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The map label for this gene is fumC

Identifier: 78779943

GI number: 78779943

Start: 1451132

End: 1452517

Strand: Direct

Name: fumC

Synonym: PMT9312_1559

Alternate gene names: 78779943

Gene position: 1451132-1452517 (Clockwise)

Preceding gene: 78779942

Following gene: 78779945

Centisome position: 84.9

GC content: 31.96

Gene sequence:

>1386_bases
ATGACAAAAAACTTTAGGATTGAAAAAGATAGTATGGGAACTATAAAGGTTCCCATAGAAGCTTTGTGGGGAGCTCAAAC
ACAAAGATCGATAATAAATTTTTCTATTGGAGAAGAATTAATTCCAATTGAGTTAATTTATTCACTAACCCTCATAAAAA
AAGCTGCTTCAATTGCGAATTTCAATTTAGGTTTAATCGATAAAAGAAAAAAAGATTTGATTGTAGAGGCATGTACAGAA
ATACTTGATGGGATTCATGATTCACAGTTTCCCTTAAAAGTTTGGCAAACAGGCAGTGGCACGCAAACAAATATGAATGT
AAATGAGGTAATTTCAAATATTGCAGCATTAAGAACAAATTCAGAGCTTGGTAGTCATCAACCAATTCATCCGAATGATG
ATGTAAATAAATCTCAGTCAACTAATGATACTTTTCCTGCTGCTATTCAAATATCTGTTGTTAATGAAATAATCAAAAAT
TTAGTTCCAACGATAAGAGAACTTACGAAGATCCTTGATAAAAAAAGTGAAGAATGGAAAGACCTTATAAAGATAGGAAG
AACCCATTTTCAAGATGCAGTGCCCCTTACTTTTGGGCAAGAAATATCAGGATGGTCAGAGCAACTTAAAGATGCTGAGA
ATGCAATTATTATGAGCCTAAATGAATTGTATTTCTTACCTCTGGGAGGAACTGCAGTTGGTACAGGGATTAATTGTCCA
AAAGGATTTTGTGAAGAGGCAATAAAATCAATTTCCGATGATACTAATCTAATGTTCTATAAATCAAAAAATAATTTTTC
TATCATGGCCTCGCATGATCGTCTAGCTCAAGTAATGAGTCAGATAAAAATATTAGCAGGTGCATTATTTAAAATTTCAA
ATGATATAAAAATTCTATCTTCTGGTCCAAGATCAGGAATATATGAATTAATTATCCCTCAAAATGAACCTGGAAGTTCT
ATCATGCCGGGCAAAGTGAATCCGACTCAATGCGAAGCCTTATCAATGGTTTGCACTCAGATAATGGGTCTTGAATATGC
AGTTTCAATGGCAAATTCTAGCGGTACTTTACAGATGAATGAATATAAGCCTTTGATTGGATTTAATATTCTTACAAGTT
TAAAATTACTTAAAAATGCAATAGAAAACTTTAGAATAAAATTAGTTGATGGGATGGAACCTAATCAAAAGAAAATGAAG
TTAAATTTAGAAAATTCACTAATGTTGGTTACAGCCATAGTGCCAAAAGTTGGTTATGAAAAAGCAGCTGAAATTGCAAA
CCTTGCCTTCAAAGAATCACTAAATTTAAAAGAGGCAACACTTAAATTAGGTTATTTAAACGAAGATGAATTTGATGAAG
CAATGAATATTAATTCAATGATTTGA

Upstream 100 bases:

>100_bases
TTCAATTCATCTCAATAATTTAAGTGTAATATGGGAGAAGTTAGGTATCTAGGATTACTGAAAACCTTATCTAAGTTAAA
CCAGTGTTTTCAGAGGAATA

Downstream 100 bases:

>100_bases
TAAAAATTTAAGAATTATTGTCAATTCTTTTTGTTGCAGGATTAATATCTTCAGAGACTTTTATAAGATCATTTGATTCA
GAAACAGGAAAACGATTAAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGIHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALRTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKILDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
KGFCEEAIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRIKLVDGMEPNQKKMK
LNLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDEAMNINSMI

Sequences:

>Translated_461_residues
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGIHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALRTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKILDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
KGFCEEAIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRIKLVDGMEPNQKKMK
LNLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDEAMNINSMI
>Mature_460_residues
TKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTEI
LDGIHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALRTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNL
VPTIRELTKILDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCPK
GFCEEAIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSSI
MPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRIKLVDGMEPNQKKMKL
NLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDEAMNINSMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=48.0434782608696, Blast_Score=426, Evalue=1e-119,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=48.6842105263158, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI87082375, Length=466, Percent_Identity=37.3390557939914, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=48.471615720524, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=46.9135802469136, Blast_Score=305, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324993, Length=455, Percent_Identity=46.5934065934066, Blast_Score=428, Evalue=1e-121,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=48.8069414316703, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=48.3801295896328, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=48.3801295896328, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=46.7391304347826, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=43.2608695652174, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51037; Mature: 50906

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCCEEECCCCCEEEECHHHHHCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGIHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALRTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
SELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKILDKKSEEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEEEECCCCEECCCCCCC
KGFCEEAIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNAIENFRIKLVDGMEPNQKKMKLNLENSLMLVTAIVPKVGYE
CCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHEEEECCCCEEEEEHHHCCCCHH
KAAEIANLAFKESLNLKEATLKLGYLNEDEFDEAMNINSMI
HHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCEEECCCCCEEEECHHHHHCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGIHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALRTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
SELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKILDKKSEEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEEEECCCCEECCCCCCC
KGFCEEAIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNAIENFRIKLVDGMEPNQKKMKLNLENSLMLVTAIVPKVGYE
CCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHEEEECCCCEEEEEHHHCCCCHH
KAAEIANLAFKESLNLKEATLKLGYLNEDEFDEAMNINSMI
HHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]