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The map label for this gene is mtnP [H]

Identifier: 82701783

GI number: 82701783

Start: 748672

End: 749418

Strand: Direct

Name: mtnP [H]

Synonym: Nmul_A0650

Alternate gene names: 82701783

Gene position: 748672-749418 (Clockwise)

Preceding gene: 82701782

Following gene: 82701784

Centisome position: 23.51

GC content: 55.29

Gene sequence:

>747_bases
ATGCTTGCAATTATTGGCGGGACCGGAATGGCCCAGCTCGAGTGCCTTGAAATTTCCCATCAGAAAGTTGTAACGACTCC
TTATGGGGAACCATCAGGCCCTCTGACTTTTGGCAAGATACGTAACAATACCGTCGTTTTTCTGGCGCGTCATGGATACG
GCCATACGATTCCTCCCCACGAGGTGAATTACCGCGCCAACTTGTGGGCATTGCAGTCGGTTAATCTGACGAGGGTGATA
GCGGTTGCTTCGGTAGGTGGAATCCGTGCTGATCTCGCACCGGGCACGGTAGTGATTCCCGACCAGATCATCGACTATAC
CTACGGTCGCAAGTATACCTATTACGATGGCAAGGACCGGTCAGTGACCTACATCGATTTCACCGAGCCATACTGTCCTT
TGACTCGCAAGCGTCTCCTGGAAGCAGCGGGACGTGCCGGCGAAAAGGTGCTTGACGGAGGGGTGTATGGCGCGACCCAG
GGGCCACGGCTTGAAACTGCGGCGGAAGTCAACCGGCTGGAGCGGGATGGGGTTGACATGGTTGGAATGACTGGTATGCC
TGAGGCCGCCCTCGCCAAGGAGCTGGGGCTATGCTACGCAACCCTGGCAGTAGTCGCAAATTATGCGGCCGGCCGTAAAA
GCAGTGCCCATCTCATCCGTCTGGATGAGGCGCATGGCGTTCTGGAAAAAACGATGGTCAGGGTCAGAAATATTCTCGAA
TGGGTGGTAACGCTCGATGCCGATTAA

Upstream 100 bases:

>100_bases
CCCAACCGCTACGTCTTTGGCTTCGGCATGGATATCTATGGGGCATGGCGAAATTTGCCCGCCATCTATGCCTTGAAAGA
GTGAGGTAAAATCCAGAAAT

Downstream 100 bases:

>100_bases
ACCTGTCCTCAAAATGGGAGATCCCCGCCTACTGGAAGTGGCTCGGAAGGTGGAGAATTTCAGCACGCCCGAATTCGGAG
CATTGCTTCGAGACATGCAT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLAIIGGTGMAQLECLEISHQKVVTTPYGEPSGPLTFGKIRNNTVVFLARHGYGHTIPPHEVNYRANLWALQSVNLTRVI
AVASVGGIRADLAPGTVVIPDQIIDYTYGRKYTYYDGKDRSVTYIDFTEPYCPLTRKRLLEAAGRAGEKVLDGGVYGATQ
GPRLETAAEVNRLERDGVDMVGMTGMPEAALAKELGLCYATLAVVANYAAGRKSSAHLIRLDEAHGVLEKTMVRVRNILE
WVVTLDAD

Sequences:

>Translated_248_residues
MLAIIGGTGMAQLECLEISHQKVVTTPYGEPSGPLTFGKIRNNTVVFLARHGYGHTIPPHEVNYRANLWALQSVNLTRVI
AVASVGGIRADLAPGTVVIPDQIIDYTYGRKYTYYDGKDRSVTYIDFTEPYCPLTRKRLLEAAGRAGEKVLDGGVYGATQ
GPRLETAAEVNRLERDGVDMVGMTGMPEAALAKELGLCYATLAVVANYAAGRKSSAHLIRLDEAHGVLEKTMVRVRNILE
WVVTLDAD
>Mature_248_residues
MLAIIGGTGMAQLECLEISHQKVVTTPYGEPSGPLTFGKIRNNTVVFLARHGYGHTIPPHEVNYRANLWALQSVNLTRVI
AVASVGGIRADLAPGTVVIPDQIIDYTYGRKYTYYDGKDRSVTYIDFTEPYCPLTRKRLLEAAGRAGEKVLDGGVYGATQ
GPRLETAAEVNRLERDGVDMVGMTGMPEAALAKELGLCYATLAVVANYAAGRKSSAHLIRLDEAHGVLEKTMVRVRNILE
WVVTLDAD

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=257, Percent_Identity=38.9105058365759, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71980569, Length=215, Percent_Identity=38.1395348837209, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323045, Length=246, Percent_Identity=29.6747967479675, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20130079, Length=241, Percent_Identity=36.0995850622407, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221459247, Length=209, Percent_Identity=36.3636363636364, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26992; Mature: 26992

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIIGGTGMAQLECLEISHQKVVTTPYGEPSGPLTFGKIRNNTVVFLARHGYGHTIPPH
CEEEEECCCCEEEEEEEECCCEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCC
EVNYRANLWALQSVNLTRVIAVASVGGIRADLAPGTVVIPDQIIDYTYGRKYTYYDGKDR
CCCCEEEEEEEECCCCEEEEEEHHCCCEEECCCCCEEEECHHHHHHCCCCEEEEECCCCC
SVTYIDFTEPYCPLTRKRLLEAAGRAGEKVLDGGVYGATQGPRLETAAEVNRLERDGVDM
EEEEEECCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAALAKELGLCYATLAVVANYAAGRKSSAHLIRLDEAHGVLEKTMVRVRNILE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHH
WVVTLDAD
HHEEECCC
>Mature Secondary Structure
MLAIIGGTGMAQLECLEISHQKVVTTPYGEPSGPLTFGKIRNNTVVFLARHGYGHTIPPH
CEEEEECCCCEEEEEEEECCCEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCC
EVNYRANLWALQSVNLTRVIAVASVGGIRADLAPGTVVIPDQIIDYTYGRKYTYYDGKDR
CCCCEEEEEEEECCCCEEEEEEHHCCCEEECCCCCEEEECHHHHHHCCCCEEEEECCCCC
SVTYIDFTEPYCPLTRKRLLEAAGRAGEKVLDGGVYGATQGPRLETAAEVNRLERDGVDM
EEEEEECCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAALAKELGLCYATLAVVANYAAGRKSSAHLIRLDEAHGVLEKTMVRVRNILE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHH
WVVTLDAD
HHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]