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The map label for this gene is truC [H]

Identifier: 78484624

GI number: 78484624

Start: 326773

End: 327531

Strand: Reverse

Name: truC [H]

Synonym: Tcr_0279

Alternate gene names: 78484624

Gene position: 327531-326773 (Counterclockwise)

Preceding gene: 78484668

Following gene: 78484622

Centisome position: 13.49

GC content: 44.01

Gene sequence:

>759_bases
ATGCAAACAGACTGTCAACTCGACCAATTTAAAATACTGTATCAGGACGACTCCCTCGTCGCCGTTCATAAGCCCGCTGG
ACTACTTGTACACCGTTCGCCTATAGACCGTCATGAAACGCAGTTTGCCGTACAAATGACTCGGGATCAAATTAACCAAA
AAGTCTATCCCTTGCATCGCTTAGACAAAGCCACCTCGGGTTTATTACTGTTTGCACTTGATTCAAACACTGCACGATTA
ATGGGTCAGCAATTTGAAGAACACACCATCCAAAAGCACTATCTAGCAATATGCAGAGGCTGGACAGCTGAACACGGAGA
GATTGATCACGCATTGAAACACAAGCTAGACAAGCTGGGTGATCGCCATGCACAAACTAACAAACCGCCTCAAGAAGCCC
TAACAAATTTTGAGCGCCTGGCAACCACGGATGTGATGCACAAAATTGGAAAATTTGACTCTCAACGTTATTCTTTAGTC
AAGCTAATGCCAAAAACAGGGCGAAAACATCAACTTCGTCGACATTTAAACCACATCAGTCACCCGATCATTGGAGATGT
TAAATATGGTGATCGCCACCACAATCATTTTTTCAATACGTGGTTAGGCCAACACCGACTGTATCTAGCCGCCACAAGTT
TAACGTTCAACCACCCACAAACAAATGCACGGATGACACTGAACGCACCCCTTGAATTAAGCTATCAAAAAGCCACACAA
CATCTTAACTGGCAAGAAGAAACGGCCACTTACATATAA

Upstream 100 bases:

>100_bases
CTTTTCAGTAAAGCATCCAAAACCTCTTAAGGCTTTTTTGTATTTCAGCATAAGGTTTTGTTTAAAATGTGCAATCACTA
TGAAATAAGCGGTATTCAAT

Downstream 100 bases:

>100_bases
TTTAATGACCGCTTTATTTTGATTTAGTCGAATTGGCTGAGCCCATGCCAGCCATTCAGCTAATGAAGAGAGGCTTGAAA
ACGTAGCATGACCCCCATGT

Product: pseudouridine synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQTDCQLDQFKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLLLFALDSNTARL
MGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKPPQEALTNFERLATTDVMHKIGKFDSQRYSLV
KLMPKTGRKHQLRRHLNHISHPIIGDVKYGDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQ
HLNWQEETATYI

Sequences:

>Translated_252_residues
MQTDCQLDQFKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLLLFALDSNTARL
MGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKPPQEALTNFERLATTDVMHKIGKFDSQRYSLV
KLMPKTGRKHQLRRHLNHISHPIIGDVKYGDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQ
HLNWQEETATYI
>Mature_252_residues
MQTDCQLDQFKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLLLFALDSNTARL
MGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKPPQEALTNFERLATTDVMHKIGKFDSQRYSLV
KLMPKTGRKHQLRRHLNHISHPIIGDVKYGDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQ
HLNWQEETATYI

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI23308689, Length=183, Percent_Identity=28.9617486338798, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI221316667, Length=186, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI17158025, Length=140, Percent_Identity=32.8571428571429, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI221316663, Length=204, Percent_Identity=30.3921568627451, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789155, Length=236, Percent_Identity=48.3050847457627, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1787327, Length=236, Percent_Identity=31.3559322033898, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786244, Length=229, Percent_Identity=32.3144104803493, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788946, Length=239, Percent_Identity=25.9414225941423, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320168, Length=188, Percent_Identity=29.7872340425532, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324506, Length=183, Percent_Identity=30.0546448087432, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24583449, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583447, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583445, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921090, Length=182, Percent_Identity=31.3186813186813, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 29329; Mature: 29329

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDCQLDQFKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHR
CCCCCCCCCEEEEEECCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHH
LDKATSGLLLFALDSNTARLMGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLG
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
DRHAQTNKPPQEALTNFERLATTDVMHKIGKFDSQRYSLVKLMPKTGRKHQLRRHLNHIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
HPIIGDVKYGDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQ
CCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEEEEEECCCCCCCEEEECCCCEECHHHHHH
HLNWQEETATYI
CCCCCHHHCCCC
>Mature Secondary Structure
MQTDCQLDQFKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHR
CCCCCCCCCEEEEEECCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHH
LDKATSGLLLFALDSNTARLMGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLG
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
DRHAQTNKPPQEALTNFERLATTDVMHKIGKFDSQRYSLVKLMPKTGRKHQLRRHLNHIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
HPIIGDVKYGDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQ
CCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEEEEEECCCCCCCEEEECCCCEECHHHHHH
HLNWQEETATYI
CCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA