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The map label for this gene is birA [H]

Identifier: 78357696

GI number: 78357696

Start: 2667956

End: 2668987

Strand: Reverse

Name: birA [H]

Synonym: Dde_2654

Alternate gene names: 78357696

Gene position: 2668987-2667956 (Counterclockwise)

Preceding gene: 78357706

Following gene: 78357693

Centisome position: 71.55

GC content: 64.83

Gene sequence:

>1032_bases
ATGGGTTTACAATTGGCTTTTCAGGAACAGGGAAAAGGCGGCGCTGTACGCGGCGCCATACTGGAAGTGCTGCGGAAGCA
TGACGGCAACTGGGTTTCCGGTGAGGAACTGAGCCGGATTCTGGGAATGTCGCGTGCTGCCGTTTCCAAGCACATGCGGC
TTATCCGCGACGCAGGGTACCCTGTGGAGGCCATGACCAGGCGGGGCTACCGGCTGGGAGGCGATGCGGACAGCCTGCAT
CCTGCAGCGGTATGCCACGGTCTGGGAACCCGGCTTTTGGGGCGGGGCACGGTGCTGCACATGGAGTCCGTGCCGTCAAC
CAACATGGAGGCCCGGGTGCTGGCGGAGCGCGGAGCACCAGAAGGGTCTGTGGTGCTGGCCGACTGCCAGACGGCGGGGC
GCGGGCGGCAGGGCCGGACATGGCTTTCGCCCCGCGGGGGGGTGTATATGTCTGTGGTGCTGCGCCCGCAGTGCGCCCCG
CAGCAGGTGCCCGTGCTGACCCTGATGACTGTGGTTGCCGTGGTGGGGGCGGTGCGCGGGCTTACGGGTCTGCCTGCAAT
GCCCAAATGGCCCAACGATGTGCTTGTGCATGGCCGCAAGCTGAGCGGTGTGCTTATTGAAGCAGGACTGGTTGTCGATG
CGCTGGACTATGCCGTTGCGGGCATAGGCATCAACGTGAATACCGTCTGTTCCGAGCTGGAGAGGGATGGTATGAGGGCT
GTTTCGCTGCGCGGGGCGCTTGAGACGCACCACGGTACGGAGCAGCCGCAGTTGCCCCGTGCGGGAGTGGCCCGCGCGGT
TCTTGAAGGGCTGGAAGAAGCTTATGAACTGTTCCGCAGCGGCGGCGGTGCCGCGGTGGTGGCCCGGTGGAAGCAGCTGG
CGGGCATAACCGGCAGCAGTATACGACTGGGCAGGGGGGATGCCGTGCTGACGGGAAAAGTCCGCGATGTGGATGACAAC
GGCTGGCTGCTGCTGGAAGATGAGAGCGGCACTGTTCACCGTCTGCCGGCAGGGGACATTCTGGACGGCTGA

Upstream 100 bases:

>100_bases
ATCCTTGCAGCGTGGCAGCATGTCAGGAAAGACCGCCCGGCGCGGTCAACGGCCGACTCCTAGCCTGCGTGACGGCTTAT
TGTCAACTTTTTAAGTTTAA

Downstream 100 bases:

>100_bases
TTGTTTTTACGGCTTCAGGACCGGCACGGGGCGCACCTCTGGTGCGCTTTTTTGTTTGGCTGTCCGCGTGCGGCAGCGCC
GGGGCATCAGACTGGCCGGA

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MGLQLAFQEQGKGGAVRGAILEVLRKHDGNWVSGEELSRILGMSRAAVSKHMRLIRDAGYPVEAMTRRGYRLGGDADSLH
PAAVCHGLGTRLLGRGTVLHMESVPSTNMEARVLAERGAPEGSVVLADCQTAGRGRQGRTWLSPRGGVYMSVVLRPQCAP
QQVPVLTLMTVVAVVGAVRGLTGLPAMPKWPNDVLVHGRKLSGVLIEAGLVVDALDYAVAGIGINVNTVCSELERDGMRA
VSLRGALETHHGTEQPQLPRAGVARAVLEGLEEAYELFRSGGGAAVVARWKQLAGITGSSIRLGRGDAVLTGKVRDVDDN
GWLLLEDESGTVHRLPAGDILDG

Sequences:

>Translated_343_residues
MGLQLAFQEQGKGGAVRGAILEVLRKHDGNWVSGEELSRILGMSRAAVSKHMRLIRDAGYPVEAMTRRGYRLGGDADSLH
PAAVCHGLGTRLLGRGTVLHMESVPSTNMEARVLAERGAPEGSVVLADCQTAGRGRQGRTWLSPRGGVYMSVVLRPQCAP
QQVPVLTLMTVVAVVGAVRGLTGLPAMPKWPNDVLVHGRKLSGVLIEAGLVVDALDYAVAGIGINVNTVCSELERDGMRA
VSLRGALETHHGTEQPQLPRAGVARAVLEGLEEAYELFRSGGGAAVVARWKQLAGITGSSIRLGRGDAVLTGKVRDVDDN
GWLLLEDESGTVHRLPAGDILDG
>Mature_342_residues
GLQLAFQEQGKGGAVRGAILEVLRKHDGNWVSGEELSRILGMSRAAVSKHMRLIRDAGYPVEAMTRRGYRLGGDADSLHP
AAVCHGLGTRLLGRGTVLHMESVPSTNMEARVLAERGAPEGSVVLADCQTAGRGRQGRTWLSPRGGVYMSVVLRPQCAPQ
QVPVLTLMTVVAVVGAVRGLTGLPAMPKWPNDVLVHGRKLSGVLIEAGLVVDALDYAVAGIGINVNTVCSELERDGMRAV
SLRGALETHHGTEQPQLPRAGVARAVLEGLEEAYELFRSGGGAAVVARWKQLAGITGSSIRLGRGDAVLTGKVRDVDDNG
WLLLEDESGTVHRLPAGDILDG

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=273, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1790408, Length=319, Percent_Identity=31.3479623824451, Blast_Score=124, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 36283; Mature: 36152

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLQLAFQEQGKGGAVRGAILEVLRKHDGNWVSGEELSRILGMSRAAVSKHMRLIRDAGY
CCCEEEECCCCCCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEAMTRRGYRLGGDADSLHPAAVCHGLGTRLLGRGTVLHMESVPSTNMEARVLAERGAP
CHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCC
EGSVVLADCQTAGRGRQGRTWLSPRGGVYMSVVLRPQCAPQQVPVLTLMTVVAVVGAVRG
CCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHC
LTGLPAMPKWPNDVLVHGRKLSGVLIEAGLVVDALDYAVAGIGINVNTVCSELERDGMRA
CCCCCCCCCCCCHHEEECCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
VSLRGALETHHGTEQPQLPRAGVARAVLEGLEEAYELFRSGGGAAVVARWKQLAGITGSS
EEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
IRLGRGDAVLTGKVRDVDDNGWLLLEDESGTVHRLPAGDILDG
EEECCCCEEEEEEEEEECCCCEEEEECCCCCEEECCCCCCCCC
>Mature Secondary Structure 
GLQLAFQEQGKGGAVRGAILEVLRKHDGNWVSGEELSRILGMSRAAVSKHMRLIRDAGY
CCEEEECCCCCCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEAMTRRGYRLGGDADSLHPAAVCHGLGTRLLGRGTVLHMESVPSTNMEARVLAERGAP
CHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCC
EGSVVLADCQTAGRGRQGRTWLSPRGGVYMSVVLRPQCAPQQVPVLTLMTVVAVVGAVRG
CCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHC
LTGLPAMPKWPNDVLVHGRKLSGVLIEAGLVVDALDYAVAGIGINVNTVCSELERDGMRA
CCCCCCCCCCCCHHEEECCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
VSLRGALETHHGTEQPQLPRAGVARAVLEGLEEAYELFRSGGGAAVVARWKQLAGITGSS
EEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
IRLGRGDAVLTGKVRDVDDNGWLLLEDESGTVHRLPAGDILDG
EEECCCCEEEEEEEEEECCCCEEEEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]