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The map label for this gene is lysA [H]

Identifier: 78357706

GI number: 78357706

Start: 2676732

End: 2678036

Strand: Reverse

Name: lysA [H]

Synonym: Dde_2664

Alternate gene names: 78357706

Gene position: 2678036-2676732 (Counterclockwise)

Preceding gene: 78357707

Following gene: 78357696

Centisome position: 71.79

GC content: 58.77

Gene sequence:

>1305_bases
ATGTCGAACGTTCGTTCCGCCGTGACAGATGAACTGGATTTTTACGGGCTTTCCACACCCATGGAGCTGGTGGAAACCTA
TGGCAGCCCGCTGTACGTGTATAATGAAAACGTACTGCGCCGCAGATGCCGCGAATTGAAAGGGTTGAGCAGTCATCCGG
GGTTCCGGGTCAATTATTCGGCCAAGGCCAATGCCAATCTTTCGCTGCTGCGCATTATCCGTTCCGAAGGACTGGTGGTG
GATGCCATGTCTCCCGGCGAAATCGCCATGCATCTTGCGGCGGGATTCACGCCCGACGAAATAACCTACGTCTGCAACAA
CGTTTCTGCCGAAGAACTGCGCAATGCTGTCGATCACGGTCTGCTGGTCAGCGTGGACTCTCTGCCGCAGCTTGATCTGC
TGGGGCAGGTGAACCCCGGCGGCAAGGTGATGATCCGCATCAATCCCGGCATCGGCGCGGGACACCACAAAAAGGTTGTC
ACCGGCGGCAAGGAAACGAAATTCGGCATAGGGCCGGACGACGGCGATGCCGTGCGCCGCATTCTCAAGCGGCACAACCT
GACTCTTGCAGGGCTTAACCAGCACATCGGTTCGCTGTTCATGGAGCCGGACAGCTACATGGAAGCCGTGGAGTTTCTTC
TGCGCGAGGCGGAACAGTGGGATTCGCTGGAGGTCATCGACTTCGGCGGGGGATTCGGCATTCCGTACCGCAAATATGAA
AAACAGCCCCGGCTGGACATGGAAGCCACGGGCCGCATGCTGGATGACTGCATCGGCAGATGGGCGGAACGCACGGGATA
CAACGGACGCTTTATGATCGAGCCGGGCCGCTATGTGACCGCTGAGTGCGGCGTGGTACTGGGTACCGTGCATGCCGTCA
AAAACAACGGCGAACGCCGTTTTGCCGGTACAGATCTCGGGTTCAATGTTCTGCAGCGTCCGGTCATGTACGACGCTTTT
CATGATGTGGAGATATACCGCGAAGACGGTGTTCCGCAGCAGGAAACCATGCAGCAGACCATCGTGGGCAATATCTGCGA
ATCAGGCGATATCATGGCTGCCGCCCGCGAACTGCCCGAGATACAGGAAGGCGACATCATCGCCATGCTGGATGCCGGAG
CCTACGGTTTTGCCATGAGTTCCAGCTACAATCAGCGTCTGCGTCCGGCCGAAGTGCTGGTGGACAAAGACGGCCGCGAC
CGGCTTATCCGCCGCCGCGAAACTCTGGACGACCTGCTGGCCTGCTTTCCGGAGCATGCGGAAAAGACCGGCGGGTCTGT
GCGGGTGGCAGGCGGACGGGGCTAA

Upstream 100 bases:

>100_bases
ATCTGATGCGCGAGGCGCTGCTGAATGAAATTGAACTTATCAAGATCCGGTCCGGCATGAGCGGTGCAGAACCGGAGGAG
AGTCCCACAAGGGGGAAATA

Downstream 100 bases:

>100_bases
AGCATCCCGTCCACAAGCCGCTCCACGACGGCCAGAGCCTGCCGGGGCGGTGAATGAAAATCAGAAATATGCGGCACAAC
GCCGCTGACGGATATTCCGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNVRSAVTDELDFYGLSTPMELVETYGSPLYVYNENVLRRRCRELKGLSSHPGFRVNYSAKANANLSLLRIIRSEGLVV
DAMSPGEIAMHLAAGFTPDEITYVCNNVSAEELRNAVDHGLLVSVDSLPQLDLLGQVNPGGKVMIRINPGIGAGHHKKVV
TGGKETKFGIGPDDGDAVRRILKRHNLTLAGLNQHIGSLFMEPDSYMEAVEFLLREAEQWDSLEVIDFGGGFGIPYRKYE
KQPRLDMEATGRMLDDCIGRWAERTGYNGRFMIEPGRYVTAECGVVLGTVHAVKNNGERRFAGTDLGFNVLQRPVMYDAF
HDVEIYREDGVPQQETMQQTIVGNICESGDIMAAARELPEIQEGDIIAMLDAGAYGFAMSSSYNQRLRPAEVLVDKDGRD
RLIRRRETLDDLLACFPEHAEKTGGSVRVAGGRG

Sequences:

>Translated_434_residues
MSNVRSAVTDELDFYGLSTPMELVETYGSPLYVYNENVLRRRCRELKGLSSHPGFRVNYSAKANANLSLLRIIRSEGLVV
DAMSPGEIAMHLAAGFTPDEITYVCNNVSAEELRNAVDHGLLVSVDSLPQLDLLGQVNPGGKVMIRINPGIGAGHHKKVV
TGGKETKFGIGPDDGDAVRRILKRHNLTLAGLNQHIGSLFMEPDSYMEAVEFLLREAEQWDSLEVIDFGGGFGIPYRKYE
KQPRLDMEATGRMLDDCIGRWAERTGYNGRFMIEPGRYVTAECGVVLGTVHAVKNNGERRFAGTDLGFNVLQRPVMYDAF
HDVEIYREDGVPQQETMQQTIVGNICESGDIMAAARELPEIQEGDIIAMLDAGAYGFAMSSSYNQRLRPAEVLVDKDGRD
RLIRRRETLDDLLACFPEHAEKTGGSVRVAGGRG
>Mature_433_residues
SNVRSAVTDELDFYGLSTPMELVETYGSPLYVYNENVLRRRCRELKGLSSHPGFRVNYSAKANANLSLLRIIRSEGLVVD
AMSPGEIAMHLAAGFTPDEITYVCNNVSAEELRNAVDHGLLVSVDSLPQLDLLGQVNPGGKVMIRINPGIGAGHHKKVVT
GGKETKFGIGPDDGDAVRRILKRHNLTLAGLNQHIGSLFMEPDSYMEAVEFLLREAEQWDSLEVIDFGGGFGIPYRKYEK
QPRLDMEATGRMLDDCIGRWAERTGYNGRFMIEPGRYVTAECGVVLGTVHAVKNNGERRFAGTDLGFNVLQRPVMYDAFH
DVEIYREDGVPQQETMQQTIVGNICESGDIMAAARELPEIQEGDIIAMLDAGAYGFAMSSSYNQRLRPAEVLVDKDGRDR
LIRRRETLDDLLACFPEHAEKTGGSVRVAGGRG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=416, Percent_Identity=23.0769230769231, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789203, Length=403, Percent_Identity=35.2357320099256, Blast_Score=244, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=22.9281767955801, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47946; Mature: 47815

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVRSAVTDELDFYGLSTPMELVETYGSPLYVYNENVLRRRCRELKGLSSHPGFRVNYS
CCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEEC
AKANANLSLLRIIRSEGLVVDAMSPGEIAMHLAAGFTPDEITYVCNNVSAEELRNAVDHG
CCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHCCC
LLVSVDSLPQLDLLGQVNPGGKVMIRINPGIGAGHHKKVVTGGKETKFGIGPDDGDAVRR
EEEEECCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHH
ILKRHNLTLAGLNQHIGSLFMEPDSYMEAVEFLLREAEQWDSLEVIDFGGGFGIPYRKYE
HHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHC
KQPRLDMEATGRMLDDCIGRWAERTGYNGRFMIEPGRYVTAECGVVLGTVHAVKNNGERR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHCCCCEE
FAGTDLGFNVLQRPVMYDAFHDVEIYREDGVPQQETMQQTIVGNICESGDIMAAARELPE
EECCCCCHHHHHCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCC
IQEGDIIAMLDAGAYGFAMSSSYNQRLRPAEVLVDKDGRDRLIRRRETLDDLLACFPEHA
CCCCCEEEEEECCCCCEEECCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHCHHHH
EKTGGSVRVAGGRG
HHCCCEEEECCCCC
>Mature Secondary Structure 
SNVRSAVTDELDFYGLSTPMELVETYGSPLYVYNENVLRRRCRELKGLSSHPGFRVNYS
CCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEEC
AKANANLSLLRIIRSEGLVVDAMSPGEIAMHLAAGFTPDEITYVCNNVSAEELRNAVDHG
CCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHCCC
LLVSVDSLPQLDLLGQVNPGGKVMIRINPGIGAGHHKKVVTGGKETKFGIGPDDGDAVRR
EEEEECCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHH
ILKRHNLTLAGLNQHIGSLFMEPDSYMEAVEFLLREAEQWDSLEVIDFGGGFGIPYRKYE
HHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHC
KQPRLDMEATGRMLDDCIGRWAERTGYNGRFMIEPGRYVTAECGVVLGTVHAVKNNGERR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHCCCCEE
FAGTDLGFNVLQRPVMYDAFHDVEIYREDGVPQQETMQQTIVGNICESGDIMAAARELPE
EECCCCCHHHHHCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCC
IQEGDIIAMLDAGAYGFAMSSSYNQRLRPAEVLVDKDGRDRLIRRRETLDDLLACFPEHA
CCCCCEEEEEECCCCCEEECCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHCHHHH
EKTGGSVRVAGGRG
HHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]