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The map label for this gene is bioF [H]

Identifier: 78779945

GI number: 78779945

Start: 1455391

End: 1456530

Strand: Direct

Name: bioF [H]

Synonym: PMT9312_1561

Alternate gene names: 78779945

Gene position: 1455391-1456530 (Clockwise)

Preceding gene: 78779943

Following gene: 78779946

Centisome position: 85.15

GC content: 32.81

Gene sequence:

>1140_bases
ATGAAAAAAATAAAAATTCCAAAAAATAGAACCCGTAAATTAAAAACATTTTCTTTAGGTAAAAAACCCTTCGAACTTCT
AAGTTTAAATTCTCATAATAAAAAACTTATAGACTTATGCAGTAATGATTATTTTGGATTAAGTAGGGATAAGGATTTAA
TAAAAGCTGCTTACGAAATAAGCCTATTAGAAGGTATTGGTTCTGGAAGCTCTAGGTTTATTACAGGTTCAAGACCAATA
CATGAATTATTAGAGACAGAACTTGCCGAGTGGCTTGATCAACAGAAAGTATTACTTTTCCCAAGCGGATTTCAAGCAAA
TATAGCCGCTATCCAGGCTTTAGCAAACAGAAATAGTATCGTAATAGCTGATAAATTGATTCATAACTCTTTATTAGTGG
GAGTCAAAGCTGCTCAAGCAAAACTGGTTCGATTTTCACACAATAATTTAAAAGATTTAGAAGAAAAAATTATTAAATTT
AACCCTAAAAAAAATTCCATTTTAGTTGTTGTTGAATCTCTTTACAGCATGGAGGGATCAATAGCTCCGCTCAGAGAAAT
TTCAGAAATTTGCAAAAAAAATAGTGTTCAATTATTAGTTGACGAAGCCCATGCAATTGGGATATTGGGCCCTGAAGGTA
GGGGGTTAAGTTTTAATTTACGTTCGGATATAACTATGATTACTGGAACTTTTGGGAAAGCATTTGGAAGCGGTGGAGCT
TTCATAGCATCCAATTCAGAGATTGGTGAATATCTTATCCAAACAAGTGGTGCATTTAGGTATACAACTGCACTCGCTCC
ATCTTTAGCTGCTGGGGCACTAGAAGGTTTGAAAAAAATTTTAAAAAATAAAGAATGGGGTAATGATTTGTTATCTTCTG
CGAAGGTATGGAAAGATGAAATTATTAGAAATTTTAGTTTTCCAGTTCAAGGAGATGCTCACATTTTATCAATTATTGTT
GGACAAGAAGAGAATGCTATTTATCTACAAAAATATCTCGAAAAAAATGGGTTCCTAGCAGTTGCAATAAGACCTCCAAC
TGTTCCAGTTGGGCAATCAAGAATCAGAATAACAATAAGAAGAAACTTAGATCTTAATCTGCTAAAGCATTTCATTGCAG
TATTAAAAGAGTTTAAATGA

Upstream 100 bases:

>100_bases
TATGATCTATATAAATATTAATAAACAAAAAATACCTTGCAAACTTTAATAGTAAATCTAAATCTTTCTAATTAAATCCA
ATATATGTTATTTTGCCAAA

Downstream 100 bases:

>100_bases
AACAAATTATTACTCAACATGGGTGGGGACTAAATCAACATTTCTGGGATGATTATAAAATTGATTTTTTAAAAAATAAT
TGGCATTGGCAAGATAATGA

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKKIKIPKNRTRKLKTFSLGKKPFELLSLNSHNKKLIDLCSNDYFGLSRDKDLIKAAYEISLLEGIGSGSSRFITGSRPI
HELLETELAEWLDQQKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKAAQAKLVRFSHNNLKDLEEKIIKF
NPKKNSILVVVESLYSMEGSIAPLREISEICKKNSVQLLVDEAHAIGILGPEGRGLSFNLRSDITMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILKNKEWGNDLLSSAKVWKDEIIRNFSFPVQGDAHILSIIV
GQEENAIYLQKYLEKNGFLAVAIRPPTVPVGQSRIRITIRRNLDLNLLKHFIAVLKEFK

Sequences:

>Translated_379_residues
MKKIKIPKNRTRKLKTFSLGKKPFELLSLNSHNKKLIDLCSNDYFGLSRDKDLIKAAYEISLLEGIGSGSSRFITGSRPI
HELLETELAEWLDQQKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKAAQAKLVRFSHNNLKDLEEKIIKF
NPKKNSILVVVESLYSMEGSIAPLREISEICKKNSVQLLVDEAHAIGILGPEGRGLSFNLRSDITMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILKNKEWGNDLLSSAKVWKDEIIRNFSFPVQGDAHILSIIV
GQEENAIYLQKYLEKNGFLAVAIRPPTVPVGQSRIRITIRRNLDLNLLKHFIAVLKEFK
>Mature_379_residues
MKKIKIPKNRTRKLKTFSLGKKPFELLSLNSHNKKLIDLCSNDYFGLSRDKDLIKAAYEISLLEGIGSGSSRFITGSRPI
HELLETELAEWLDQQKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKAAQAKLVRFSHNNLKDLEEKIIKF
NPKKNSILVVVESLYSMEGSIAPLREISEICKKNSVQLLVDEAHAIGILGPEGRGLSFNLRSDITMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILKNKEWGNDLLSSAKVWKDEIIRNFSFPVQGDAHILSIIV
GQEENAIYLQKYLEKNGFLAVAIRPPTVPVGQSRIRITIRRNLDLNLLKHFIAVLKEFK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=345, Percent_Identity=32.463768115942, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI83977444, Length=345, Percent_Identity=32.463768115942, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI83977440, Length=345, Percent_Identity=32.463768115942, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI284448556, Length=338, Percent_Identity=28.1065088757396, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI7657118, Length=328, Percent_Identity=28.3536585365854, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4502025, Length=342, Percent_Identity=30.1169590643275, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI40316939, Length=342, Percent_Identity=30.1169590643275, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4758668, Length=352, Percent_Identity=30.6818181818182, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=28.3783783783784, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI5454084, Length=249, Percent_Identity=28.1124497991968, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786993, Length=356, Percent_Identity=33.4269662921348, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790046, Length=332, Percent_Identity=30.7228915662651, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=338, Percent_Identity=28.4023668639053, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566772, Length=348, Percent_Identity=28.735632183908, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=247, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=247, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982617, Length=259, Percent_Identity=26.6409266409266, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=256, Percent_Identity=26.5625, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=368, Percent_Identity=29.6195652173913, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=358, Percent_Identity=26.8156424581006, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24662918, Length=337, Percent_Identity=28.1899109792285, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=29.4617563739377, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI17136286, Length=350, Percent_Identity=28, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653280, Length=318, Percent_Identity=24.5283018867925, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653276, Length=318, Percent_Identity=24.5283018867925, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653278, Length=318, Percent_Identity=24.5283018867925, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41952; Mature: 41952

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKIPKNRTRKLKTFSLGKKPFELLSLNSHNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SLLEGIGSGSSRFITGSRPIHELLETELAEWLDQQKVLLFPSGFQANIAAIQALANRNSI
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKAAQAKLVRFSHNNLKDLEEKIIKFNPKKNSILVVVESLYSMEGS
EEEHHHHHHHHHEEEHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCC
IAPLREISEICKKNSVQLLVDEAHAIGILGPEGRGLSFNLRSDITMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCEEEECCCCEEEEEECHHHHHCCCCE
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILKNKEWGNDLLSSAKVWKDE
EEECCCHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIRNFSFPVQGDAHILSIIVGQEENAIYLQKYLEKNGFLAVAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDLNLLKHFIAVLKEFK
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIKIPKNRTRKLKTFSLGKKPFELLSLNSHNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SLLEGIGSGSSRFITGSRPIHELLETELAEWLDQQKVLLFPSGFQANIAAIQALANRNSI
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKAAQAKLVRFSHNNLKDLEEKIIKFNPKKNSILVVVESLYSMEGS
EEEHHHHHHHHHEEEHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCC
IAPLREISEICKKNSVQLLVDEAHAIGILGPEGRGLSFNLRSDITMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCEEEECCCCEEEEEECHHHHHCCCCE
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILKNKEWGNDLLSSAKVWKDE
EEECCCHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIRNFSFPVQGDAHILSIIVGQEENAIYLQKYLEKNGFLAVAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDLNLLKHFIAVLKEFK
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA