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The map label for this gene is gcvT

Identifier: 78780165

GI number: 78780165

Start: 1671418

End: 1672530

Strand: Direct

Name: gcvT

Synonym: PMT9312_1780

Alternate gene names: 78780165

Gene position: 1671418-1672530 (Clockwise)

Preceding gene: 78780164

Following gene: 78780166

Centisome position: 97.79

GC content: 31.81

Gene sequence:

>1113_bases
ATGGATTTGCTTAAAAGTCCTTTATATGCAAAATATGTTCAATCCAATGCAAAATTAGTGGATTTTGCAGGTTGGGAAAT
GCCCATATCATTTTCAGGATTAATCAAAGAGCATGAATCAGTTAGGTCTTCAGTAGGATTGTTTGATATTTCTCACATGG
GTGTAATCTCTATTAAGGGAATCAATCCAAAGGATTATATTCAAAAATTTTTTCCTACTAATTTATACTCCTTTTCTGAA
GGTCAGGGGCTTTATACAGTAATGCTCAATGAAAAAGGAGGAATAATAGATGACTTAATAATTTATGACCTTGGTATACA
AGACAATGACATATCAGAAGTATTGTTAATAGTTAACGCAAGTAGATATGAAGTAGATTTTCAATGGATAAAAAACAATT
CAAATAAATATGAAATTTCGATAACAAACTTTAAAAAAGACAAAGTACTTTTAGCACTACAGGGGAAAAACTCATTCGAT
TTATTTGAACAATGGATTGAATCATCGATCTCACATATCCCTAACTTTGGATGCGAATATAAAATTTTCGAACATATTTC
TCCTAAAGAAAAAATCTTCGTTTCCAAGACAGGATATACAGGGGAAAATGGTCTAGAAATACTTTTATCTAAAAAAGCAG
CAATTAATTTATGGGATTTCTCAATTTCCAAAAATGTTGCGCCTTGTGGTTTAGGAGCTAGAGATACTCTTAGACTTGAA
GCAGGCATGCATCTTTATGGCCAAGACATTAATGAAGAAACTTCTCCATATGAAGCAGGGTTAGGCTGGCTAGTACATCT
AGAAAATAATCACGAATTCTTTGGAAGAAGATTTCTTGAAGAGCAGTCAAGATTAGGTATTCAAAAAAAGTTAGTTGGTC
TCTTTATAGAAGGTAAAGCAATAGGAAGAAAAGGTTGCATAGTACTTAAAGGTGAAGAAAATATTGGAACTATCACTAGC
GGCAGTTGGTCTCCAACTAAACAACAAGCTATAGCTTTTGCATACATCAATACTTCGCATGCCTTAATAAATAATGAAGT
TCAAATACTAATAAGAGGCAAAAAATTCAAAGGTTGCATAACAAAAAGATCGTTTTATAAAAAGAATTATTAA

Upstream 100 bases:

>100_bases
CAGCCAAAGTACTTAGAAGCTTAATTTTGTCATTAGAAAATATGCAATAAAAAATTTCTAAACTAAAGTGTAAAAATACT
AAATTAAAATTAAATATTTC

Downstream 100 bases:

>100_bases
CTAAATTTACCCTTAAAGAATTATTATAAGTTATTGATCAATAAATCATACTTAGATGAGAAACAAAATTTGTGATGAAC
TCAATAATACAGATATTGGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MDLLKSPLYAKYVQSNAKLVDFAGWEMPISFSGLIKEHESVRSSVGLFDISHMGVISIKGINPKDYIQKFFPTNLYSFSE
GQGLYTVMLNEKGGIIDDLIIYDLGIQDNDISEVLLIVNASRYEVDFQWIKNNSNKYEISITNFKKDKVLLALQGKNSFD
LFEQWIESSISHIPNFGCEYKIFEHISPKEKIFVSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKAIGRKGCIVLKGEENIGTITS
GSWSPTKQQAIAFAYINTSHALINNEVQILIRGKKFKGCITKRSFYKKNY

Sequences:

>Translated_370_residues
MDLLKSPLYAKYVQSNAKLVDFAGWEMPISFSGLIKEHESVRSSVGLFDISHMGVISIKGINPKDYIQKFFPTNLYSFSE
GQGLYTVMLNEKGGIIDDLIIYDLGIQDNDISEVLLIVNASRYEVDFQWIKNNSNKYEISITNFKKDKVLLALQGKNSFD
LFEQWIESSISHIPNFGCEYKIFEHISPKEKIFVSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKAIGRKGCIVLKGEENIGTITS
GSWSPTKQQAIAFAYINTSHALINNEVQILIRGKKFKGCITKRSFYKKNY
>Mature_370_residues
MDLLKSPLYAKYVQSNAKLVDFAGWEMPISFSGLIKEHESVRSSVGLFDISHMGVISIKGINPKDYIQKFFPTNLYSFSE
GQGLYTVMLNEKGGIIDDLIIYDLGIQDNDISEVLLIVNASRYEVDFQWIKNNSNKYEISITNFKKDKVLLALQGKNSFD
LFEQWIESSISHIPNFGCEYKIFEHISPKEKIFVSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKAIGRKGCIVLKGEENIGTITS
GSWSPTKQQAIAFAYINTSHALINNEVQILIRGKKFKGCITKRSFYKKNY

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=28.7234042553192, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796258, Length=347, Percent_Identity=29.3948126801153, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=26.5415549597855, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI257796256, Length=304, Percent_Identity=28.6184210526316, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24797151, Length=349, Percent_Identity=23.4957020057307, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=35.2941176470588, Blast_Score=227, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=31.2335958005249, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71994052, Length=380, Percent_Identity=23.4210526315789, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71994045, Length=380, Percent_Identity=23.4210526315789, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI32563613, Length=348, Percent_Identity=24.7126436781609, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=27.8772378516624, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20129441, Length=396, Percent_Identity=30.3030303030303, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI20130091, Length=363, Percent_Identity=21.2121212121212, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41843; Mature: 41843

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLKSPLYAKYVQSNAKLVDFAGWEMPISFSGLIKEHESVRSSVGLFDISHMGVISIKG
CCCCCCCHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEC
INPKDYIQKFFPTNLYSFSEGQGLYTVMLNEKGGIIDDLIIYDLGIQDNDISEVLLIVNA
CCHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEEEC
SRYEVDFQWIKNNSNKYEISITNFKKDKVLLALQGKNSFDLFEQWIESSISHIPNFGCEY
CEEEEEEEEEECCCCEEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
KIFEHISPKEKIFVSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLE
EHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCEEEEE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHEEEEEEEECEE
IGRKGCIVLKGEENIGTITSGSWSPTKQQAIAFAYINTSHALINNEVQILIRGKKFKGCI
CCCCCEEEEECCCCCCEEECCCCCCCHHCEEEEEEEECCCEEECCCEEEEEECCCCCCCH
TKRSFYKKNY
HHHHHHCCCC
>Mature Secondary Structure
MDLLKSPLYAKYVQSNAKLVDFAGWEMPISFSGLIKEHESVRSSVGLFDISHMGVISIKG
CCCCCCCHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEC
INPKDYIQKFFPTNLYSFSEGQGLYTVMLNEKGGIIDDLIIYDLGIQDNDISEVLLIVNA
CCHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEEEC
SRYEVDFQWIKNNSNKYEISITNFKKDKVLLALQGKNSFDLFEQWIESSISHIPNFGCEY
CEEEEEEEEEECCCCEEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
KIFEHISPKEKIFVSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLE
EHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCEEEEE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHEEEEEEEECEE
IGRKGCIVLKGEENIGTITSGSWSPTKQQAIAFAYINTSHALINNEVQILIRGKKFKGCI
CCCCCEEEEECCCCCCEEECCCCCCCHHCEEEEEEEECCCEEECCCEEEEEECCCCCCCH
TKRSFYKKNY
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA