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The map label for this gene is uvrA [H]

Identifier: 78484669

GI number: 78484669

Start: 362276

End: 365083

Strand: Reverse

Name: uvrA [H]

Synonym: Tcr_0324

Alternate gene names: 78484669

Gene position: 365083-362276 (Counterclockwise)

Preceding gene: 78484670

Following gene: 78484668

Centisome position: 15.04

GC content: 47.9

Gene sequence:

>2808_bases
ATGCTAGAAGAGATTATTGTTCGGGGTGCTCGCACCCATAATTTGAAAAACATCGATGTCACACTTCCACGAGATAAATT
GATTGTGATCACCGGCCTATCTGGTTCGGGCAAGTCTTCACTAGCATTTGATACCATTTATGCAGAAGGTCAACGCCGCT
ATGTTGAATCGTTATCGGCCTACGCTCGTCAGTTTTTATCGGTTATGGAAAAGCCGGACATCGATCACATCGAAGGACTT
TCCCCTGCGATTTCAATAGAGCAAAAATCCACCTCTCACAACCCTCGCTCCACTGTCGGCACCGTGACCGAAATTTATGA
TTATTTGCGCCTACTGTATGCCCGTGCTGGAACACCGCGCTGCCCAACCCATAACAGCGACCTTGTTGCGCAAACCGTCA
GCCAGATGGTGGATCACACATTAGAACTACCTGAAGGCACCAAGTGTTTATTGATTGCTCCTGTCGTGCGAGGCAAAAAA
GGGGCTCATCAAAATTTATTAGATGAACTCCAAGCACAAGGTTATATTCGTGCGCGAATAGATGGCAAATTAATGGAGCT
GGATGGGTCGATTGAGCTGGATAAAAAATATAAGCACGACATTGAAGTGGTGGTGGATCGCTTCAAAGTTCGCCCGGACA
TCAAACAACGATTGGCTGAATCGTTTGAAACCGCATTGCATCTTGCGGATGGCATTGCCCAAGTCGTTCCAATGGATGAA
GAAGAGGATTTTCATTTACTATTTTCCGAGCGATTTTCCTGCCCACAATGCGGCTACTCCGTGCCGGAATTGGAACCGCG
TATTTTTTCATTCAACAACCCACATGGAGCCTGTCCAACCTGTGATGGGTTAGGGGTTAAGCAAAGCTTTGACCCGGAAC
GCGTGATTATGCACCCAGACTTGAGCCTAGCCGGTGGCGCCATTCGGGGTTGGGATCGACGCCATAAATACTATTATGAC
TTACTAAAGGCCGTAGCCGATTATTATCAGTTTGATATGGAAACTCCATGGTTGGAGCTGACGGAAGAGCAGCAAAATAT
CGTGCTCTATGGTTCTGGCAAAGAAAAGCTGCCTCTACCTCATGGACGCTATTCCGATACGCGCCGTTTTGAAGGCGTGA
TTCCAAACATGGAACGTCGGTTTACCGAAACGGACAGCAAAACCGTGCGTGACGAACTGGATAAATTTCGTGTTTCTCAC
GTCTGCAGTAGTTGCCATGGCGCTCGCTTAAATGAAGCGGCCCGCCACGTTTTCGTCGCCGACGAGACCTTGCCGGCGCT
AACAGAGCGCCCAATTGGCAACCTGTATGACTTGTTCAGCCAGCTGGAGCTGCAAGGCACCAAAGGTGAAATTGCGGAAA
AAATCATCAAAGAAGTATTTGACCGCCTATCCTTCTTAGTCAACGTGGGGTTGAACTATTTGACACTGAACCGAAGTGCG
GACACCCTTTCTGGTGGAGAAGCTCAGCGCATTAGACTCGCCAGTCAAATTGGGGCCGGACTGGTCGGGGTCATGTACGT
GTTAGACGAACCGTCAATCGGGTTGCACCAACGAGACAATGACCGCTTACTCAACACTCTGACTCGATTAAGAGATTTAG
GCAACACAGTCATTGTGGTGGAACATGATGAAGATGCGATTCGGGCCGCCGATTATGTCTTGGACATTGGACCGGGCGCC
GGGGTTCATGGAGGACGCATCATGGCACAAGGTACGCCAGAAGAAGTGATGCAAAACAAAGCCTCTTTAACCGGACAGTA
TTTGACAGGTGAAAAAGCCATTCAAACCCCCAAAAATCGTCTGCCACTACCGGATCATTGGCTGTCGATTTATGGCGCCT
CCGGTAACAATTTGCAAACCGTTGACTTGAAAATTCCGGCCGGACTGCTCACTTGTATTACAGGAGTTTCAGGCTCTGGA
AAATCAACGCTGATCAATGAAACTTTGTACAAAATTACCGCCAGCAAACTCAATAAAGCTTTATTAGAGCCGGCTCCTTA
TGAAAAAGTCACGGGCTTAGAGCATTTTGATAAAGTCGTCAATATTGACCAAAGCCCCATTGGCCGAACACCCCGTTCTA
ATCCAGCAACGTATACTGGGCTTTTTACGCCGATTCGTGAGTTGCTGTCAGCCACTCCAGAAGCTCGTACTCGAGGTTAC
ACACCAGGTCGTTTCAGCTTTAATGTTAAAGGCGGACGCTGCGAAGCTTGCCAAGGTGATGGTGTTTTGAAAGTCGAAAT
GCATTTCTTACCGGATGTGTATGTGGCGTGTGACGTCTGCCATGGCGCACGTTATAACCGTGAAACGTTGCAGGTCGATT
ACAAAGGTAAAAACATTCACGAAATTTTAGAAATGACCGTTGAAGATGCTCGCGCTTTCTTTGATGCCATCCCTGTGATT
GCCAGAAAGCTTCAAATGCTGCTAGAAGTGGGGCTAGGCTACATTAAGTTAGGACAAAGTGCGACCACGCTTTCAGGTGG
GGAGGCTCAACGAGTGAAGCTCGCGAAAGAACTGTCTAAACGTGATACTGGCAGCACACTTTACATACTCGATGAGCCGA
CCACAGGGCTGCATTTCCATGACATTGAATTACTCCTCAAAGTCATCCGAAACCTACGTGACCATGGCAACACCATCGTC
ATTATCGAACATAACCTCGATGTGATTAAAACCGCTGATTGGATTGTAGACCTCGGTCCTGAAGGTGGATCTGGAGGCGG
GCAAATTATTGCGACCGGCACGCCTGAAGAGGTGGCTGAAAATAAAGCATCCTATACCGGGCATTATTTGAAAAAGATTT
TGAGTTAA

Upstream 100 bases:

>100_bases
GCCAACGGCCTATTTTACAAAGGGATCGGACAGTGTCATTCCACGCTAGGGTTTTGTTATAATAAGACTTTTGCTTTCAT
AACCGACAGGCTAAACCCGC

Downstream 100 bases:

>100_bases
TTCATCTTATCTTACTGTCGGTTTAAAACAGCCAGGCCTGGCTGTTTTAAACCAATCAACCCAGACTGTATTCGAGGCCG
CTGAATGCAAAAATTAATTT

Product: excinuclease ABC, A subunit

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 935; Mature: 935

Protein sequence:

>935_residues
MLEEIIVRGARTHNLKNIDVTLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLSVMEKPDIDHIEGL
SPAISIEQKSTSHNPRSTVGTVTEIYDYLRLLYARAGTPRCPTHNSDLVAQTVSQMVDHTLELPEGTKCLLIAPVVRGKK
GAHQNLLDELQAQGYIRARIDGKLMELDGSIELDKKYKHDIEVVVDRFKVRPDIKQRLAESFETALHLADGIAQVVPMDE
EEDFHLLFSERFSCPQCGYSVPELEPRIFSFNNPHGACPTCDGLGVKQSFDPERVIMHPDLSLAGGAIRGWDRRHKYYYD
LLKAVADYYQFDMETPWLELTEEQQNIVLYGSGKEKLPLPHGRYSDTRRFEGVIPNMERRFTETDSKTVRDELDKFRVSH
VCSSCHGARLNEAARHVFVADETLPALTERPIGNLYDLFSQLELQGTKGEIAEKIIKEVFDRLSFLVNVGLNYLTLNRSA
DTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLNTLTRLRDLGNTVIVVEHDEDAIRAADYVLDIGPGA
GVHGGRIMAQGTPEEVMQNKASLTGQYLTGEKAIQTPKNRLPLPDHWLSIYGASGNNLQTVDLKIPAGLLTCITGVSGSG
KSTLINETLYKITASKLNKALLEPAPYEKVTGLEHFDKVVNIDQSPIGRTPRSNPATYTGLFTPIRELLSATPEARTRGY
TPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVACDVCHGARYNRETLQVDYKGKNIHEILEMTVEDARAFFDAIPVI
ARKLQMLLEVGLGYIKLGQSATTLSGGEAQRVKLAKELSKRDTGSTLYILDEPTTGLHFHDIELLLKVIRNLRDHGNTIV
IIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAENKASYTGHYLKKILS

Sequences:

>Translated_935_residues
MLEEIIVRGARTHNLKNIDVTLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLSVMEKPDIDHIEGL
SPAISIEQKSTSHNPRSTVGTVTEIYDYLRLLYARAGTPRCPTHNSDLVAQTVSQMVDHTLELPEGTKCLLIAPVVRGKK
GAHQNLLDELQAQGYIRARIDGKLMELDGSIELDKKYKHDIEVVVDRFKVRPDIKQRLAESFETALHLADGIAQVVPMDE
EEDFHLLFSERFSCPQCGYSVPELEPRIFSFNNPHGACPTCDGLGVKQSFDPERVIMHPDLSLAGGAIRGWDRRHKYYYD
LLKAVADYYQFDMETPWLELTEEQQNIVLYGSGKEKLPLPHGRYSDTRRFEGVIPNMERRFTETDSKTVRDELDKFRVSH
VCSSCHGARLNEAARHVFVADETLPALTERPIGNLYDLFSQLELQGTKGEIAEKIIKEVFDRLSFLVNVGLNYLTLNRSA
DTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLNTLTRLRDLGNTVIVVEHDEDAIRAADYVLDIGPGA
GVHGGRIMAQGTPEEVMQNKASLTGQYLTGEKAIQTPKNRLPLPDHWLSIYGASGNNLQTVDLKIPAGLLTCITGVSGSG
KSTLINETLYKITASKLNKALLEPAPYEKVTGLEHFDKVVNIDQSPIGRTPRSNPATYTGLFTPIRELLSATPEARTRGY
TPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVACDVCHGARYNRETLQVDYKGKNIHEILEMTVEDARAFFDAIPVI
ARKLQMLLEVGLGYIKLGQSATTLSGGEAQRVKLAKELSKRDTGSTLYILDEPTTGLHFHDIELLLKVIRNLRDHGNTIV
IIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAENKASYTGHYLKKILS
>Mature_935_residues
MLEEIIVRGARTHNLKNIDVTLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLSVMEKPDIDHIEGL
SPAISIEQKSTSHNPRSTVGTVTEIYDYLRLLYARAGTPRCPTHNSDLVAQTVSQMVDHTLELPEGTKCLLIAPVVRGKK
GAHQNLLDELQAQGYIRARIDGKLMELDGSIELDKKYKHDIEVVVDRFKVRPDIKQRLAESFETALHLADGIAQVVPMDE
EEDFHLLFSERFSCPQCGYSVPELEPRIFSFNNPHGACPTCDGLGVKQSFDPERVIMHPDLSLAGGAIRGWDRRHKYYYD
LLKAVADYYQFDMETPWLELTEEQQNIVLYGSGKEKLPLPHGRYSDTRRFEGVIPNMERRFTETDSKTVRDELDKFRVSH
VCSSCHGARLNEAARHVFVADETLPALTERPIGNLYDLFSQLELQGTKGEIAEKIIKEVFDRLSFLVNVGLNYLTLNRSA
DTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLNTLTRLRDLGNTVIVVEHDEDAIRAADYVLDIGPGA
GVHGGRIMAQGTPEEVMQNKASLTGQYLTGEKAIQTPKNRLPLPDHWLSIYGASGNNLQTVDLKIPAGLLTCITGVSGSG
KSTLINETLYKITASKLNKALLEPAPYEKVTGLEHFDKVVNIDQSPIGRTPRSNPATYTGLFTPIRELLSATPEARTRGY
TPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVACDVCHGARYNRETLQVDYKGKNIHEILEMTVEDARAFFDAIPVI
ARKLQMLLEVGLGYIKLGQSATTLSGGEAQRVKLAKELSKRDTGSTLYILDEPTTGLHFHDIELLLKVIRNLRDHGNTIV
IIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAENKASYTGHYLKKILS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=940, Percent_Identity=69.1489361702128, Blast_Score=1331, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 103752; Mature: 103752

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEEIIVRGARTHNLKNIDVTLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSA
CCHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH
YARQFLSVMEKPDIDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIYDYLRLLYARAGTPR
HHHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
CPTHNSDLVAQTVSQMVDHTLELPEGTKCLLIAPVVRGKKGAHQNLLDELQAQGYIRARI
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEE
DGKLMELDGSIELDKKYKHDIEVVVDRFKVRPDIKQRLAESFETALHLADGIAQVVPMDE
CCEEEEECCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEDFHLLFSERFSCPQCGYSVPELEPRIFSFNNPHGACPTCDGLGVKQSFDPERVIMHPD
CCCCEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCC
LSLAGGAIRGWDRRHKYYYDLLKAVADYYQFDMETPWLELTEEQQNIVLYGSGKEKLPLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCCCCCCC
HGRYSDTRRFEGVIPNMERRFTETDSKTVRDELDKFRVSHVCSSCHGARLNEAARHVFVA
CCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEE
DETLPALTERPIGNLYDLFSQLELQGTKGEIAEKIIKEVFDRLSFLVNVGLNYLTLNRSA
CCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
DTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLNTLTRLRDLGNTVIVV
CCCCCCCHHHHHHHHHHCCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
EHDEDAIRAADYVLDIGPGAGVHGGRIMAQGTPEEVMQNKASLTGQYLTGEKAIQTPKNR
ECCCHHHHHHHEEEECCCCCCCCCCEEEECCCHHHHHHHHHHCCCCEECCCHHHCCCCCC
LPLPDHWLSIYGASGNNLQTVDLKIPAGLLTCITGVSGSGKSTLINETLYKITASKLNKA
CCCCCHHHEEEECCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LLEPAPYEKVTGLEHFDKVVNIDQSPIGRTPRSNPATYTGLFTPIRELLSATPEARTRGY
HCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHCCC
TPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVACDVCHGARYNRETLQVDYKGKNIH
CCCEEEEEECCCEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCHH
EILEMTVEDARAFFDAIPVIARKLQMLLEVGLGYIKLGQSATTLSGGEAQRVKLAKELSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
RDTGSTLYILDEPTTGLHFHDIELLLKVIRNLRDHGNTIVIIEHNLDVIKTADWIVDLGP
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEEEEECC
EGGSGGGQIIATGTPEEVAENKASYTGHYLKKILS
CCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHC
>Mature Secondary Structure
MLEEIIVRGARTHNLKNIDVTLPRDKLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSA
CCHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH
YARQFLSVMEKPDIDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIYDYLRLLYARAGTPR
HHHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
CPTHNSDLVAQTVSQMVDHTLELPEGTKCLLIAPVVRGKKGAHQNLLDELQAQGYIRARI
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEE
DGKLMELDGSIELDKKYKHDIEVVVDRFKVRPDIKQRLAESFETALHLADGIAQVVPMDE
CCEEEEECCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEDFHLLFSERFSCPQCGYSVPELEPRIFSFNNPHGACPTCDGLGVKQSFDPERVIMHPD
CCCCEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCC
LSLAGGAIRGWDRRHKYYYDLLKAVADYYQFDMETPWLELTEEQQNIVLYGSGKEKLPLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCCCCCCC
HGRYSDTRRFEGVIPNMERRFTETDSKTVRDELDKFRVSHVCSSCHGARLNEAARHVFVA
CCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEE
DETLPALTERPIGNLYDLFSQLELQGTKGEIAEKIIKEVFDRLSFLVNVGLNYLTLNRSA
CCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
DTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLNTLTRLRDLGNTVIVV
CCCCCCCHHHHHHHHHHCCCCEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
EHDEDAIRAADYVLDIGPGAGVHGGRIMAQGTPEEVMQNKASLTGQYLTGEKAIQTPKNR
ECCCHHHHHHHEEEECCCCCCCCCCEEEECCCHHHHHHHHHHCCCCEECCCHHHCCCCCC
LPLPDHWLSIYGASGNNLQTVDLKIPAGLLTCITGVSGSGKSTLINETLYKITASKLNKA
CCCCCHHHEEEECCCCCEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LLEPAPYEKVTGLEHFDKVVNIDQSPIGRTPRSNPATYTGLFTPIRELLSATPEARTRGY
HCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHCCC
TPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVACDVCHGARYNRETLQVDYKGKNIH
CCCEEEEEECCCEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCHH
EILEMTVEDARAFFDAIPVIARKLQMLLEVGLGYIKLGQSATTLSGGEAQRVKLAKELSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
RDTGSTLYILDEPTTGLHFHDIELLLKVIRNLRDHGNTIVIIEHNLDVIKTADWIVDLGP
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEEEEECC
EGGSGGGQIIATGTPEEVAENKASYTGHYLKKILS
CCCCCCCEEEECCCHHHHHHCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]