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The map label for this gene is ung [H]

Identifier: 78484707

GI number: 78484707

Start: 410938

End: 411636

Strand: Reverse

Name: ung [H]

Synonym: Tcr_0362

Alternate gene names: 78484707

Gene position: 411636-410938 (Counterclockwise)

Preceding gene: 78484708

Following gene: 78484706

Centisome position: 16.96

GC content: 44.64

Gene sequence:

>699_bases
ATGCCGAATCAAAACATCCAATTAGATGAATCTTGGCTCAATGTCATTGGCGAAGAGTTTGAAAAGCCGTATATGCAGCA
ACTTAAAACCTTTTTGTTAGCTGAAAAGGCGGCCGGCAAAGAAATATTGCCCAAAGCTAAGCTTTGGTTTAATGCGCTGA
ACAGCACACCGTTTGAAGACGTCAAGGTGGTTATTTTGGGACAAGACCCTTACCCTACGCCAGGACATGCGCATGGGCTG
AGTTTTTCCGTGTTGCCGGACGTAAAACCACTTCCAAAATCGTTGCTTAATATCAACAAAGAACTGCTTGACGACTTGAA
TATAGACAATACTCACTGCGGGTATTTGCAACCTTGGGCCGACCAAGGGGTTTTGTTGCTCAATGCGGTGCTCACCGTTG
AAGCCGGCAAAGCCAATGCGCACCAAAACAAAGGCTGGGAACAATTCACTGATGCCGTGATTCACGCCTTGGCCACACAA
CGCCAACATATTGTTTTTATCCTTTGGGGCGCTTATGCACAAAAAAAAGGGAAAATCATCAATCCGGCTCACCACTTTAT
ACTAAAAAGCCCACATCCTTCTCCTTTATCAGCCTACCGAGGCTTCTTTGGCAGCAAGCCTTTTTCCAAGACAAATCAAT
ATCTTTCCGAGCATAACATCCCTCATATAAATTGGCAGCTGCCGAATAAAATCTTTTGA

Upstream 100 bases:

>100_bases
TACATGATCGTTTTCGCTATCAACGTCTTTCAAAAAACGACCAGGCCTGGCAAATTACTCGGTTAAACCCTTAATTCAGA
TGAAACCAATAGAGGCTTTT

Downstream 100 bases:

>100_bases
TATAAAAGGCTCTAAAAATCATTAGAATGACTTCCTCAAGTAAATATAAATAATAATTTTTTGCACTTAGGAACTTTTTG
AATGAAAAAGCCAACGCTTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MPNQNIQLDESWLNVIGEEFEKPYMQQLKTFLLAEKAAGKEILPKAKLWFNALNSTPFEDVKVVILGQDPYPTPGHAHGL
SFSVLPDVKPLPKSLLNINKELLDDLNIDNTHCGYLQPWADQGVLLLNAVLTVEAGKANAHQNKGWEQFTDAVIHALATQ
RQHIVFILWGAYAQKKGKIINPAHHFILKSPHPSPLSAYRGFFGSKPFSKTNQYLSEHNIPHINWQLPNKIF

Sequences:

>Translated_232_residues
MPNQNIQLDESWLNVIGEEFEKPYMQQLKTFLLAEKAAGKEILPKAKLWFNALNSTPFEDVKVVILGQDPYPTPGHAHGL
SFSVLPDVKPLPKSLLNINKELLDDLNIDNTHCGYLQPWADQGVLLLNAVLTVEAGKANAHQNKGWEQFTDAVIHALATQ
RQHIVFILWGAYAQKKGKIINPAHHFILKSPHPSPLSAYRGFFGSKPFSKTNQYLSEHNIPHINWQLPNKIF
>Mature_231_residues
PNQNIQLDESWLNVIGEEFEKPYMQQLKTFLLAEKAAGKEILPKAKLWFNALNSTPFEDVKVVILGQDPYPTPGHAHGLS
FSVLPDVKPLPKSLLNINKELLDDLNIDNTHCGYLQPWADQGVLLLNAVLTVEAGKANAHQNKGWEQFTDAVIHALATQR
QHIVFILWGAYAQKKGKIINPAHHFILKSPHPSPLSAYRGFFGSKPFSKTNQYLSEHNIPHINWQLPNKIF

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=226, Percent_Identity=49.5575221238938, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI19718751, Length=226, Percent_Identity=49.5575221238938, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=50, Blast_Score=208, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=45.8715596330275, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6323620, Length=224, Percent_Identity=43.3035714285714, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26184; Mature: 26053

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNQNIQLDESWLNVIGEEFEKPYMQQLKTFLLAEKAAGKEILPKAKLWFNALNSTPFED
CCCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCC
VKVVILGQDPYPTPGHAHGLSFSVLPDVKPLPKSLLNINKELLDDLNIDNTHCGYLQPWA
EEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCC
DQGVLLLNAVLTVEAGKANAHQNKGWEQFTDAVIHALATQRQHIVFILWGAYAQKKGKII
CCCEEEEHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCCEE
NPAHHFILKSPHPSPLSAYRGFFGSKPFSKTNQYLSEHNIPHINWQLPNKIF
CHHHHEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCC
>Mature Secondary Structure 
PNQNIQLDESWLNVIGEEFEKPYMQQLKTFLLAEKAAGKEILPKAKLWFNALNSTPFED
CCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCC
VKVVILGQDPYPTPGHAHGLSFSVLPDVKPLPKSLLNINKELLDDLNIDNTHCGYLQPWA
EEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCC
DQGVLLLNAVLTVEAGKANAHQNKGWEQFTDAVIHALATQRQHIVFILWGAYAQKKGKII
CCCEEEEHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCCEE
NPAHHFILKSPHPSPLSAYRGFFGSKPFSKTNQYLSEHNIPHINWQLPNKIF
CHHHHEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]