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The map label for this gene is lon [H]

Identifier: 82703455

GI number: 82703455

Start: 2663193

End: 2665604

Strand: Reverse

Name: lon [H]

Synonym: Nmul_A2338

Alternate gene names: 82703455

Gene position: 2665604-2663193 (Counterclockwise)

Preceding gene: 82703456

Following gene: 82703454

Centisome position: 83.71

GC content: 56.01

Gene sequence:

>2412_bases
ATGTCCTCTCCCATGAACGATCAAAATCAGATTTCATTACCTTTGTTGCCATTGCGCGATGTGGTGGTTTTTCCGCACAT
GGTGATTCCCCTGTTTGTCGGCCGGCCCAAGTCCATCAAGGCACTGGAAATAGCGATGGAGTCCGGCAAGAGCATTTTGC
TTGTGGCGCAGAAATTTGCTGCCAAGGACGAGCCGGCTCCCGAAGATTTGTACGGGGTATGCAGCGTTGCAAACCTGCTG
CAAATGCTCAAGCTGCCAGACGGTACCGTGAAAGTATTGGTGGAAGGCGGTCGCCGCGCTCGCATCGTGAAAGTGGTTGA
CGACGGTACGTACTTCGCCGGCGACGCAGCATTGCTGCCGCCCGATGCCGTGGACAACCATGAGGTGGAGGCGATGCGCC
GCGCCATGCTGGCCCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATTCCCCCGGAGATCCTGACTTCGCTCAGCGGC
ATAGACGAAGCAGGTCGTCTGGCTGATACCATCGCCGCACACCTGCCCTTGAAGCTTGAGCAGAAGCAGGAAGTGCTGGA
AATTTTCGACGTGCCGAAGCGCCTGGAACACCTGCTTGGTCTGCTGGAAACCGAGCTTGACATACTTCAGGTGGAAAAGC
GTATTCGTGGTCGTGTAAAGCGGCAGATGGAAAAAAGCCAGCGGGATTACTATCTCAATGAGCAGGTGAAGGCCATCCAG
AAGGAATTGGGTGAAGGCGAGGAAGGCGCTGATCTGGAAGAGATGGACAAGAAGATCAAAAACGCCCAGATGTCCAAGGA
GGCGCGTGCCAAGGCGGAATCGGAGTTGAAAAAACTGCGGTTGATGTCGCCCATGTCGGCAGAAGCCACTGTCGTGCGTA
ATTATATTGATGCGCTGGTGGCCCTGCCATGGAAGAAGAAAAGCAAGATAAGCAAAGACCTCAGCGTTGCGGAAGCCGTG
CTCGAGCAGGATCACTACGGCCTGGAAAAAGTCAAGGAACGGATTGTCGAGTATCTGGCGGTACAGCAGCGCGTGGATAA
GTTGAAAGCGCCCATCCTCTGCCTGGTGGGGCCGCCCGGGGTAGGGAAGACTTCATTGGGGCAATCGATCGCCCGGGCTA
CCAACCGGAAGTTCGTCCGCATGTCGCTCGGCGGCGTCAGGGATGAAGCAGAGGTACGTGGTCATCGCCGCACCTATATC
GGTTCCATGCCTGGCAAGATTCTGCAGAACATGGCGAAAGTGGGTGTGAAGAACCCCTTGTTCCTGCTGGACGAGGTGGA
CAAGATGGGCATGGATTTTCGGGGTGATCCGTCCTCTGCGCTCCTGGAAGTGCTGGATCCCGAGCAGAATAATTCGTTCG
TCGATCACTATGTCGAGGTTGAGTACGATCTGTCGGACGTCATGTTCGTCGCGACTGCGAATACGTTGAACATCCCTGCG
CCGCTGCTGGATCGCATGGAAGTGATCCGGCTGTCCGGCTATACCGAGGATGAAAAACTCAACATCGCGACACGCTATCT
GTTGCCGAAACAGATGAAAAATCACGGTTTGAAGGAAAATGAACTGACCGTCTCGGAGTCAGCCCTGCGGGATATCACGC
GCTATTACACCCGTGAAGCGGGCGTGCGGGCGATGGAGCGGGAAATTTCCAAAATATGCCGTAAAGTGGTCAAGGCGTTG
CTGCTGAAAGGCGGGCAGAAACGGATTACCGTCACCGGGAGGAACCTGGACAAATATCTCGGTGTAAGGCGCTATACCTA
CGGTGTCGCGGAGGAAAAGAACCAGATCGGCCAAGTGACGGGCCTCGCCTGGACCGAGGTCGGGGGGGAATTGCTGACGA
TCGAGGCCGTCGTATTGCCGGGTAAGGGTAAATCCATCACGACCGGCAAACTGGGCGAGGTCATGCAGGAATCTGTCCAG
GCTGCCCTGTCGGTGGTTCGCAGCCGCTCAAGGGCTCTGGGTATCGCGGATGATTTTTACCAGAAGAACGACATCCATAT
CCATCTGCCGGAGGGTGCGACCCCGAAAGACGGTCCCAGTGCCGGTATAGGTATCTGCGTGGCGATGGTGTCGGCGTTGA
CCAACATTCCGGCCCGCGCAACTGTCGCGATGACCGGTGAGATCACACTTCGCGGTGAGGTGCTGGCGATTGGCGGACTC
AAGGAAAAACTGCTCGCCGCGCATCGCGGCGGCATAAAGACTGTGCTGATTCCCGAGGATAACGTTAAGGATCTGAACGA
AATCCCGGAGAATATCAAAAACAAGCTGGATATTCATCCGGTCAAATGGATAGATCAGGTGCTGGATCTGGCCCTGGAAT
CCAAACCGGAACCGCTTCCGGCCGCTCCTTCATCCGTTCCCTCTCCTGTTGCGGTGGAAGGCGATGTGACGCCGGCGGTC
ATCAAGCACTAG

Upstream 100 bases:

>100_bases
CTGCTAGTCCGGGTTTCATGTTTCGACATTGCCGTCGTTGCCTTGAATTTCTTTACGGCGCCCCCATAACTATTGTTTGT
TTCTTTATAGGTGAGCCGAT

Downstream 100 bases:

>100_bases
GTTCGTCAAAGACTCCGTACAGAGTGATGGGGAGTAATGGCTTGCAAGGGTCTTATAAAGCGAAGTGGAAATATTTTGAC
AATGGCTTGACCAGGCACAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MSSPMNDQNQISLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEIAMESGKSILLVAQKFAAKDEPAPEDLYGVCSVANLL
QMLKLPDGTVKVLVEGGRRARIVKVVDDGTYFAGDAALLPPDAVDNHEVEAMRRAMLAQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLEQKQEVLEIFDVPKRLEHLLGLLETELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKAIQ
KELGEGEEGADLEEMDKKIKNAQMSKEARAKAESELKKLRLMSPMSAEATVVRNYIDALVALPWKKKSKISKDLSVAEAV
LEQDHYGLEKVKERIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMSLGGVRDEAEVRGHRRTYI
GSMPGKILQNMAKVGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNSFVDHYVEVEYDLSDVMFVATANTLNIPA
PLLDRMEVIRLSGYTEDEKLNIATRYLLPKQMKNHGLKENELTVSESALRDITRYYTREAGVRAMEREISKICRKVVKAL
LLKGGQKRITVTGRNLDKYLGVRRYTYGVAEEKNQIGQVTGLAWTEVGGELLTIEAVVLPGKGKSITTGKLGEVMQESVQ
AALSVVRSRSRALGIADDFYQKNDIHIHLPEGATPKDGPSAGIGICVAMVSALTNIPARATVAMTGEITLRGEVLAIGGL
KEKLLAAHRGGIKTVLIPEDNVKDLNEIPENIKNKLDIHPVKWIDQVLDLALESKPEPLPAAPSSVPSPVAVEGDVTPAV
IKH

Sequences:

>Translated_803_residues
MSSPMNDQNQISLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEIAMESGKSILLVAQKFAAKDEPAPEDLYGVCSVANLL
QMLKLPDGTVKVLVEGGRRARIVKVVDDGTYFAGDAALLPPDAVDNHEVEAMRRAMLAQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLEQKQEVLEIFDVPKRLEHLLGLLETELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKAIQ
KELGEGEEGADLEEMDKKIKNAQMSKEARAKAESELKKLRLMSPMSAEATVVRNYIDALVALPWKKKSKISKDLSVAEAV
LEQDHYGLEKVKERIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMSLGGVRDEAEVRGHRRTYI
GSMPGKILQNMAKVGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNSFVDHYVEVEYDLSDVMFVATANTLNIPA
PLLDRMEVIRLSGYTEDEKLNIATRYLLPKQMKNHGLKENELTVSESALRDITRYYTREAGVRAMEREISKICRKVVKAL
LLKGGQKRITVTGRNLDKYLGVRRYTYGVAEEKNQIGQVTGLAWTEVGGELLTIEAVVLPGKGKSITTGKLGEVMQESVQ
AALSVVRSRSRALGIADDFYQKNDIHIHLPEGATPKDGPSAGIGICVAMVSALTNIPARATVAMTGEITLRGEVLAIGGL
KEKLLAAHRGGIKTVLIPEDNVKDLNEIPENIKNKLDIHPVKWIDQVLDLALESKPEPLPAAPSSVPSPVAVEGDVTPAV
IKH
>Mature_802_residues
SSPMNDQNQISLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEIAMESGKSILLVAQKFAAKDEPAPEDLYGVCSVANLLQ
MLKLPDGTVKVLVEGGRRARIVKVVDDGTYFAGDAALLPPDAVDNHEVEAMRRAMLAQFDQYVKLNKKIPPEILTSLSGI
DEAGRLADTIAAHLPLKLEQKQEVLEIFDVPKRLEHLLGLLETELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKAIQK
ELGEGEEGADLEEMDKKIKNAQMSKEARAKAESELKKLRLMSPMSAEATVVRNYIDALVALPWKKKSKISKDLSVAEAVL
EQDHYGLEKVKERIVEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMSLGGVRDEAEVRGHRRTYIG
SMPGKILQNMAKVGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNSFVDHYVEVEYDLSDVMFVATANTLNIPAP
LLDRMEVIRLSGYTEDEKLNIATRYLLPKQMKNHGLKENELTVSESALRDITRYYTREAGVRAMEREISKICRKVVKALL
LKGGQKRITVTGRNLDKYLGVRRYTYGVAEEKNQIGQVTGLAWTEVGGELLTIEAVVLPGKGKSITTGKLGEVMQESVQA
ALSVVRSRSRALGIADDFYQKNDIHIHLPEGATPKDGPSAGIGICVAMVSALTNIPARATVAMTGEITLRGEVLAIGGLK
EKLLAAHRGGIKTVLIPEDNVKDLNEIPENIKNKLDIHPVKWIDQVLDLALESKPEPLPAAPSSVPSPVAVEGDVTPAVI
KH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=661, Percent_Identity=40.9984871406959, Blast_Score=501, Evalue=1e-141,
Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=43.9929328621908, Blast_Score=496, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=768, Percent_Identity=68.8802083333333, Blast_Score=1074, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=40, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=39.2592592592593, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=710, Percent_Identity=39.5774647887324, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=43.5483870967742, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=43.5483870967742, Blast_Score=497, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88590; Mature: 88459

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPMNDQNQISLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEIAMESGKSILLVAQKFA
CCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEHHHH
AKDEPAPEDLYGVCSVANLLQMLKLPDGTVKVLVEGGRRARIVKVVDDGTYFAGDAALLP
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCEEECCCCCCC
PDAVDNHEVEAMRRAMLAQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKLE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEIFDVPKRLEHLLGLLETELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKAIQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KELGEGEEGADLEEMDKKIKNAQMSKEARAKAESELKKLRLMSPMSAEATVVRNYIDALV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ALPWKKKSKISKDLSVAEAVLEQDHYGLEKVKERIVEYLAVQQRVDKLKAPILCLVGPPG
HCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMSLGGVRDEAEVRGHRRTYIGSMPGKILQNMAKVGVKNPL
CCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCC
FLLDEVDKMGMDFRGDPSSALLEVLDPEQNNSFVDHYVEVEYDLSDVMFVATANTLNIPA
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKLNIATRYLLPKQMKNHGLKENELTVSESALRDITRYYTREA
HHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRAMEREISKICRKVVKALLLKGGQKRITVTGRNLDKYLGVRRYTYGVAEEKNQIGQVT
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
GLAWTEVGGELLTIEAVVLPGKGKSITTGKLGEVMQESVQAALSVVRSRSRALGIADDFY
CCCHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKNDIHIHLPEGATPKDGPSAGIGICVAMVSALTNIPARATVAMTGEITLRGEVLAIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCEEEECCH
KEKLLAAHRGGIKTVLIPEDNVKDLNEIPENIKNKLDIHPVKWIDQVLDLALESKPEPLP
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
AAPSSVPSPVAVEGDVTPAVIKH
CCCCCCCCCEEECCCCCHHHHCC
>Mature Secondary Structure 
SSPMNDQNQISLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEIAMESGKSILLVAQKFA
CCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEHHHH
AKDEPAPEDLYGVCSVANLLQMLKLPDGTVKVLVEGGRRARIVKVVDDGTYFAGDAALLP
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCEEECCCCCCC
PDAVDNHEVEAMRRAMLAQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKLE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEIFDVPKRLEHLLGLLETELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKAIQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KELGEGEEGADLEEMDKKIKNAQMSKEARAKAESELKKLRLMSPMSAEATVVRNYIDALV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ALPWKKKSKISKDLSVAEAVLEQDHYGLEKVKERIVEYLAVQQRVDKLKAPILCLVGPPG
HCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMSLGGVRDEAEVRGHRRTYIGSMPGKILQNMAKVGVKNPL
CCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCC
FLLDEVDKMGMDFRGDPSSALLEVLDPEQNNSFVDHYVEVEYDLSDVMFVATANTLNIPA
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKLNIATRYLLPKQMKNHGLKENELTVSESALRDITRYYTREA
HHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRAMEREISKICRKVVKALLLKGGQKRITVTGRNLDKYLGVRRYTYGVAEEKNQIGQVT
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
GLAWTEVGGELLTIEAVVLPGKGKSITTGKLGEVMQESVQAALSVVRSRSRALGIADDFY
CCCHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKNDIHIHLPEGATPKDGPSAGIGICVAMVSALTNIPARATVAMTGEITLRGEVLAIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCEEEECCH
KEKLLAAHRGGIKTVLIPEDNVKDLNEIPENIKNKLDIHPVKWIDQVLDLALESKPEPLP
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
AAPSSVPSPVAVEGDVTPAVIKH
CCCCCCCCCEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]