISGYYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRNVVTCHSELVDINVSGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHCCCEEEEEEEEEEEEHHHHHHH
IVYQ
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA