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The map label for this gene is lasR [H]

Identifier: 82703532

GI number: 82703532

Start: 2754330

End: 2755064

Strand: Direct

Name: lasR [H]

Synonym: Nmul_A2417

Alternate gene names: 82703532

Gene position: 2754330-2755064 (Clockwise)

Preceding gene: 82703531

Following gene: 82703534

Centisome position: 86.5

GC content: 52.65

Gene sequence:

>735_bases
ATGGATAACTTGACCTTATTCGAATCATTGCTGAATTGCGATTCGGTGGAGGAATTGCACAGCGCTACCACAACCATTGC
CCGCGCAATGGGATTCGAGCATTTTCTGTATGGTGTTCAGGTGAACACTTCTCTCACCCGTCCTTATCGCTTCATCCTCA
GTTGTTATCCGGAGGAATGGCGTAAACATTACGACAAGGAAGGTTATGCCAATTTCGATCCTACGGTTTCGCATTGCGCC
AGAACGTCCATTCCGATCATATGGAAGAAAGAGATTTTCAAGGGACGCAGGGAGACGCGCGTAAGAAACGAGGCCAAGGA
TTGTGGGCTGGTCAGCGGAGCGAGTTTTTCGGTTCATGGCGGACGCGGCGAAGCCGCCATGTTGAGTCTGGCTACTTCAA
GGGAGTCGCGTGAGGCGCAGAATGACATTCTCGCGACAATGGCTAAAGCCCAGTTATTAACCTGCTATCTGCATGAGGCG
GTGCAGCGCATTGTTCTCAGTAAAGGCCCGCTACCTGTGAAGAAGGCCAACCTGACGGAAAGGGAACAAGAATGTCTGCT
ATGGGCCGCCGAGGGCAAGACCGGGTGGGAAATCGCCAACATCGTCAAGATTTCGGAGCGGACAGTAACTTTTCACCTGC
AGAATGCCATCCAGAAACTGGGGGTGGTCAATCGCCAGCAAGCCATATCGCGTGCCCTTTCCATGGGCCTGATCGAGCCC
CGTACGATTCGCTAG

Upstream 100 bases:

>100_bases
GTAGCGGGAATGCCAGGAGCGGGAATCAGCGGGAACGATTGGTAAAGGGTTCACATACAATATCTCGGTCCATAATGCGG
CGTATTATGAGAGGGAAATC

Downstream 100 bases:

>100_bases
CGCGCGTAGCTGCCTGACACTGCCTTACCAGTCAGCCTTCCCCTTCTCATTCGAAGATGAATGATCCGCGGAGAGCTGTA
ATAGGCGCTTCTCATGGCTC

Product: LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MDNLTLFESLLNCDSVEELHSATTTIARAMGFEHFLYGVQVNTSLTRPYRFILSCYPEEWRKHYDKEGYANFDPTVSHCA
RTSIPIIWKKEIFKGRRETRVRNEAKDCGLVSGASFSVHGGRGEAAMLSLATSRESREAQNDILATMAKAQLLTCYLHEA
VQRIVLSKGPLPVKKANLTEREQECLLWAAEGKTGWEIANIVKISERTVTFHLQNAIQKLGVVNRQQAISRALSMGLIEP
RTIR

Sequences:

>Translated_244_residues
MDNLTLFESLLNCDSVEELHSATTTIARAMGFEHFLYGVQVNTSLTRPYRFILSCYPEEWRKHYDKEGYANFDPTVSHCA
RTSIPIIWKKEIFKGRRETRVRNEAKDCGLVSGASFSVHGGRGEAAMLSLATSRESREAQNDILATMAKAQLLTCYLHEA
VQRIVLSKGPLPVKKANLTEREQECLLWAAEGKTGWEIANIVKISERTVTFHLQNAIQKLGVVNRQQAISRALSMGLIEP
RTIR
>Mature_244_residues
MDNLTLFESLLNCDSVEELHSATTTIARAMGFEHFLYGVQVNTSLTRPYRFILSCYPEEWRKHYDKEGYANFDPTVSHCA
RTSIPIIWKKEIFKGRRETRVRNEAKDCGLVSGASFSVHGGRGEAAMLSLATSRESREAQNDILATMAKAQLLTCYLHEA
VQRIVLSKGPLPVKKANLTEREQECLLWAAEGKTGWEIANIVKISERTVTFHLQNAIQKLGVVNRQQAISRALSMGLIEP
RTIR

Specific function: Transcriptional activator of elastase structural gene (lasB). Binds to the PAI autoinducer [H]

COG id: COG2771

COG function: function code K; DNA-binding HTH domain-containing proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH luxR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788224, Length=227, Percent_Identity=26.8722466960352, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016032
- InterPro:   IPR005143
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03472 Autoind_bind; PF00196 GerE [H]

EC number: NA

Molecular weight: Translated: 27527; Mature: 27527

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLTLFESLLNCDSVEELHSATTTIARAMGFEHFLYGVQVNTSLTRPYRFILSCYPEEW
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHH
RKHYDKEGYANFDPTVSHCARTSIPIIWKKEIFKGRRETRVRNEAKDCGLVSGASFSVHG
HHHCCCCCCCCCCHHHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEC
GRGEAAMLSLATSRESREAQNDILATMAKAQLLTCYLHEAVQRIVLSKGPLPVKKANLTE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
REQECLLWAAEGKTGWEIANIVKISERTVTFHLQNAIQKLGVVNRQQAISRALSMGLIEP
HHHHHEEEEECCCCCCHHHHHEEECCHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
RTIR
CCCC
>Mature Secondary Structure
MDNLTLFESLLNCDSVEELHSATTTIARAMGFEHFLYGVQVNTSLTRPYRFILSCYPEEW
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHH
RKHYDKEGYANFDPTVSHCARTSIPIIWKKEIFKGRRETRVRNEAKDCGLVSGASFSVHG
HHHCCCCCCCCCCHHHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEC
GRGEAAMLSLATSRESREAQNDILATMAKAQLLTCYLHEAVQRIVLSKGPLPVKKANLTE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
REQECLLWAAEGKTGWEIANIVKISERTVTFHLQNAIQKLGVVNRQQAISRALSMGLIEP
HHHHHEEEEECCCCCCHHHHHEEECCHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
RTIR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1902216; 7937080; 10984043 [H]