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The map label for this gene is hpt [H]

Identifier: 82701782

GI number: 82701782

Start: 748110

End: 748655

Strand: Direct

Name: hpt [H]

Synonym: Nmul_A0649

Alternate gene names: 82701782

Gene position: 748110-748655 (Clockwise)

Preceding gene: 82701781

Following gene: 82701783

Centisome position: 23.49

GC content: 54.4

Gene sequence:

>546_bases
ATGCTCCCATACCAGGATGCGCAGAAAATTCTGAGAGAAGCAGAGCAGATATTTCCGGCCGAGGTCGTAGTGGAAACCGT
CAGGCGTATGGCAGCCGATATTACGGCTACCCTGGCACATCGTTATCCCCTGGTGCTCAGCATCATGGGGGGTGCCGTCG
TGTTTACCGGGCAACTGCTTCCCCTGCTGCAATTCCCGCTCAATTTCGACTATCTTCATGTCAGCCGTTACGCTGAGAAG
ATGCACGGGGGCAGGATCGACTGGAAAGCTTCACCGGGCGAGAATGTGCAAGACCGGGTCGTACTGGTGGTGGATGATAT
CCTTGACCAGGGGATCACGCTTGCTGCCATCCGTGAGTGGGTGATGAGCCAAGGCGCAGCAGCATTTTATAGCGCCGTTT
TTGCCGAAAAGGATATTCCTGGTCCCAAGCCGATCAGTGCGGATTTTGTGGGTCTTGTTGTTCCCAACCGCTACGTCTTT
GGCTTCGGCATGGATATCTATGGGGCATGGCGAAATTTGCCCGCCATCTATGCCTTGAAAGAGTGA

Upstream 100 bases:

>100_bases
ATCTCGACGCCAGATGCAGTGGGCATACCAGCGTCTAGCCATCTATCCGCTGCCGATCGATTTTTCCTGCTCCTTATTCT
TCATCAGGTTACCCGTGCCG

Downstream 100 bases:

>100_bases
GGTAAAATCCAGAAATATGCTTGCAATTATTGGCGGGACCGGAATGGCCCAGCTCGAGTGCCTTGAAATTTCCCATCAGA
AAGTTGTAACGACTCCTTAT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MLPYQDAQKILREAEQIFPAEVVVETVRRMAADITATLAHRYPLVLSIMGGAVVFTGQLLPLLQFPLNFDYLHVSRYAEK
MHGGRIDWKASPGENVQDRVVLVVDDILDQGITLAAIREWVMSQGAAAFYSAVFAEKDIPGPKPISADFVGLVVPNRYVF
GFGMDIYGAWRNLPAIYALKE

Sequences:

>Translated_181_residues
MLPYQDAQKILREAEQIFPAEVVVETVRRMAADITATLAHRYPLVLSIMGGAVVFTGQLLPLLQFPLNFDYLHVSRYAEK
MHGGRIDWKASPGENVQDRVVLVVDDILDQGITLAAIREWVMSQGAAAFYSAVFAEKDIPGPKPISADFVGLVVPNRYVF
GFGMDIYGAWRNLPAIYALKE
>Mature_181_residues
MLPYQDAQKILREAEQIFPAEVVVETVRRMAADITATLAHRYPLVLSIMGGAVVFTGQLLPLLQFPLNFDYLHVSRYAEK
MHGGRIDWKASPGENVQDRVVLVVDDILDQGITLAAIREWVMSQGAAAFYSAVFAEKDIPGPKPISADFVGLVVPNRYVF
GFGMDIYGAWRNLPAIYALKE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=27.4853801169591, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20142; Mature: 20142

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPYQDAQKILREAEQIFPAEVVVETVRRMAADITATLAHRYPLVLSIMGGAVVFTGQLL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
PLLQFPLNFDYLHVSRYAEKMHGGRIDWKASPGENVQDRVVLVVDDILDQGITLAAIREW
HHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHEEEEEHHHHHCCCHHHHHHHH
VMSQGAAAFYSAVFAEKDIPGPKPISADFVGLVVPNRYVFGFGMDIYGAWRNLPAIYALK
HHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEECHHHHHHHHCCCEEEEEC
E
C
>Mature Secondary Structure
MLPYQDAQKILREAEQIFPAEVVVETVRRMAADITATLAHRYPLVLSIMGGAVVFTGQLL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
PLLQFPLNFDYLHVSRYAEKMHGGRIDWKASPGENVQDRVVLVVDDILDQGITLAAIREW
HHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHEEEEEHHHHHCCCHHHHHHHH
VMSQGAAAFYSAVFAEKDIPGPKPISADFVGLVVPNRYVFGFGMDIYGAWRNLPAIYALK
HHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEECHHHHHHHHCCCEEEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]