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The map label for this gene is gpmA

Identifier: 82702250

GI number: 82702250

Start: 1293048

End: 1293803

Strand: Reverse

Name: gpmA

Synonym: Nmul_A1121

Alternate gene names: 82702250

Gene position: 1293803-1293048 (Counterclockwise)

Preceding gene: 82702256

Following gene: 82702249

Centisome position: 40.63

GC content: 53.44

Gene sequence:

>756_bases
ATGAAAAAACTCGTTCTCCTGCGACATGGAGAAAGTACCTGGAACAAGGAGAATCGCTTTACGGGCTGGACAGACGTGGA
CTTAACTCCAAAAGGAGCGGAGGAGGCCCACAATTCCGGACGCCTGCTGCGGGAAGCCGGATTCACCTTCGATATCGCCT
ATACTTCGGTACTGAAGCGCGCCATTCGCACATTATGGATCGTGCTGGATGAAATGGATCAGATGTGGATTCCCGTCGAA
TCATCGTGGCGGCTGAATGAGCGTCATTATGGGGCGCTGCAAGGCCTGAACAAACTTGAAACTGCAGTTGCATATGGTGA
AGAGCAGGTATTGATCTGGCGGCGAAGTTACGATATTCGCCCCCCCGCCCTCACTCCCGATGATCCCCGGTACCCGGGAT
GCGACCCTCGCTACCGGAACTTGCCAAAGCAGGATATTCCCCTTACCGAGTGCCTGCAGGATACCGTGTCACGGTTTCTG
CCCTATTGGCGTGAAAGCATTGCTCCCCAGGTCAAAAGTGACAAAAGCGTGCTCATCACCGCGCATGGAAATTCGCTCCG
GGCCCTCGTCATGTATCTTGACAACCTTTCCGAAGGGGAAATCATGGAGCTCAATATTCCGACCGGCATTCCGCTCGTAT
ATGAGCTTGACGACGGCCTGAAACCAATCCGCAGCTATTATCTCGGAGACCAGGCAAAAATCGAGCAGGCCATGCAGGTC
GTCGCGAATCAGGGAAAAATTCTGCCCAACCTTTAA

Upstream 100 bases:

>100_bases
TCCTGTAGAGGTGACAGTTGGCCAGGCTGCTGCGGTAGTATCGAAAATACGGTAAAATTTAAAGTTTTCCCGTCGCGGAA
AATCTTATCTACCCAAGAAC

Downstream 100 bases:

>100_bases
CTTTTGGTTTAATCTCTGTTTTTCCTATTGCCGTACTTGCCGTGCCTGTTCTTTATACGCATACTCTCTGACTTCTGGTC
CGGCTGCCTTTTCCTTCTCA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM 2; PGAM 2; Phosphoglyceromutase 2; dPGM 2

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKKLVLLRHGESTWNKENRFTGWTDVDLTPKGAEEAHNSGRLLREAGFTFDIAYTSVLKRAIRTLWIVLDEMDQMWIPVE
SSWRLNERHYGALQGLNKLETAVAYGEEQVLIWRRSYDIRPPALTPDDPRYPGCDPRYRNLPKQDIPLTECLQDTVSRFL
PYWRESIAPQVKSDKSVLITAHGNSLRALVMYLDNLSEGEIMELNIPTGIPLVYELDDGLKPIRSYYLGDQAKIEQAMQV
VANQGKILPNL

Sequences:

>Translated_251_residues
MKKLVLLRHGESTWNKENRFTGWTDVDLTPKGAEEAHNSGRLLREAGFTFDIAYTSVLKRAIRTLWIVLDEMDQMWIPVE
SSWRLNERHYGALQGLNKLETAVAYGEEQVLIWRRSYDIRPPALTPDDPRYPGCDPRYRNLPKQDIPLTECLQDTVSRFL
PYWRESIAPQVKSDKSVLITAHGNSLRALVMYLDNLSEGEIMELNIPTGIPLVYELDDGLKPIRSYYLGDQAKIEQAMQV
VANQGKILPNL
>Mature_251_residues
MKKLVLLRHGESTWNKENRFTGWTDVDLTPKGAEEAHNSGRLLREAGFTFDIAYTSVLKRAIRTLWIVLDEMDQMWIPVE
SSWRLNERHYGALQGLNKLETAVAYGEEQVLIWRRSYDIRPPALTPDDPRYPGCDPRYRNLPKQDIPLTECLQDTVSRFL
PYWRESIAPQVKSDKSVLITAHGNSLRALVMYLDNLSEGEIMELNIPTGIPLVYELDDGLKPIRSYYLGDQAKIEQAMQV
VANQGKILPNL

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=247, Percent_Identity=60.7287449392713, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI50593010, Length=247, Percent_Identity=56.2753036437247, Blast_Score=295, Evalue=2e-80,
Organism=Homo sapiens, GI71274132, Length=247, Percent_Identity=58.2995951417004, Blast_Score=283, Evalue=7e-77,
Organism=Homo sapiens, GI4502445, Length=250, Percent_Identity=49.2, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI40353764, Length=250, Percent_Identity=49.2, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=61.4906832298137, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786970, Length=246, Percent_Identity=65.0406504065041, Blast_Score=341, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=50, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320183, Length=299, Percent_Identity=33.4448160535117, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324516, Length=286, Percent_Identity=31.8181818181818, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646216, Length=249, Percent_Identity=51.4056224899598, Blast_Score=260, Evalue=5e-70,
Organism=Drosophila melanogaster, GI85725270, Length=248, Percent_Identity=53.2258064516129, Blast_Score=260, Evalue=7e-70,
Organism=Drosophila melanogaster, GI85725272, Length=248, Percent_Identity=53.2258064516129, Blast_Score=260, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24650981, Length=248, Percent_Identity=53.2258064516129, Blast_Score=260, Evalue=7e-70,
Organism=Drosophila melanogaster, GI28571815, Length=248, Percent_Identity=38.7096774193548, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28571817, Length=248, Percent_Identity=38.7096774193548, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24648979, Length=248, Percent_Identity=38.7096774193548, Blast_Score=167, Evalue=4e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA2_NITMU (Q2Y9Z7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411816.1
- ProteinModelPortal:   Q2Y9Z7
- SMR:   Q2Y9Z7
- STRING:   Q2Y9Z7
- GeneID:   3785701
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1121
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q2Y9Z7
- ProtClustDB:   PRK14115
- BioCyc:   NMUL323848:NMUL_A1121-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28814; Mature: 28814

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLLRHGESTWNKENRFTGWTDVDLTPKGAEEAHNSGRLLREAGFTFDIAYTSVLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCEEEHHHHHHHHH
AIRTLWIVLDEMDQMWIPVESSWRLNERHYGALQGLNKLETAVAYGEEQVLIWRRSYDIR
HHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
PPALTPDDPRYPGCDPRYRNLPKQDIPLTECLQDTVSRFLPYWRESIAPQVKSDKSVLIT
CCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVMYLDNLSEGEIMELNIPTGIPLVYELDDGLKPIRSYYLGDQAKIEQAMQV
ECCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VANQGKILPNL
HHHCCCCCCCC
>Mature Secondary Structure
MKKLVLLRHGESTWNKENRFTGWTDVDLTPKGAEEAHNSGRLLREAGFTFDIAYTSVLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCEEEHHHHHHHHH
AIRTLWIVLDEMDQMWIPVESSWRLNERHYGALQGLNKLETAVAYGEEQVLIWRRSYDIR
HHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
PPALTPDDPRYPGCDPRYRNLPKQDIPLTECLQDTVSRFLPYWRESIAPQVKSDKSVLIT
CCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVMYLDNLSEGEIMELNIPTGIPLVYELDDGLKPIRSYYLGDQAKIEQAMQV
ECCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VANQGKILPNL
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA