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The map label for this gene is mltC [H]

Identifier: 78484426

GI number: 78484426

Start: 101684

End: 102817

Strand: Reverse

Name: mltC [H]

Synonym: Tcr_0080

Alternate gene names: 78484426

Gene position: 102817-101684 (Counterclockwise)

Preceding gene: 78484427

Following gene: 78484425

Centisome position: 4.24

GC content: 46.91

Gene sequence:

>1134_bases
ATGAAACGTCGCCAATTTCTTGCCCTATTGTCCAGCACTGGATTGGTGTCCGCCTGCACCGTGACCGAAGTTCGGCGTGG
TATCAACTCGGCTCAACAACTCTCAAATGGTGATGTTCCGGGTGCTGTCAGCGCACAACTTCCTTCCAGCGGCATCGCAG
AAGTGGATCAACTGGTACGTCGTCAACTTAAAACCTTAATCCAGGAATTAGCGAAGACCTGGGGCGACAAAAAGGTAGCC
AGTCCTAAAGAATACGTTAAGTACACCGATCAATATCAAAGCCGAGCCATCGTCAACTTTAAAACCGGGCTGATCCGAGT
GGAGACGGTTGAACAAAAGTCCCCCAAAAGTGCGTTAAAAGCCGCCATCATCAGCACGCTTCTGACGCCGGAAAACCCCG
CCAAGGTCGACCTTTTATCCGATGAAGCGGTGACAACCGGTCAAAAACCTTTTTTACATGATTTGGTTATCGACCAAGAT
AAAAAAGCCGTCGGTACCCAGTGGCGTGCCAACCGTTATGCCGAGTATTTGATGAAGACCGCTTACAAAGTGGATTCTTA
TAACCAGAAAACACGCCATTATGTGACCTTTGCAATGGTCAAAGGTCACAACCAGACACAACAAAAGCACTATGCCACTC
AAGTGAAACGCCAGGGAAAACGCTTCAATATTGATCAAGCTTTGATCTATGCCATTATTGAAACCGAAAGCGCCTTTAAC
CCTTACGCCATGAGTCACATCCCGGCGTATGGACTGATGCAGATTGTGCCATCTTCGGCGGGGCGCGATGCTCATCGATT
GCTATACAAAAAAGACGGCATTCCGACCAAAAACTATCTCTTTCAGGCCGACAACAACATTGAGATGGGCACAGCGTATC
TTCATATCTTATTTACACGCTATTTGGCTCAAGTCAAAAACCCAAAAGCGCGGGAATATTGTTGCATTGCAGCCTACAAC
ACCGGCAGTGGTAATGTGCTTAAAGCGTTTGACACAGACCGCTCTAGAGCGTTTGATAAAATCAACACCTTAAGTGCTTC
CTCGGTTTACAGCCATTTGCGCAAACATCTGAAATATGAAGAAGCCCGTCACTATCTCTACAAAGTCACGCAAAAGAAAC
GCGCTTATGTTTAA

Upstream 100 bases:

>100_bases
AGAAGACACCCTAGAAACGGCCCTTGAAGCAAGCAAAAACCCCCAGGCCTGGTCTTTAGAAAAAGTGGCTAATTTACCCA
GCCGCTATTAAAGGAGAAAC

Downstream 100 bases:

>100_bases
CAAGCGTTTCAAGCTCTGAGGTTTCCTCAGAAAGCATGATTATCCCGAACAGATATTTTATAATACCTTTCATATTGACC
CTTTAAAGCCATGCTGGCAC

Product: lytic transglycosylase, catalytic

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKRRQFLALLSSTGLVSACTVTEVRRGINSAQQLSNGDVPGAVSAQLPSSGIAEVDQLVRRQLKTLIQELAKTWGDKKVA
SPKEYVKYTDQYQSRAIVNFKTGLIRVETVEQKSPKSALKAAIISTLLTPENPAKVDLLSDEAVTTGQKPFLHDLVIDQD
KKAVGTQWRANRYAEYLMKTAYKVDSYNQKTRHYVTFAMVKGHNQTQQKHYATQVKRQGKRFNIDQALIYAIIETESAFN
PYAMSHIPAYGLMQIVPSSAGRDAHRLLYKKDGIPTKNYLFQADNNIEMGTAYLHILFTRYLAQVKNPKAREYCCIAAYN
TGSGNVLKAFDTDRSRAFDKINTLSASSVYSHLRKHLKYEEARHYLYKVTQKKRAYV

Sequences:

>Translated_377_residues
MKRRQFLALLSSTGLVSACTVTEVRRGINSAQQLSNGDVPGAVSAQLPSSGIAEVDQLVRRQLKTLIQELAKTWGDKKVA
SPKEYVKYTDQYQSRAIVNFKTGLIRVETVEQKSPKSALKAAIISTLLTPENPAKVDLLSDEAVTTGQKPFLHDLVIDQD
KKAVGTQWRANRYAEYLMKTAYKVDSYNQKTRHYVTFAMVKGHNQTQQKHYATQVKRQGKRFNIDQALIYAIIETESAFN
PYAMSHIPAYGLMQIVPSSAGRDAHRLLYKKDGIPTKNYLFQADNNIEMGTAYLHILFTRYLAQVKNPKAREYCCIAAYN
TGSGNVLKAFDTDRSRAFDKINTLSASSVYSHLRKHLKYEEARHYLYKVTQKKRAYV
>Mature_377_residues
MKRRQFLALLSSTGLVSACTVTEVRRGINSAQQLSNGDVPGAVSAQLPSSGIAEVDQLVRRQLKTLIQELAKTWGDKKVA
SPKEYVKYTDQYQSRAIVNFKTGLIRVETVEQKSPKSALKAAIISTLLTPENPAKVDLLSDEAVTTGQKPFLHDLVIDQD
KKAVGTQWRANRYAEYLMKTAYKVDSYNQKTRHYVTFAMVKGHNQTQQKHYATQVKRQGKRFNIDQALIYAIIETESAFN
PYAMSHIPAYGLMQIVPSSAGRDAHRLLYKKDGIPTKNYLFQADNNIEMGTAYLHILFTRYLAQVKNPKAREYCCIAAYN
TGSGNVLKAFDTDRSRAFDKINTLSASSVYSHLRKHLKYEEARHYLYKVTQKKRAYV

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=312, Percent_Identity=40.3846153846154, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87081855, Length=156, Percent_Identity=39.1025641025641, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42662; Mature: 42662

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRQFLALLSSTGLVSACTVTEVRRGINSAQQLSNGDVPGAVSAQLPSSGIAEVDQLVR
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RQLKTLIQELAKTWGDKKVASPKEYVKYTDQYQSRAIVNFKTGLIRVETVEQKSPKSALK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCHHHHHH
AAIISTLLTPENPAKVDLLSDEAVTTGQKPFLHDLVIDQDKKAVGTQWRANRYAEYLMKT
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHCCHHHHHHHHHHHHHH
AYKVDSYNQKTRHYVTFAMVKGHNQTQQKHYATQVKRQGKRFNIDQALIYAIIETESAFN
HHHHCCCCCCHHEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
PYAMSHIPAYGLMQIVPSSAGRDAHRLLYKKDGIPTKNYLFQADNNIEMGTAYLHILFTR
CHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
YLAQVKNPKAREYCCIAAYNTGSGNVLKAFDTDRSRAFDKINTLSASSVYSHLRKHLKYE
HHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARHYLYKVTQKKRAYV
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRRQFLALLSSTGLVSACTVTEVRRGINSAQQLSNGDVPGAVSAQLPSSGIAEVDQLVR
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RQLKTLIQELAKTWGDKKVASPKEYVKYTDQYQSRAIVNFKTGLIRVETVEQKSPKSALK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCHHHHHH
AAIISTLLTPENPAKVDLLSDEAVTTGQKPFLHDLVIDQDKKAVGTQWRANRYAEYLMKT
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHCCHHHHHHHHHHHHHH
AYKVDSYNQKTRHYVTFAMVKGHNQTQQKHYATQVKRQGKRFNIDQALIYAIIETESAFN
HHHHCCCCCCHHEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
PYAMSHIPAYGLMQIVPSSAGRDAHRLLYKKDGIPTKNYLFQADNNIEMGTAYLHILFTR
CHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
YLAQVKNPKAREYCCIAAYNTGSGNVLKAFDTDRSRAFDKINTLSASSVYSHLRKHLKYE
HHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARHYLYKVTQKKRAYV
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA