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The map label for this gene is kduD [H]

Identifier: 78779734

GI number: 78779734

Start: 1265645

End: 1266403

Strand: Direct

Name: kduD [H]

Synonym: PMT9312_1350

Alternate gene names: 78779734

Gene position: 1265645-1266403 (Clockwise)

Preceding gene: 78779733

Following gene: 78779735

Centisome position: 74.05

GC content: 29.91

Gene sequence:

>759_bases
ATGAGTATGTTTTCTGTAAAAAATAAACGTGTATTAGTCGTGGGGGCCTCTAGGGGGATTGGTCTTGAAATATCAATCAA
ATTGAAAGAGGGAAAAGCTGATATTCTTGGAATTGCTAGGTCTGATATAAATGCTGATTTTAATTATCTAAGAGTTGATA
TCTCAAACAATAAAGATATCTTATATTTAAATAAATATATCGAGCAAAATAACTTATTTTTTGATGGAATTGTCGTAAAT
TCAGCAATAAGTCAATCTCCCAAAACATTTGATAATAAAGAAAACACTTCTAATAAGCAGAAATTTACACAAAACCCTAG
GAAGTTTGAATTAATTAATAATATAAATCTAATTTCTGTTTATGAACTTCTATATACTGTAAGTCCTTATATTTCGAAAG
ATGCTTCAATTATTTTTATCTCTAGTATTGGTTCTGAATTGGGATTCCCAGGGAATCCTGGATACCAAACATCAAAAGCA
GGAATAAACGCCTTAGTGAGAGCATTAGCTGTAGATTTATCTAGAGATAGAATAAGAGTGAACCATTTAAATTTAGGATA
TATAAATGCACCAATGAGTAAGGATTCATACAATGATAAAAAAATGAATAAAGAAAGAAGTGAAAGAACAATCCTAAAAA
GGTGGGGCTCTATAGAAGATGTAATAGGACCAGTAATTTTTTTATTATCTAATGAAAGTAGCTATATCACTGGAACAGGT
ATAAATGTTGATGGTGGGTGGTTATCAAAAGGATTATGA

Upstream 100 bases:

>100_bases
AGGGATATGTAAAATGGACAAATTAAAAATGTTCCAAATAGATCACTATAGTGATATTTTTATTGTAGAAAAAATCTTGC
AGAAACTCAATATCAAATAA

Downstream 100 bases:

>100_bases
ATTTAGATTTAAAAGATAAATTTATAATAATAGCTGGAGGACTTGGGGGTATTGGTCTAGAAACTGTAAAAGACTTAATT
TCTGAAGGTGCAGAAATTTC

Product: 2-deoxy-D-gluconate 3-dehydrogenase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSMFSVKNKRVLVVGASRGIGLEISIKLKEGKADILGIARSDINADFNYLRVDISNNKDILYLNKYIEQNNLFFDGIVVN
SAISQSPKTFDNKENTSNKQKFTQNPRKFELINNINLISVYELLYTVSPYISKDASIIFISSIGSELGFPGNPGYQTSKA
GINALVRALAVDLSRDRIRVNHLNLGYINAPMSKDSYNDKKMNKERSERTILKRWGSIEDVIGPVIFLLSNESSYITGTG
INVDGGWLSKGL

Sequences:

>Translated_252_residues
MSMFSVKNKRVLVVGASRGIGLEISIKLKEGKADILGIARSDINADFNYLRVDISNNKDILYLNKYIEQNNLFFDGIVVN
SAISQSPKTFDNKENTSNKQKFTQNPRKFELINNINLISVYELLYTVSPYISKDASIIFISSIGSELGFPGNPGYQTSKA
GINALVRALAVDLSRDRIRVNHLNLGYINAPMSKDSYNDKKMNKERSERTILKRWGSIEDVIGPVIFLLSNESSYITGTG
INVDGGWLSKGL
>Mature_251_residues
SMFSVKNKRVLVVGASRGIGLEISIKLKEGKADILGIARSDINADFNYLRVDISNNKDILYLNKYIEQNNLFFDGIVVNS
AISQSPKTFDNKENTSNKQKFTQNPRKFELINNINLISVYELLYTVSPYISKDASIIFISSIGSELGFPGNPGYQTSKAG
INALVRALAVDLSRDRIRVNHLNLGYINAPMSKDSYNDKKMNKERSERTILKRWGSIEDVIGPVIFLLSNESSYITGTGI
NVDGGWLSKGL

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=27.0992366412214, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=25.1012145748988, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI15277342, Length=111, Percent_Identity=39.6396396396396, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40254992, Length=112, Percent_Identity=39.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790717, Length=264, Percent_Identity=26.5151515151515, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=25.1937984496124, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082160, Length=265, Percent_Identity=23.7735849056604, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=24.7191011235955, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=26.6932270916335, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787905, Length=259, Percent_Identity=28.1853281853282, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=28.2442748091603, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=27.7992277992278, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=25.6809338521401, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=262, Percent_Identity=24.4274809160305, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=26.171875, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=239, Percent_Identity=25.9414225941423, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=145, Percent_Identity=30.3448275862069, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=28.6259541984733, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=24.7011952191235, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=27.734375, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571526, Length=266, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=26.5384615384615, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 28082; Mature: 27951

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMFSVKNKRVLVVGASRGIGLEISIKLKEGKADILGIARSDINADFNYLRVDISNNKDI
CCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCEEEEEEECCCCCE
LYLNKYIEQNNLFFDGIVVNSAISQSPKTFDNKENTSNKQKFTQNPRKFELINNINLISV
EEEEEEECCCCEEEEEEEEEHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHH
YELLYTVSPYISKDASIIFISSIGSELGFPGNPGYQTSKAGINALVRALAVDLSRDRIRV
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
NHLNLGYINAPMSKDSYNDKKMNKERSERTILKRWGSIEDVIGPVIFLLSNESSYITGTG
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCEEEEEEECCCCEEEECC
INVDGGWLSKGL
CCCCCCHHCCCC
>Mature Secondary Structure 
SMFSVKNKRVLVVGASRGIGLEISIKLKEGKADILGIARSDINADFNYLRVDISNNKDI
CCCCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCEEEEEEECCCCCE
LYLNKYIEQNNLFFDGIVVNSAISQSPKTFDNKENTSNKQKFTQNPRKFELINNINLISV
EEEEEEECCCCEEEEEEEEEHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHH
YELLYTVSPYISKDASIIFISSIGSELGFPGNPGYQTSKAGINALVRALAVDLSRDRIRV
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
NHLNLGYINAPMSKDSYNDKKMNKERSERTILKRWGSIEDVIGPVIFLLSNESSYITGTG
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCEEEEEEECCCCEEEECC
INVDGGWLSKGL
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]