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The map label for this gene is pdxH1

Identifier: 78484708

GI number: 78484708

Start: 411663

End: 412313

Strand: Reverse

Name: pdxH1

Synonym: Tcr_0363

Alternate gene names: 78484708

Gene position: 412313-411663 (Counterclockwise)

Preceding gene: 78484720

Following gene: 78484707

Centisome position: 16.98

GC content: 45.78

Gene sequence:

>651_bases
ATGCCAAATAGAGATTATCACGCTGAAAGACGTGAATATGGATTTGCCGCTCTAAGACGAGCAGACTTGCAAACCGACCC
GTTTCACCAGTTTTCTGACTGGATGGAAACCGCGCTTGAAAAAACACAACAAGATGCCACCGCCATGAGCGTTTCAACCG
TCAGTGCGGATGGACAACCGCATAGTCGCATTGTGTTATTAAAAACATTCAATTCAGACGGATTTATTTTTTATACACAC
TATGACAGCGATAAAGGCCAACAAATCGATCAAAATGCCAAAGCGGCTTTATTGTTCTTCTGGCCAGAACTGGATCGACA
AATTCGAATTGAAGGTTCTCTGCAAAAAGTGCCTCGTGAAACCTCGGAAGCCTATTTTCACAGTCGCCCAAAAGACAGCC
AGCTTGCAGCTTCCATCTCCAACCAGAGTCAACCGGTTGCCAGCCGAGATATTTTAGAAGCCAAACTGCAAGAAGCCATG
TCACTGCCCGATCGGAATTTAACCTGCCCGGCTCACTGGGGAGGCTATCAACTTAAACCGTGTTATTTTGAGTTTTGGCA
AGGGCGTCCCAGCCGATTACATGATCGTTTTCGCTATCAACGTCTTTCAAAAAACGACCAGGCCTGGCAAATTACTCGGT
TAAACCCTTAA

Upstream 100 bases:

>100_bases
TAGTTTTCGCTCACGTATGGGAACTCCTGGTGGTAAGAAAATTTAAGTTGAGTTATATTACCCCGTAACTTAAAAGGATT
CAAACAGGAACGTCCTACCT

Downstream 100 bases:

>100_bases
TTCAGATGAAACCAATAGAGGCTTTTATGCCGAATCAAAACATCCAATTAGATGAATCTTGGCTCAATGTCATTGGCGAA
GAGTTTGAAAAGCCGTATAT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase 1; PNPOx 1; Pyridoxal 5'-phosphate synthase 1

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MPNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQPHSRIVLLKTFNSDGFIFYTH
YDSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRETSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAM
SLPDRNLTCPAHWGGYQLKPCYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP

Sequences:

>Translated_216_residues
MPNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQPHSRIVLLKTFNSDGFIFYTH
YDSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRETSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAM
SLPDRNLTCPAHWGGYQLKPCYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP
>Mature_215_residues
PNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQPHSRIVLLKTFNSDGFIFYTHY
DSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRETSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAMS
LPDRNLTCPAHWGGYQLKPCYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=44.9438202247191, Blast_Score=169, Evalue=1e-42,
Organism=Escherichia coli, GI1787926, Length=208, Percent_Identity=44.7115384615385, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17553712, Length=199, Percent_Identity=43.21608040201, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319509, Length=217, Percent_Identity=38.7096774193548, Blast_Score=148, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45551845, Length=207, Percent_Identity=39.6135265700483, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644901, Length=207, Percent_Identity=39.6135265700483, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24644903, Length=170, Percent_Identity=27.6470588235294, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH1_THICR (Q31IR4)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390633.1
- HSSP:   P65682
- ProteinModelPortal:   Q31IR4
- SMR:   Q31IR4
- STRING:   Q31IR4
- GeneID:   3762349
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0363
- NMPDR:   fig|317025.3.peg.332
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   DYWGGYI
- PhylomeDB:   Q31IR4
- BioCyc:   TCRU317025:TCR_0363-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25160; Mature: 25029

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 63-63 BINDING 66-66 BINDING 68-68 BINDING 85-85 BINDING 125-125 BINDING 129-129 BINDING 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQP
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCC
HSRIVLLKTFNSDGFIFYTHYDSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRE
CCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHCCCH
TSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAMSLPDRNLTCPAHWGGYQLKP
HHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
CYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure 
PNRDYHAERREYGFAALRRADLQTDPFHQFSDWMETALEKTQQDATAMSVSTVSADGQP
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCC
HSRIVLLKTFNSDGFIFYTHYDSDKGQQIDQNAKAALLFFWPELDRQIRIEGSLQKVPRE
CCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHCCCH
TSEAYFHSRPKDSQLAASISNQSQPVASRDILEAKLQEAMSLPDRNLTCPAHWGGYQLKP
HHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
CYFEFWQGRPSRLHDRFRYQRLSKNDQAWQITRLNP
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA