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The map label for this gene is pyrG

Identifier: 78780167

GI number: 78780167

Start: 1674458

End: 1676068

Strand: Direct

Name: pyrG

Synonym: PMT9312_1782

Alternate gene names: 78780167

Gene position: 1674458-1676068 (Clockwise)

Preceding gene: 78780166

Following gene: 78780168

Centisome position: 97.97

GC content: 34.2

Gene sequence:

>1611_bases
ATGTCAAAATTTGTTTTTGTCACCGGAGGAGTAGTTTCTAGCATTGGTAAAGGAATTGTAGCTGCAAGCTTAGGGAGATT
ATTAAAGTCTAGAGGATATAGTGTTTCAATATTAAAACTAGATCCATACCTAAATGTTGATCCAGGCACAATGAGCCCTT
TCCAACATGGAGAAGTATTTGTAACCGAAGATGGGGCTGAAACAGATTTAGATTTAGGTCACTATGAAAGATTTACTGAT
ACTGCAATGACTAGGTTAAATAGTGTGACTACGGGATCTATCTATCAAGCAGTTATTAATAAAGAAAGAAGAGGTAGTTA
TAACGGTGGAACTGTGCAAGTAATTCCTCACATAACGAGAGAAATAAGAGAAAGAATTCATAGAGTAGCCTCCAACAGCA
ATGCGGATATTATTATTACTGAAATTGGTGGAACAGTTGGTGATATTGAATCTTTACCTTTTTTAGAGGCAATAAGAGAA
TTTAAAAATGATGTCAATAGGAATGATGTTGCATACATCCACGTAACATTACTTCCTTACATCAAAACCTCTGGCGAAAT
AAAAACTAAACCAACACAACATTCAGTGAAAGAATTAAGATCAATTGGAATTCAGCCAGATTTACTTGTATGTCGCAGTG
ACAAATCAATCAATGAAGGTCTTAAAAAGAAGCTTAGTGGATTTTGTGGAGTTAATATAAACTCTGTAATTGAAGCATTA
GACGCAGATAGTATTTATTCTGTTCCTCTTTCTTTAAAAAAAGAAGGTTTGTGCAAAGAAACTCTGAAGTATCTAGAACT
TGAAGATAAAGAATGTGATTTGAAAAATTGGGAAAAACTAGTTCACAATCTAAGAAATCCTGGAACTCCTATAAAAGTTG
CTCTAGTAGGTAAATATATTGAACTTGGAGATGCATATTTATCTGTTGTTGAAGCTTTAAGACATGCATGCATTGAACAA
AAGGCTTTATTAGATTTACATTGGGTAAGCGCTGAAATGATAGAAAAAGATTCAGCAGAAACTTACTTGAATGAAGTGGA
TGCGATTGTCGTACCTGGGGGCTTTGGAAATAGGGGAGTTAATGGCAAAATTTCGGCTATAAAATTCGCAAGAGAGAATA
AAATTCCATTTTTAGGCCTGTGCCTTGGTATGCAATGTGCAGTTATAGAATGGGCTAGAAATGTAGCGAATCTTCCAGAT
GCATCTAGTTCGGAACTAGACCCAAAAACTCCCAATCCAGTTATACATTTATTACCAGAACAGGAAGATGTAGTTGATTT
AGGCGGGACAATGAGACTTGGAGTTTATCCATGTAGATTGACAAATAATACAATTGGGAAAAAATTGTATGATGAAGATG
TTATTTATGAGAGACATCGACATAGATACGAATTTAATAATTACTACAAGCAAAGTTTTTTAAATTCTGGATACAAAATT
AGTGGTACATCTCCAGATGGCAGACTAGTAGAGTTAATTGAGTTAGACAATCATCCTTATTTTTTGGCATGTCAATATCA
TCCTGAGTTTTTATCAAGACCTGGCAAACCTCATCCTTTATTTAAAGGCTTAATAAAATCCTCTCAAGAAAACTTAACTC
AATCAAATTAA

Upstream 100 bases:

>100_bases
TATTGAAATAACAATTGATGAATAAGAATATATATGGATGTTCTAAAAGTTTTTTGTTTAAATAAAATATAAGGAGGCTG
TGCTTAATTAAAAATATTTA

Downstream 100 bases:

>100_bases
TATTCCTTATTTGTTTGAATGAAAATGACAAATTTTTTACCCTTAGTCGAACAATTTCATTCATTACAAGGTGAAGGCTA
TCATGCTGGGAAAAGTGCTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITREIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIRE
FKNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEAL
DADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYIELGDAYLSVVEALRHACIEQ
KALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPD
ASSSELDPKTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKI
SGTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN

Sequences:

>Translated_536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITREIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIRE
FKNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEAL
DADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYIELGDAYLSVVEALRHACIEQ
KALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPD
ASSSELDPKTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKI
SGTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN
>Mature_535_residues
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDT
AMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITREIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIREF
KNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEALD
ADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYIELGDAYLSVVEALRHACIEQK
ALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDA
SSSELDPKTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKIS
GTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=553, Percent_Identity=45.5696202531646, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=46.4609800362976, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=46.4609800362976, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=46.4609800362976, Blast_Score=476, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=52.3191094619666, Blast_Score=571, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=38.6776859504132, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=43.9929328621908, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=42.831541218638, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24664469, Length=554, Percent_Identity=46.028880866426, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=499, Percent_Identity=44.8897795591182, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59666; Mature: 59535

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITR
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHH
EIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIREFKNDVNRNDVAYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHH
DADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYI
CCCCEEECCCHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHH
ELGDAYLSVVEALRHACIEQKALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCCCCCCC
NGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDASSSELDPKTPNPVIHLLPE
CCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKI
CCCHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEE
SGTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN
ECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITR
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHH
EIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIREFKNDVNRNDVAYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHH
DADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYI
CCCCEEECCCHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHH
ELGDAYLSVVEALRHACIEQKALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCCCCCCC
NGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDASSSELDPKTPNPVIHLLPE
CCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKI
CCCHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEE
SGTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN
ECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA