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The map label for this gene is hemK [H]

Identifier: 78484733

GI number: 78484733

Start: 437555

End: 438394

Strand: Reverse

Name: hemK [H]

Synonym: Tcr_0388

Alternate gene names: 78484733

Gene position: 438394-437555 (Counterclockwise)

Preceding gene: 78484734

Following gene: 78484732

Centisome position: 18.06

GC content: 49.4

Gene sequence:

>840_bases
ATGCGAATTGATGAGGCTTTAACTGCGGCGAAGCAACAGCTGAAAGCCGCCTCCTCCGACAGCATTGCGCTGGACGCGGA
ACTGCTGTTGAGCTTTGTCCTTCAAAAAAACCGTACTTACCTTTACACCTGGCCTGAAAAACCACTTTCCGAAGCCGAGC
ACACTCAGTATTTCGACCTCACCTCTCGTCGAGTCGAGGGTCACCCTATTGCTCATTTAATTGGCCACCGAGAGTTTTGG
GGAATGGATTTTCAAGTCACGCCAGACACTCTCATTCCTCGACCAGACACCGAAATCTTAGTCGAAACCGCCTTGGAAAT
CATGGCCTCTAAAAACAACCAGGCCTGGTCATTTTTAGATTTGGGAACGGGGTCTGGCGCGATTGCCTGTGCCATCAAAG
CCAGCCACCCTGCTTGCGAAGCAACGGCCGTCGATTTTCAAGCCAGTGCATTGGCGGTGGCTCAACAAAATGCCAACCAA
CATCATTTGACGATTCACTTCAAACAAGGAAGCTGGTTTGATCCTGTTAAAGGGCAGACGTTTGATTTAATCGTTTCCAA
CCCGCCTTACATTGAAGAACATGATCCGCATTTAAAAGAGGGCGATGTTCGCTTTGAACCTCTCACAGCCTTAACGTCCG
GAGAAGATGGACTGGACGACATCCGCTTCATTATCGAACACGCGCCCACTTATTTAAAACCGAAAGGCTGGCTCCTCATC
GAACATGGCTACAATCAGCATGAAGCCGTGCAACGCTTATTTAAAGCACAAGGTTTCACAGCGGTTGAGTCTCGATTGGA
TTACGGGCAAAACCCCAGAGTGACCTTAGGGCAACGTTAG

Upstream 100 bases:

>100_bases
AAGTGGTTGACCCTTTGATTAACGAATATCAAGCTGAACAACTGGCAGCACTTAGCGAAGACAGTGCTTAAGCGACCTAA
GCCATTAAAAGAGAGGCGGC

Downstream 100 bases:

>100_bases
CACATACCTGCTTGTTCACTCACATTGTTGTAAAATACACGCAGTACTGCACACAACGAAACAAAAAGAATGCTTATGAA
CACTTTAAAAACCGAACTAA

Product: HemK family modification methylase

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MRIDEALTAAKQQLKAASSDSIALDAELLLSFVLQKNRTYLYTWPEKPLSEAEHTQYFDLTSRRVEGHPIAHLIGHREFW
GMDFQVTPDTLIPRPDTEILVETALEIMASKNNQAWSFLDLGTGSGAIACAIKASHPACEATAVDFQASALAVAQQNANQ
HHLTIHFKQGSWFDPVKGQTFDLIVSNPPYIEEHDPHLKEGDVRFEPLTALTSGEDGLDDIRFIIEHAPTYLKPKGWLLI
EHGYNQHEAVQRLFKAQGFTAVESRLDYGQNPRVTLGQR

Sequences:

>Translated_279_residues
MRIDEALTAAKQQLKAASSDSIALDAELLLSFVLQKNRTYLYTWPEKPLSEAEHTQYFDLTSRRVEGHPIAHLIGHREFW
GMDFQVTPDTLIPRPDTEILVETALEIMASKNNQAWSFLDLGTGSGAIACAIKASHPACEATAVDFQASALAVAQQNANQ
HHLTIHFKQGSWFDPVKGQTFDLIVSNPPYIEEHDPHLKEGDVRFEPLTALTSGEDGLDDIRFIIEHAPTYLKPKGWLLI
EHGYNQHEAVQRLFKAQGFTAVESRLDYGQNPRVTLGQR
>Mature_279_residues
MRIDEALTAAKQQLKAASSDSIALDAELLLSFVLQKNRTYLYTWPEKPLSEAEHTQYFDLTSRRVEGHPIAHLIGHREFW
GMDFQVTPDTLIPRPDTEILVETALEIMASKNNQAWSFLDLGTGSGAIACAIKASHPACEATAVDFQASALAVAQQNANQ
HHLTIHFKQGSWFDPVKGQTFDLIVSNPPYIEEHDPHLKEGDVRFEPLTALTSGEDGLDDIRFIIEHAPTYLKPKGWLLI
EHGYNQHEAVQRLFKAQGFTAVESRLDYGQNPRVTLGQR

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=280, Percent_Identity=30.7142857142857, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787463, Length=273, Percent_Identity=49.0842490842491, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI87082085, Length=199, Percent_Identity=37.1859296482412, Blast_Score=104, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24582226, Length=268, Percent_Identity=28.7313432835821, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31268; Mature: 31268

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDEALTAAKQQLKAASSDSIALDAELLLSFVLQKNRTYLYTWPEKPLSEAEHTQYFDL
CCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCCCCHHHCCEEEEC
TSRRVEGHPIAHLIGHREFWGMDFQVTPDTLIPRPDTEILVETALEIMASKNNQAWSFLD
CCCCCCCCCHHHHHCCHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
LGTGSGAIACAIKASHPACEATAVDFQASALAVAQQNANQHHLTIHFKQGSWFDPVKGQT
ECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCE
FDLIVSNPPYIEEHDPHLKEGDVRFEPLTALTSGEDGLDDIRFIIEHAPTYLKPKGWLLI
EEEEECCCCCCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCEECCCCEEEE
EHGYNQHEAVQRLFKAQGFTAVESRLDYGQNPRVTLGQR
ECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure
MRIDEALTAAKQQLKAASSDSIALDAELLLSFVLQKNRTYLYTWPEKPLSEAEHTQYFDL
CCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCCEEEEECCCCCCCHHHCCEEEEC
TSRRVEGHPIAHLIGHREFWGMDFQVTPDTLIPRPDTEILVETALEIMASKNNQAWSFLD
CCCCCCCCCHHHHHCCHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEE
LGTGSGAIACAIKASHPACEATAVDFQASALAVAQQNANQHHLTIHFKQGSWFDPVKGQT
ECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCE
FDLIVSNPPYIEEHDPHLKEGDVRFEPLTALTSGEDGLDDIRFIIEHAPTYLKPKGWLLI
EEEEECCCCCCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCEECCCCEEEE
EHGYNQHEAVQRLFKAQGFTAVESRLDYGQNPRVTLGQR
ECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]