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The map label for this gene is moeB [H]

Identifier: 78484732

GI number: 78484732

Start: 436712

End: 437485

Strand: Reverse

Name: moeB [H]

Synonym: Tcr_0387

Alternate gene names: 78484732

Gene position: 437485-436712 (Counterclockwise)

Preceding gene: 78484733

Following gene: 78484727

Centisome position: 18.02

GC content: 46.12

Gene sequence:

>774_bases
ATGCTTATGAACACTTTAAAAACCGAACTAAATGATGAAGAACTTTCCCGCTACAGTCGTCAAATCCTGTTATCTGAAAT
CGATTATGCCGGCCAGCTGAAACTTGCACAATCACATGCCGTTATTTTTGGTTTAGGCGGTTTGGGATCACCCGCTTCTT
TGTATCTGGCTTCTGCCGGTGTTGGTACTTTGACACTGGTGGATTTTGATGAGGTGGACGATTCAAACCTGCAACGTCAA
GTCATCCACCGTGAGGCCAACATTGGACAGCCTAAAGTGCTTTCCGCGAAAGAAAATTTACAAGCGCTGAACCACCATAT
CGACATCCATACGGTGAACCACAAATTGGATGAAACTGAACTTGAAGCGTTGATCCAATCGGCTGATATTGTGCTGGATT
GTACCGATAATTTTGAAAGCCGATTTGCCTTGAACCGCGTTTGTCTCAAGCAAAAGAAACCGTTGGTTTCCGGTGCCGCC
ATTCGCTGGGAAGGCCAATTAACCACCTATGATTTTCGTCAGGAAGACAGCCCCTGCTATCAGTGTTTATACAAAGAAGG
ACAGGGACAAGAGCTCACCTGCAGTCAGAATGGCGTTGTCGCCCCAATGGTAGGAATGGTCGGTTCAATGCAAGCCATGG
AGGCAATTAAAGCTTTGATTGGACTGCCTACTTTGGTGGGAAAACTGATGATTATGGATGGCGTCACCATGCAAATCCGG
ACCTTAAAGCTGTCTAAAGATCCAGACTGCAAAACTTGCCATCCCCCTCACTAA

Upstream 100 bases:

>100_bases
AAACCCCAGAGTGACCTTAGGGCAACGTTAGCACATACCTGCTTGTTCACTCACATTGTTGTAAAATACACGCAGTACTG
CACACAACGAAACAAAAAGA

Downstream 100 bases:

>100_bases
TTCACACCGCTATCACTGTTGATAGCGGTAATCAAAGGTTGGTTTAGCGGACTGCGGTTGTTCTGCTCGCTGTTTTTGAG
ATTTCTTATTCACCAGAATA

Product: UBA/THIF-type NAD/FAD binding fold protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MLMNTLKTELNDEELSRYSRQILLSEIDYAGQLKLAQSHAVIFGLGGLGSPASLYLASAGVGTLTLVDFDEVDDSNLQRQ
VIHREANIGQPKVLSAKENLQALNHHIDIHTVNHKLDETELEALIQSADIVLDCTDNFESRFALNRVCLKQKKPLVSGAA
IRWEGQLTTYDFRQEDSPCYQCLYKEGQGQELTCSQNGVVAPMVGMVGSMQAMEAIKALIGLPTLVGKLMIMDGVTMQIR
TLKLSKDPDCKTCHPPH

Sequences:

>Translated_257_residues
MLMNTLKTELNDEELSRYSRQILLSEIDYAGQLKLAQSHAVIFGLGGLGSPASLYLASAGVGTLTLVDFDEVDDSNLQRQ
VIHREANIGQPKVLSAKENLQALNHHIDIHTVNHKLDETELEALIQSADIVLDCTDNFESRFALNRVCLKQKKPLVSGAA
IRWEGQLTTYDFRQEDSPCYQCLYKEGQGQELTCSQNGVVAPMVGMVGSMQAMEAIKALIGLPTLVGKLMIMDGVTMQIR
TLKLSKDPDCKTCHPPH
>Mature_257_residues
MLMNTLKTELNDEELSRYSRQILLSEIDYAGQLKLAQSHAVIFGLGGLGSPASLYLASAGVGTLTLVDFDEVDDSNLQRQ
VIHREANIGQPKVLSAKENLQALNHHIDIHTVNHKLDETELEALIQSADIVLDCTDNFESRFALNRVCLKQKKPLVSGAA
IRWEGQLTTYDFRQEDSPCYQCLYKEGQGQELTCSQNGVVAPMVGMVGSMQAMEAIKALIGLPTLVGKLMIMDGVTMQIR
TLKLSKDPDCKTCHPPH

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=232, Percent_Identity=40.0862068965517, Blast_Score=168, Evalue=5e-42,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=52.6315789473684, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI87082356, Length=244, Percent_Identity=43.4426229508197, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1789177, Length=124, Percent_Identity=29.0322580645161, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540406, Length=248, Percent_Identity=38.3064516129032, Blast_Score=196, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI193203301, Length=156, Percent_Identity=27.5641025641026, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=249, Percent_Identity=35.7429718875502, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322639, Length=163, Percent_Identity=30.6748466257669, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582879, Length=253, Percent_Identity=41.897233201581, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24660640, Length=162, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28353; Mature: 28353

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMNTLKTELNDEELSRYSRQILLSEIDYAGQLKLAQSHAVIFGLGGLGSPASLYLASAG
CCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCHHEEEEECC
VGTLTLVDFDEVDDSNLQRQVIHREANIGQPKVLSAKENLQALNHHIDIHTVNHKLDETE
CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHEEEEEEECCCCCHHH
LEALIQSADIVLDCTDNFESRFALNRVCLKQKKPLVSGAAIRWEGQLTTYDFRQEDSPCY
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCHHH
QCLYKEGQGQELTCSQNGVVAPMVGMVGSMQAMEAIKALIGLPTLVGKLMIMDGVTMQIR
HHHHHCCCCCEEEECCCCEEHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEE
TLKLSKDPDCKTCHPPH
EEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLMNTLKTELNDEELSRYSRQILLSEIDYAGQLKLAQSHAVIFGLGGLGSPASLYLASAG
CCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCHHEEEEECC
VGTLTLVDFDEVDDSNLQRQVIHREANIGQPKVLSAKENLQALNHHIDIHTVNHKLDETE
CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHEEEEEEECCCCCHHH
LEALIQSADIVLDCTDNFESRFALNRVCLKQKKPLVSGAAIRWEGQLTTYDFRQEDSPCY
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCHHH
QCLYKEGQGQELTCSQNGVVAPMVGMVGSMQAMEAIKALIGLPTLVGKLMIMDGVTMQIR
HHHHHCCCCCEEEECCCCEEHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEE
TLKLSKDPDCKTCHPPH
EEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]