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The map label for this gene is atoC [H]

Identifier: 78358638

GI number: 78358638

Start: 3556025

End: 3557404

Strand: Direct

Name: atoC [H]

Synonym: Dde_3599

Alternate gene names: 78358638

Gene position: 3556025-3557404 (Clockwise)

Preceding gene: 78358637

Following gene: 78358639

Centisome position: 95.33

GC content: 57.68

Gene sequence:

>1380_bases
ATGACCAACGACACGCATATTCTGCTTCTTGACGACGAAAAAAACTATCTTCTGGTGCTGGAAGCGCTGCTGACCGACGC
CGGATACAAGGTCACAGCCATCAACGACCCTGAAACCGGTCTGGCGTTTCTGGATGAATCGGATGTCGATGTCATCGTCA
CCGACATGAAAATGCCCAAAATCACCGGCCAGAACGTGCTTGACCATGTAAAAAAACGGTTTGCGCACATTCCGGTGCTC
ATCATGACTGCCTTCGGCTCCATAGAGGGCGCGGTGGAAGTGATGAAGACAGGGGCCTTCGACTACATCACCAAACCCTT
TTCCAACGATGAACTGCTGCTTTCTGTGCAGAACGCAGCAGAACTCGCCCTGGCGCACCGCCGCTACCGCCTGCTGGCTG
AAGCCATGGAGCAACGCTTTGGCCCGCGCCAGATAGTGGGCAACAGCCGCGCCATACGCGACGTGCTGACCATGGTGGAA
AGAGCCGCGCCCAGCAAGTCAACGGTGCTCATCACCGGAGAATCCGGCACCGGCAAAGAACTGGTGGCCCGTGCCATACA
TTATTCATCACCGCGCAAGGACGGCCCCTTCATCAGCGTCAACTGCATGGCGCTGAACGCCGGCGTGCTGGAAAGCGAAC
TGTTCGGCCACGAAAAAGGCTCGTTCACCGGCGCCACGGCCATGAAACGCGGCCGCTTTGAAATGGCGCACGGAGGAACG
CTTTTTCTGGATGAAATAGGCGAGCTTTCGCACGACATGCAGGTAAAGCTGCTGCGCGTGCTGCAGGAGCGCACATTTGA
GCGGGTGGGCGGCAGCGCCCCCATAGAAGTGGACATACGCGTGGTGGCCGCCACCAACAAAAACCTGCTTGAAGAGGTGG
GCAAAGGCAGCTTCCGCGAAGACCTGTACTACAGGCTCAACGTGGTGCAGGTGGAACTGCCGCCGCTGCGCGAACGCCGC
GAAGACATTCCGCTGCTGGCCGCGCATTTCGTGCACAAATATGCCGAGGACAACGAACTGCCGCAGAAGAACTTTTCTCC
TGAAGCGCTGGACTACCTGACCGGCTATGAATGGCCCGGCAACATCAGGCAGCTGGAAAACATCGTGGAACGCTGCATGG
TGCTTACGCCTTCGGCCACCATCGGCGTGGAAGACCTGCCCCATGAAATACGCGACGAGGAAACCCAGCTGAAAAGCGCC
GTGGACCTGCTTCCCGTCAAGCTGGATCTTGCCGACACACTGGACAAGCTGGAAGCGGCACTCATCCGCCGCGCGCTGGT
GCGGTCCGAATTCGTGCAGGTCAAGGCTGCGGAACTGCTGGGCATTTCTAAAAGTCTGCTGCAATACAAACTGAAAAAAT
ACGGCATCACAGGCCATTGA

Upstream 100 bases:

>100_bases
CATAATCACAAGCCATGAAGGCTCCATGGAACTGACCGATGCCCCGGAAGGCGGCGCCGAAGTGCGCGTTACCCTGCCCG
CGGCATAAGCGACGGATGCT

Downstream 100 bases:

>100_bases
TCTGTCATATTCCGTCATATCAGGGCCGGAACTCCGCACGGAGTTCCGGCCCTGACTGTTATGGCGGTCGTCACTGCCGG
TGCCGTCATGCCGCGGCAGT

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTNDTHILLLDDEKNYLLVLEALLTDAGYKVTAINDPETGLAFLDESDVDVIVTDMKMPKITGQNVLDHVKKRFAHIPVL
IMTAFGSIEGAVEVMKTGAFDYITKPFSNDELLLSVQNAAELALAHRRYRLLAEAMEQRFGPRQIVGNSRAIRDVLTMVE
RAAPSKSTVLITGESGTGKELVARAIHYSSPRKDGPFISVNCMALNAGVLESELFGHEKGSFTGATAMKRGRFEMAHGGT
LFLDEIGELSHDMQVKLLRVLQERTFERVGGSAPIEVDIRVVAATNKNLLEEVGKGSFREDLYYRLNVVQVELPPLRERR
EDIPLLAAHFVHKYAEDNELPQKNFSPEALDYLTGYEWPGNIRQLENIVERCMVLTPSATIGVEDLPHEIRDEETQLKSA
VDLLPVKLDLADTLDKLEAALIRRALVRSEFVQVKAAELLGISKSLLQYKLKKYGITGH

Sequences:

>Translated_459_residues
MTNDTHILLLDDEKNYLLVLEALLTDAGYKVTAINDPETGLAFLDESDVDVIVTDMKMPKITGQNVLDHVKKRFAHIPVL
IMTAFGSIEGAVEVMKTGAFDYITKPFSNDELLLSVQNAAELALAHRRYRLLAEAMEQRFGPRQIVGNSRAIRDVLTMVE
RAAPSKSTVLITGESGTGKELVARAIHYSSPRKDGPFISVNCMALNAGVLESELFGHEKGSFTGATAMKRGRFEMAHGGT
LFLDEIGELSHDMQVKLLRVLQERTFERVGGSAPIEVDIRVVAATNKNLLEEVGKGSFREDLYYRLNVVQVELPPLRERR
EDIPLLAAHFVHKYAEDNELPQKNFSPEALDYLTGYEWPGNIRQLENIVERCMVLTPSATIGVEDLPHEIRDEETQLKSA
VDLLPVKLDLADTLDKLEAALIRRALVRSEFVQVKAAELLGISKSLLQYKLKKYGITGH
>Mature_458_residues
TNDTHILLLDDEKNYLLVLEALLTDAGYKVTAINDPETGLAFLDESDVDVIVTDMKMPKITGQNVLDHVKKRFAHIPVLI
MTAFGSIEGAVEVMKTGAFDYITKPFSNDELLLSVQNAAELALAHRRYRLLAEAMEQRFGPRQIVGNSRAIRDVLTMVER
AAPSKSTVLITGESGTGKELVARAIHYSSPRKDGPFISVNCMALNAGVLESELFGHEKGSFTGATAMKRGRFEMAHGGTL
FLDEIGELSHDMQVKLLRVLQERTFERVGGSAPIEVDIRVVAATNKNLLEEVGKGSFREDLYYRLNVVQVELPPLRERRE
DIPLLAAHFVHKYAEDNELPQKNFSPEALDYLTGYEWPGNIRQLENIVERCMVLTPSATIGVEDLPHEIRDEETQLKSAV
DLLPVKLDLADTLDKLEAALIRRALVRSEFVQVKAAELLGISKSLLQYKLKKYGITGH

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=45.2954048140044, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1790437, Length=457, Percent_Identity=46.8271334792123, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=41.3276231263383, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1788905, Length=397, Percent_Identity=41.5617128463476, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI87082117, Length=245, Percent_Identity=55.5102040816327, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=43.0817610062893, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1789087, Length=357, Percent_Identity=44.2577030812325, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=44.0251572327044, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=42.9022082018927, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1787583, Length=314, Percent_Identity=39.4904458598726, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1786524, Length=382, Percent_Identity=37.696335078534, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=32.9032258064516, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789828, Length=271, Percent_Identity=34.3173431734317, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786784, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082012, Length=111, Percent_Identity=32.4324324324324, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51150; Mature: 51018

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDTHILLLDDEKNYLLVLEALLTDAGYKVTAINDPETGLAFLDESDVDVIVTDMKMPK
CCCCCEEEEEECCCCEEEHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEECCCCCC
ITGQNVLDHVKKRFAHIPVLIMTAFGSIEGAVEVMKTGAFDYITKPFSNDELLLSVQNAA
CCCHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEHHHH
ELALAHRRYRLLAEAMEQRFGPRQIVGNSRAIRDVLTMVERAAPSKSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LVARAIHYSSPRKDGPFISVNCMALNAGVLESELFGHEKGSFTGATAMKRGRFEMAHGGT
HHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCE
LFLDEIGELSHDMQVKLLRVLQERTFERVGGSAPIEVDIRVVAATNKNLLEEVGKGSFRE
EEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHCCCCHHH
DLYYRLNVVQVELPPLRERREDIPLLAAHFVHKYAEDNELPQKNFSPEALDYLTGYEWPG
HHEEEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
NIRQLENIVERCMVLTPSATIGVEDLPHEIRDEETQLKSAVDLLPVKLDLADTLDKLEAA
CHHHHHHHHHHHHEECCCCCCCHHHCCHHHCCHHHHHHHHHHHHEEEECHHHHHHHHHHH
LIRRALVRSEFVQVKAAELLGISKSLLQYKLKKYGITGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNDTHILLLDDEKNYLLVLEALLTDAGYKVTAINDPETGLAFLDESDVDVIVTDMKMPK
CCCCEEEEEECCCCEEEHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEECCCCCC
ITGQNVLDHVKKRFAHIPVLIMTAFGSIEGAVEVMKTGAFDYITKPFSNDELLLSVQNAA
CCCHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEHHHH
ELALAHRRYRLLAEAMEQRFGPRQIVGNSRAIRDVLTMVERAAPSKSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LVARAIHYSSPRKDGPFISVNCMALNAGVLESELFGHEKGSFTGATAMKRGRFEMAHGGT
HHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCE
LFLDEIGELSHDMQVKLLRVLQERTFERVGGSAPIEVDIRVVAATNKNLLEEVGKGSFRE
EEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHCCCCHHH
DLYYRLNVVQVELPPLRERREDIPLLAAHFVHKYAEDNELPQKNFSPEALDYLTGYEWPG
HHEEEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
NIRQLENIVERCMVLTPSATIGVEDLPHEIRDEETQLKSAVDLLPVKLDLADTLDKLEAA
CHHHHHHHHHHHHEECCCCCCCHHHCCHHHCCHHHHHHHHHHHHEEEECHHHHHHHHHHH
LIRRALVRSEFVQVKAAELLGISKSLLQYKLKKYGITGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]